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Related papers: AnnoDPO: Protein Functional Annotation Learning wi…

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Accurately annotating and controlling protein function from sequence data remains a major challenge, particularly within homologous families where annotated sequences are scarce and structural variation is minimal. We present a two-stage…

Quantitative Methods · Quantitative Biology 2025-07-22 Lorenzo Rosset , Martin Weigt , Francesco Zamponi

Recent developments in Direct Preference Optimization (DPO) allow large language models (LLMs) to function as implicit ranking models by maximizing the margin between preferred and non-preferred responses. In practice, user feedback on such…

Machine Learning · Computer Science 2025-09-09 Junda Wu , Rohan Surana , Zhouhang Xie , Yiran Shen , Yu Xia , Tong Yu , Ryan A. Rossi , Prithviraj Ammanabrolu , Julian McAuley

Adapting Large Language Models (LLMs) for agent tasks is critical in developing language agents. Direct Preference Optimization (DPO) is a promising technique for this adaptation with the alleviation of compounding errors, offering a means…

Computation and Language · Computer Science 2025-02-25 Wentao Shi , Mengqi Yuan , Junkang Wu , Qifan Wang , Fuli Feng

Direct Preference Optimization (DPO) has gained attention as an efficient alternative to reinforcement learning from human feedback (RLHF) for aligning large language models (LLMs) with human preferences. Despite its advantages, DPO suffers…

Computation and Language · Computer Science 2025-02-21 Ruichen Shao , Bei Li , Gangao Liu , Yang Chen , Xiang Zhou , Jingang Wang , Xunliang Cai , Peng Li

Direct Preference Optimization (DPO) has emerged as a simple and effective approach for aligning large language models (LLMs) with human preferences, bypassing the need for a learned reward model. Despite its growing adoption, a fundamental…

Machine Learning · Computer Science 2025-11-10 Yu Pan , Zhongze Cai , Guanting Chen , Huaiyang Zhong , Chonghuan Wang

Fine-tuning pre-trained Large Language Models (LLMs) is essential to align them with human values and intentions. This process often utilizes methods like pairwise comparisons and KL divergence against a reference LLM, focusing on the…

Computation and Language · Computer Science 2024-09-02 Yongcheng Zeng , Guoqing Liu , Weiyu Ma , Ning Yang , Haifeng Zhang , Jun Wang

Direct Preference Optimization (DPO) has recently been applied as a post-training technique for text-to-video diffusion models. To obtain training data, annotators are asked to provide preferences between two videos generated from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Ziyi Wu , Anil Kag , Ivan Skorokhodov , Willi Menapace , Ashkan Mirzaei , Igor Gilitschenski , Sergey Tulyakov , Aliaksandr Siarohin

Multimodal protein features play a crucial role in protein function prediction. However, these features encompass a wide range of information, ranging from structural data and sequence features to protein attributes and interaction…

Machine Learning · Computer Science 2025-11-07 Xiaoling Luo , Peng Chen , Chengliang Liu , Xiaopeng Jin , Jie Wen , Yumeng Liu , Junsong Wang

Direct Preference Optimization (DPO) has recently emerged as a simple and effective alternative to reinforcement learning from human feedback (RLHF) for aligning large language models (LLMs) with user preferences. However, existing DPO…

Machine Learning · Computer Science 2025-10-10 Jason Bohne , Pawel Polak , David Rosenberg , Brian Bloniarz , Gary Kazantsev

The rapidly increasing capabilities of large language models (LLMs) raise an urgent need to align AI systems with diverse human preferences to simultaneously enhance their usefulness and safety, despite the often conflicting nature of these…

Machine Learning · Computer Science 2024-03-06 Zixuan Liu , Xiaolin Sun , Zizhan Zheng

Mathematical reasoning presents a significant challenge for Large Language Models (LLMs) as it requires ensuring the correctness of each reasoning step. Researchers have been strengthening the mathematical reasoning abilities of LLMs…

Machine Learning · Computer Science 2025-06-23 Yunze Lin

Large Language Models (LLMs) have demonstrated remarkable performance across various domains, motivating researchers to investigate their potential use in recommendation systems. However, directly applying LLMs to recommendation tasks has…

Information Retrieval · Computer Science 2024-06-21 Zhuoxi Bai , Ning Wu , Fengyu Cai , Xinyi Zhu , Yun Xiong

Fine-tuning is integral for aligning large language models (LLMs) with human preferences. Multiple-Reference Preference Optimization (MRPO) builds on Direct Preference Optimization (DPO) by fine-tuning LLMs on preference datasets while…

Machine Learning · Computer Science 2025-12-12 Skyler Wu , Aymen Echarghaoui

Direct Preference Optimization (DPO) is broadly utilized for aligning Large Language Models (LLMs) with human values because of its flexibility. Despite its effectiveness, it has been observed that the capability of DPO to generate…

Machine Learning · Computer Science 2025-05-20 Wenqiao Zhu , Ji Liu , Lulu Wang , Jun Wu , Yulun Zhang

Aligning large language models (LLMs) is a central objective of post-training, often achieved through reward modeling and reinforcement learning methods. Among these, direct preference optimization (DPO) has emerged as a widely adopted…

Computation and Language · Computer Science 2026-03-03 Aladin Djuhera , Farhan Ahmed , Swanand Ravindra Kadhe , Syed Zawad , Heiko Ludwig , Holger Boche

The alignment of large language models with human values presents a critical challenge, particularly when balancing conflicting objectives like helpfulness and harmlessness. Existing approaches, such as Reinforcement Learning from Human…

Computation and Language · Computer Science 2025-03-04 Yuxuan Liu

As Large Language Models (LLMs) demonstrate remarkable capabilities learned from vast corpora, concerns regarding data privacy and safety are receiving increasing attention. LLM unlearning, which aims to remove the influence of specific…

Machine Learning · Computer Science 2025-10-07 Kai Qin , Jiaqi Wu , Jianxiang He , Haoyuan Sun , Yifei Zhao , Bin Liang , Yongzhe Chang , Tiantian Zhang , Houde Liu

Reinforcement Learning from Human Feedback (RLHF) has been commonly used to align the behaviors of Large Language Models (LLMs) with human preferences. Recently, a popular alternative is Direct Policy Optimization (DPO), which replaces an…

Computation and Language · Computer Science 2024-06-03 Runsheng Yu , Yong Wang , Xiaoqi Jiao , Youzhi Zhang , James T. Kwok

Direct alignment methods typically train large language models (LLMs) by contrasting the likelihoods of preferred and dispreferred responses. While effective at capturing relative preferences, these methods are widely observed to suppress…

Computation and Language · Computer Science 2025-12-04 Kaiyang Guo , Yinchuan Li , Zhitang Chen

In the post-training of large language models (LLMs), Reinforcement Learning from Human Feedback (RLHF) is an effective approach to achieve generation aligned with human preferences. Direct Preference Optimization (DPO) allows for policy…

Machine Learning · Computer Science 2025-06-16 Motoki Omura , Yasuhiro Fujita , Toshiki Kataoka
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