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Direct alignment algorithms such as Direct Preference Optimization (DPO) fine-tune models based on preference data, using only supervised learning instead of two-stage reinforcement learning with human feedback (RLHF). We show that DPO…

Machine Learning · Computer Science 2025-10-24 Aditya Gopalan , Sayak Ray Chowdhury , Debangshu Banerjee

Large Vision-Language Models (LVLMs) or multimodal large language models represent a significant advancement in artificial intelligence, enabling systems to understand and generate content across both visual and textual modalities. While…

Machine Learning · Computer Science 2025-09-09 Thanh Thi Nguyen , Campbell Wilson , Janis Dalins

Direct Preference Optimisation (DPO) has emerged as a powerful method for aligning Large Language Models (LLMs) with human preferences, offering a stable and efficient alternative to approaches that use Reinforcement learning via Human…

Artificial Intelligence · Computer Science 2025-05-06 Sarvesh Shashidhar , Ritik , Nachiketa Patil , Suraj Racha , Ganesh Ramakrishnan

Reinforcement Learning from Human Feedback (RLHF) has emerged as a pivotal tool for aligning large language models (LLMs) with human preferences. Direct Preference Optimization (DPO), one of the most popular approaches, formulates RLHF as a…

Machine Learning · Computer Science 2024-10-10 Jiafan He , Huizhuo Yuan , Quanquan Gu

Direct Preference Optimization (DPO) aligns Large Language Models with human preferences without the need for a separate reward model. However, DPO treats all tokens in responses equally, neglecting the differing importance of individual…

Computation and Language · Computer Science 2026-05-27 Chengyu Huang , Zhuohang Li , Sheng-Yen Chou , Claire Cardie

Direct Preference Optimization (DPO) has emerged as a predominant alignment method for diffusion models, facilitating off-policy training without explicit reward modeling. However, its reliance on large-scale, high-quality human preference…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Khiem Pham , Quang Nguyen , Tung Nguyen , Jingsen Zhu , Michele Santacatterina , Dimitris Metaxas , Ramin Zabih

While large-scale unsupervised language models (LMs) learn broad world knowledge and some reasoning skills, achieving precise control of their behavior is difficult due to the completely unsupervised nature of their training. Existing…

Machine Learning · Computer Science 2024-07-31 Rafael Rafailov , Archit Sharma , Eric Mitchell , Stefano Ermon , Christopher D. Manning , Chelsea Finn

In this paper, we introduce \emph{refined Direct Preference Optimization} (rDPO), a method for improving the behavioral alignment of Large Language Models (LLMs) without the need for human-annotated data. The method involves creating…

Computation and Language · Computer Science 2024-02-14 Víctor Gallego

Designing proteins with desired functions or properties represents a core goal in synthetic biology and drug discovery. Recent advances in protein language models (PLMs) have enabled the generation of highly designable protein sequences,…

Machine Learning · Computer Science 2026-05-12 Yulin Zhang , He Cao , Zihao Jiang , Chenyi Zi , Zhipeng Zhou , Zijing Liu , Yu Li , Jia Li , Ziqi Gao

Human preference alignment is essential to improve the interaction quality of large language models (LLMs). Existing alignment methods depend on manually annotated preference data to guide the LLM optimization directions. However,…

Computation and Language · Computer Science 2024-06-04 Pengyu Cheng , Yifan Yang , Jian Li , Yong Dai , Tianhao Hu , Peixin Cao , Nan Du , Xiaolong Li

With the rapid development and widespread application of Large Language Models (LLMs), their potential safety risks have attracted widespread attention. Reinforcement Learning from Human Feedback (RLHF) has been adopted to enhance the…

Artificial Intelligence · Computer Science 2026-03-25 Shiji Zhao , Mengyang Wang , Shukun Xiong , Fangzhou Chen , Qihui Zhu , Shouwei Ruan , Yisong Xiao , Ranjie Duan , Xun Chen , XingXing Wei

For aligning large language models (LLMs), prior work has leveraged reinforcement learning via human feedback (RLHF) or variations of direct preference optimization (DPO). While DPO offers a simpler framework based on maximum likelihood…

Artificial Intelligence · Computer Science 2025-05-27 Anirudhan Badrinath , Prabhat Agarwal , Jiajing Xu

Large Vision-Language Models (LVLMs) hold immense potential for complex multimodal instruction following, yet their development is often hindered by the high cost and inconsistency of human annotation required for effective fine-tuning and…

Computation and Language · Computer Science 2025-08-19 Ruirui Gao , Emily Johnson , Bowen Tan , Yanfei Qian

Direct Preference Optimization (DPO) has emerged as a de-facto approach for aligning language models with human preferences. Recent work has shown DPO's effectiveness relies on training data quality. In particular, clear quality differences…

Machine Learning · Computer Science 2025-01-28 Nirav Diwan , Tolga Ergen , Dongsub Shim , Honglak Lee

Direct Preference Optimization (DPO) is an effective framework for aligning large language models with human preferences, but it struggles with complex reasoning tasks. DPO optimizes for the likelihood of generating preferred over…

Artificial Intelligence · Computer Science 2026-04-23 Darsh Kachroo , Adriana Caraeni , Arjun Prasaath Anbazhagan , Brennan Lagasse , Kevin Zhu

Direct Preference Optimization (DPO) have emerged as a popular method for aligning Large Language Models (LLMs) with human preferences. While DPO effectively preserves the relative ordering between chosen and rejected responses through…

Computation and Language · Computer Science 2025-06-05 Lin Sun , Chuang Liu , Peng Liu , Bingyang Li , Weijia Lu , Ning Wu

We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Multiple design objectives are encoded in the language model…

Biological Physics · Physics 2024-03-08 Pouria Mistani , Venkatesh Mysore

Fairness in Continual Learning for Large Multimodal Models (LMMs) is an emerging yet underexplored challenge, particularly in the presence of imbalanced data distributions that can lead to biased model updates and suboptimal performance…

Machine Learning · Computer Science 2026-03-31 Thanh-Dat Truong , Huu-Thien Tran , Jackson Cothren , Bhiksha Raj , Khoa Luu

Aligning large language models (LLMs) to human preferences is a crucial step in building helpful and safe AI tools, which usually involve training on supervised datasets. Popular algorithms such as Direct Preference Optimization (DPO) rely…

Computation and Language · Computer Science 2025-06-05 Honggen Zhang , Xufeng Zhao , Igor Molybog , June Zhang

Reinforcement learning from human feedback (RLHF) plays a crucial role in aligning language models with human preferences. While the significance of dataset quality is generally recognized, explicit investigations into its impact within the…

Machine Learning · Computer Science 2024-12-04 Tetsuro Morimura , Mitsuki Sakamoto , Yuu Jinnai , Kenshi Abe , Kaito Ariu