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Quantifying uncertainty in clinical predictions is critical for high-stakes diagnosis tasks. Conformal prediction offers a principled approach by providing prediction sets with theoretical coverage guarantees. However, in practice, patient…

Machine Learning · Computer Science 2026-05-01 Arjun Chatterjee , Sayeed Sajjad Razin , John Wu , Siddhartha Laghuvarapu , Jathurshan Pradeepkumar , Jimeng Sun

We propose a conformal prediction method for constructing tight simultaneous prediction intervals for multiple, potentially related, numerical outputs given a single input. This method can be combined with any multi-target regression model…

Methodology · Statistics 2025-12-18 Yunjie Fan , Matteo Sesia

The process of manually searching for relevant instances in, and extracting information from, clinical databases underpin a multitude of clinical tasks. Such tasks include disease diagnosis, clinical trial recruitment, and continuing…

Signal Processing · Electrical Eng. & Systems 2021-10-05 Dani Kiyasseh , Tingting Zhu , David A. Clifton

Cardiovascular disease (CVD) is a common and strong threat to human beings, featuring high prevalence, disability and mortality. The amount of coronary artery calcification (CAC) is an effective factor for CVD risk evaluation.…

Image and Video Processing · Electrical Eng. & Systems 2019-07-29 Jiechao Ma , Rongguo Zhang

Methods to quantify uncertainty in predictions from arbitrary models are in demand in high-stakes domains like medicine and finance. Conformal prediction has emerged as a popular method for producing a set of predictions with specified…

Machine Learning · Computer Science 2025-03-19 Jessica Hullman , Yifan Wu , Dawei Xie , Ziyang Guo , Andrew Gelman

Coronary artery calcium (CAC) burden quantified in low-dose chest CT is a predictor of cardiovascular events. We propose an automatic method for CAC quantification, circumventing intermediate segmentation of CAC. The method determines a…

Computer Vision and Pattern Recognition · Computer Science 2017-12-11 Bob D. de Vos , Nikolas Lessmann , Pim A. de Jong , Max A. Viergever , Ivana Isgum

Despite recent progress in predicting biomarker trajectories from real clinical data, uncertainty in the predictions poses high-stakes risks (e.g., misdiagnosis) that limit their clinical deployment. To enable safe and reliable use of such…

Machine Learning · Statistics 2025-11-19 Vasiliki Tassopoulou , Charis Stamouli , Haochang Shou , George J. Pappas , Christos Davatzikos

Before deploying outputs from foundation models in high-stakes tasks, it is imperative to ensure that they align with human values. For instance, in radiology report generation, reports generated by a vision-language model must align with…

Machine Learning · Statistics 2024-11-06 Yu Gui , Ying Jin , Zhimei Ren

Coronary Heart Disease affects millions of people worldwide and is a well-studied area of healthcare. There are many viable and accurate methods for the diagnosis and prediction of heart disease, but they have limiting points such as…

Artificial Intelligence · Computer Science 2024-09-24 Jamal Al-Karaki , Philip Ilono , Sanchit Baweja , Jalal Naghiyev , Raja Singh Yadav , Muhammad Al-Zafar Khan

We propose a multi-scale extension of conformal prediction, an approach that constructs prediction sets with finite-sample coverage guarantees under minimal statistical assumptions. Classic conformal prediction relies on a single notion of…

Statistics Theory · Mathematics 2025-02-11 Ali Baheri , Marzieh Amiri Shahbazi

Machine learning classification tasks often benefit from predicting a set of possible labels with confidence scores to capture uncertainty. However, existing methods struggle with the high-dimensional nature of the data and the lack of…

Machine Learning · Computer Science 2024-07-08 Rui Luo , Zhixin Zhou

In demographic literature, forecast uncertainty is often quantified with a statistical model. This model-based approach may potentially suffer from drawbacks, namely model misspecification, selection effect, and lack of finite-sample…

Applications · Statistics 2026-05-29 Han Lin Shang

Conformal prediction is a framework for uncertainty quantification that constructs prediction sets for previously unseen data, guaranteeing coverage of the true label with a specified probability. However, the efficiency of these prediction…

Machine Learning · Computer Science 2026-01-06 Erfan Hajihashemi , Yanning Shen

While clustering is ubiquitously used across science and industry, uncertainty in cluster assignments is rarely quantified with rigorous guarantees. We propose a novel conformal inference framework for clustering that returns confidence…

Methodology · Statistics 2026-04-13 YoonHaeng Hur , Anirban Nath , Genevera Allen

The analysis of plaque deposits in the coronary vasculature is an important topic in current clinical research. From a technical side mostly new algorithms for different sub tasks - e.g. centerline extraction or vessel/plaque segmentation -…

Computer Vision and Pattern Recognition · Computer Science 2021-01-12 Felix Denzinger , Michael Wels , Christian Hopfgartner , Jing Lu , Max Schöbinger , Andreas Maier , Michael Sühling

Predictive models make mistakes. Hence, there is a need to quantify the uncertainty associated with their predictions. Conformal inference has emerged as a powerful tool to create statistically valid prediction regions around point…

Machine Learning · Statistics 2024-02-14 Luben M. C. Cabezas , Mateus P. Otto , Rafael Izbicki , Rafael B. Stern

Depth measures have gained popularity in the statistical literature for defining level sets in complex data structures like multivariate data, functional data, and graphs. Despite their versatility, integrating depth measures into…

Background: Extensive clinical evidence suggests that a preventive screening of coronary heart disease (CHD) at an earlier stage can greatly reduce the mortality rate. We use 64 two-dimensional speckle tracking echocardiography (2D-STE)…

Machine Learning · Statistics 2021-05-21 Jingyi Zhang , Huolan Zhu , Yongkai Chen , Chenguang Yang , Huimin Cheng , Yi Li , Wenxuan Zhong , Fang Wang

Conformal Prediction is a framework that produces prediction intervals based on the output from a machine learning algorithm. In this paper we explore the case when training data is made up of multiple parts available in different sources…

Machine Learning · Statistics 2019-08-16 Ola Spjuth , Robin Carrión Brännström , Lars Carlsson , Niharika Gauraha

Current instance segmentation models achieve high performance on average predictions, but lack principled uncertainty quantification: their outputs are not calibrated, and there is no guarantee that a predicted mask is close to the ground…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Kerri Lu , Dan M. Kluger , Stephen Bates , Sherrie Wang