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Objective: This paper introduces a patient simulator for scalable, automated evaluation of healthcare conversational agents, generating realistic, controllable interactions that systematically vary across medical, linguistic, and behavioral…

Background: Simulated patient systems are important in medical education and research, providing safe, integrative training environments and supporting clinical decision making. Advances in artificial intelligence (AI), especially large…

Doctor-patient consultations require multi-turn, context-aware communication tailored to diverse patient personas. Training or evaluating doctor LLMs in such settings requires realistic patient interaction systems. However, existing…

Artificial Intelligence · Computer Science 2025-10-30 Daeun Kyung , Hyunseung Chung , Seongsu Bae , Jiho Kim , Jae Ho Sohn , Taerim Kim , Soo Kyung Kim , Edward Choi

Online health resources and large language models (LLMs) are increasingly used as a first point of contact for medical decision-making, yet their reliability in healthcare remains limited by low accuracy, lack of transparency, and…

Artificial Intelligence · Computer Science 2026-04-22 Yujia Liu , Sophia Yu , Hongyue Jin , Jessica Wen , Alexander Qian , Terrence Lee , Mattheus Ramsis , Gi Won Choi , Lianhui Qin , Xin Liu , Edward J. Wang

Training mental health clinicians to conduct standardized clinical assessments is challenging due to a lack of scalable, realistic practice opportunities, which can impact data quality in clinical trials. To address this gap, we introduce a…

Human-Computer Interaction · Computer Science 2025-12-30 Veronica Bossio Botero , Vijay Yadav , Jacob Ouyang , Anzar Abbas , Michelle Worthington

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

Computation and Language · Computer Science 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

Artificial intelligence has significantly advanced healthcare, particularly through large language models (LLMs) that excel in medical question answering benchmarks. However, their real-world clinical application remains limited due to the…

Computation and Language · Computer Science 2024-07-01 Zhihao Fan , Jialong Tang , Wei Chen , Siyuan Wang , Zhongyu Wei , Jun Xi , Fei Huang , Jingren Zhou

Testing conversational AI systems at scale across diverse domains necessitates realistic and diverse user interactions capturing a wide array of behavioral patterns. We present a novel multi-agent framework for realistic, explainable human…

Human-Computer Interaction · Computer Science 2026-01-23 Hareeshwar Karthikeyan

The recent rapid development of large language models (LLMs) has sparked a new wave of technological revolution in medical artificial intelligence (AI). While LLMs are designed to understand and generate text like a human, autonomous agents…

Artificial Intelligence · Computer Science 2025-01-20 Junkai Li , Yunghwei Lai , Weitao Li , Jingyi Ren , Meng Zhang , Xinhui Kang , Siyu Wang , Peng Li , Ya-Qin Zhang , Weizhi Ma , Yang Liu

Background: Globally we face a projected shortage of 11 million healthcare practitioners by 2030, and administrative burden consumes 50% of clinical time. Artificial intelligence (AI) has the potential to help alleviate these problems.…

Human-Computer Interaction · Computer Science 2025-08-01 Hashim Hayat , Maksim Kudrautsau , Evgeniy Makarov , Vlad Melnichenko , Tim Tsykunou , Piotr Varaksin , Matt Pavelle , Adam Z. Oskowitz

The shortage of doctors is creating a critical squeeze in access to medical expertise. While conversational Artificial Intelligence (AI) holds promise in addressing this problem, its safe deployment in patient-facing roles remains largely…

Artificial Intelligence · Computer Science 2025-04-11 Antoine Lizée , Pierre-Auguste Beaucoté , James Whitbeck , Marion Doumeingts , Anaël Beaugnon , Isabelle Feldhaus

Problem: Effective patient-centered communication is a core competency for physicians. However, both seasoned providers and medical trainees report decreased confidence in leading conversations on sensitive topics such as goals of care or…

Human-Computer Interaction · Computer Science 2024-05-31 Simon N. Chu , Alex J. Goodell

Medical conversational AI (AI) plays a pivotal role in the development of safer and more effective medical dialogue systems. However, existing benchmarks and evaluation frameworks for assessing the information-gathering and diagnostic…

Computation and Language · Computer Science 2026-01-08 Lecheng Gong , Weimin Fang , Ting Yang , Dongjie Tao , Chunxiao Guo , Peng Wei , Bo Xie , Jinqun Guan , Zixiao Chen , Fang Shi , Jinjie Gu , Junwei Liu

Language models excel at diagnostic assessments on curated medical case-studies and vignettes, performing on par with, or better than, clinical professionals. However, existing studies focus on complex scenarios with rich context making it…

Banks receive millions of reports of fraud, scams, and disputed transactions every year, making it challenging to accurately direct customers to the appropriate specialist teams for assistance. The existing manual process driven by humans…

Patient safety training is essential for preparing healthcare professionals to identify, investigate, and prevent adverse events. However, conventional simulation-based approaches often require substantial faculty time, physical resources,…

Human-Computer Interaction · Computer Science 2026-03-20 Yuqi Hu , Qiwen Xiong , Zhenzhen Qin , Brandon Watanabe , Yujing Wang , Mirjana Prpa , Ilmi Yoon

Embodied agents designed to assist users with tasks must engage in natural language interactions, interpret instructions, execute actions, and communicate effectively to resolve issues. However, collecting large-scale, diverse datasets of…

Computation and Language · Computer Science 2024-11-01 Daniel Philipov , Vardhan Dongre , Gokhan Tur , Dilek Hakkani-Tür

Simulations constitute a fundamental component of medical and nursing education and traditionally employ standardized patients (SP) and high-fidelity manikins to develop clinical reasoning and communication skills. However, these methods…

Human-Computer Interaction · Computer Science 2025-10-23 Akilan Amithasagaran , Sagnik Dakshit , Bhavani Suryadevara , Lindsey Stockton

The premise of this working paper is based around agent-based simulation models and how to go about creating them from given incomplete information. Agent-based simulations are stochastic simulations that revolve around groups of agents…

Multiagent Systems · Computer Science 2019-02-06 Daniel Stroud , Christian Wagner , Peer-Olaf Siebers

Healthcare professionals need effective ways to use, understand, and validate AI-driven clinical decision support systems. Existing systems face two key limitations: complex visualizations and a lack of grounding in scientific evidence. We…

Human-Computer Interaction · Computer Science 2025-07-08 Reza Samimi , Aditya Bhattacharya , Lucija Gosak , Gregor Stiglic , Katrien Verbert
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