Related papers: AnnoDPO: Protein Functional Annotation Learning wi…

Inverse folding models play an important role in structure-based design by predicting amino acid sequences that fold into desired reference structures. Models like ProteinMPNN, a message-passing encoder-decoder model, are trained to…

Paraphrasing re-expresses meaning to enhance applications like text simplification, machine translation, and question-answering. Specific paraphrase types facilitate accurate semantic analysis and robust language models. However, existing…

Direct Preference Optimization (DPO) has emerged as a promising approach for aligning large language models with human preferences. While prior work mainly extends DPO from the aspect of the objective function, we instead improve DPO from…

Protein function prediction is a crucial task in bioinformatics, with significant implications for understanding biological processes and disease mechanisms. While the relationship between sequence and function has been extensively…

Offline preference optimization methods are efficient for large language models (LLMs) alignment. Direct Preference optimization (DPO)-like learning, one of the most popular approaches, stands out for its efficiency in reward modeling.…

Resource-efficient training optimization techniques are becoming increasingly important as the size of large language models (LLMs) continues to grow. In particular, batch packing is commonly used in pre-training and supervised fine-tuning…

Direct Preference Optimization (DPO) is a widely adopted offline algorithm for preference-based reinforcement learning from human feedback (RLHF), designed to improve training simplicity and stability by redefining reward functions.…

As the era of large language models (LLMs) unfolds, Preference Optimization (PO) methods have become a central approach to aligning LLMs with human preferences and improving performance. We propose Maximum a Posteriori Preference…

Preference learning is a key technology for aligning language models with human values. Reinforcement Learning from Human Feedback (RLHF) is a model-based algorithm to optimize preference learning, which first fits a reward model for…

Learning from preference feedback has emerged as an essential step for improving the generation quality and performance of modern language models (LMs). Despite its widespread use, the way preference-based learning is applied varies wildly,…

Aligning large language models with human preferences is essential for improving interaction quality and safety by ensuring outputs better reflect human values. A promising strategy involves Reinforcement Learning from Human Feedback…

Public repositories for genome and proteome annotations, such as the Gene Ontology (GO), rarely stores negative annotations, i.e. proteins not possessing a given function. This leaves undefined or ill defined the set of negative examples,…

Direct Preference Optimization (DPO) has emerged as a more computationally efficient alternative to Reinforcement Learning from Human Feedback (RLHF) with Proximal Policy Optimization (PPO), eliminating the need for reward models and online…

Large Language Models (LLMs) can become outdated over time as they may lack updated world knowledge, leading to factual knowledge errors and gaps. Knowledge Editing (KE) aims to overcome this challenge using weight updates that do not…

Effective training of language models (LMs) for mathematical reasoning tasks demands high-quality supervised fine-tuning data. Besides obtaining annotations from human experts, a common alternative is sampling from larger and more powerful…

We study the problem of aligning large language models (LLMs) with human preference data. Contrastive preference optimization has shown promising results in aligning LLMs with available preference data by optimizing the implicit reward…

Preference alignment in Large Language Models (LLMs) has significantly improved their ability to adhere to human instructions and intentions. However, existing direct alignment algorithms primarily focus on relative preferences and often…

Radiography Report Generation (RRG) has gained significant attention in medical image analysis as a promising tool for alleviating the growing workload of radiologists. However, despite numerous advancements, existing methods have yet to…

Preference alignment is an essential step in adapting large language models (LLMs) to human values, but existing approaches typically depend on costly human annotations or large-scale API-based models. We explore whether a weak LLM can…

We present DuPO, a dual learning-based preference optimization framework that generates annotation-free feedback via a generalized duality. DuPO addresses two key limitations: Reinforcement Learning with Verifiable Rewards (RLVR)'s reliance…