Related papers: Protein Inverse Folding From Structure Feedback

Modern alignment pipelines are increasingly replacing expensive human preference labels with evaluations from large language models (LLM-as-Judge). However, AI labels can be systematically biased compared to high-quality human feedback…

Direct Preference Optimization (DPO) has been proposed as a promising alternative to Proximal Policy Optimization (PPO) based Reinforcement Learning with Human Feedback (RLHF). However, empirical evaluations consistently reveal suboptimal…

Aligning large language models with human preferences is crucial for their safe deployment. While Direct Preference Optimization (DPO) offers an efficient alternative to reinforcement learning from human feedback, traditional DPO methods…

Preference optimization (PO) is indispensable for large language models (LLMs), with methods such as direct preference optimization (DPO) and proximal policy optimization (PPO) achieving great success. A common belief is that DPO is…

Direct preference optimization (DPO) has emerged as a promising approach for aligning large language models (LLMs) with human preferences. However, the widespread reliance on the response-level Bradley-Terry (BT) model may limit its full…

Direct preference optimization (\texttt{DPO}) has emerged as a promising approach for solving the alignment problem in AI. In this paper, we make two counter-intuitive observations about \texttt{DPO}. First, we show that \texttt{DPO} loss…

Generative AI can now synthesize strikingly realistic images from text, yet output quality remains highly sensitive to how prompts are phrased. Direct Preference Optimization (DPO) offers a lightweight, off-policy alternative to RL for…

Direct Preference Optimization (DPO) has recently been applied as a post-training technique for text-to-video diffusion models. To obtain training data, annotators are asked to provide preferences between two videos generated from…

Protein inverse folding, the design of an amino acid sequence based on a target protein structure, is a fundamental problem of computational protein engineering. Existing methods either generate sequences without leveraging external…

Direct preference optimization (DPO), a widely adopted offline preference optimization algorithm, aims to align large language models (LLMs) with human-desired behaviors using pairwise preference data. However, the generation of the winning…

Direct Preference Optimization (DPO) has been proposed as an effective and efficient alternative to reinforcement learning from human feedback (RLHF). However, neither RLHF nor DPO take into account the fact that learning certain…

Large Language Models (LLMs) have become pivotal in advancing natural language processing, yet their potential to perpetuate biases poses significant concerns. This paper introduces a new framework employing Direct Preference Optimization…

Recent advancements in diffusion models (DMs) have been propelled by alignment methods that post-train models to better conform to human preferences. However, these approaches typically require computation-intensive training of a base model…

Protein folding is the intricate process by which a linear sequence of amino acids self-assembles into a unique three-dimensional structure. Protein folding kinetics is the study of pathways and time-dependent mechanisms a protein undergoes…

Aligning large language models (LLMs) with human preferences has gained significant attention, with Proximal Policy Optimization (PPO) as a standard yet computationally expensive method and Direct Preference Optimization (DPO) as a more…

Direct Preference Optimization (DPO) has gained significant attention for its simplicity and computational efficiency in aligning large language models (LLMs). Recent advancements have extended DPO to multimodal scenarios, achieving strong…

The effectiveness of Direct Preference Optimization (DPO) depends on preference data that reflect the quality differences that matter in multimodal tasks. Existing pipelines often rely on off-policy perturbations or coarse outcome-based…

We apply a new approach to the reverse protein folding problem. Our method uses a minimization function in the design process which is different from the energy function used for folding. For a lattice model, we show that this new approach…

Direct preference optimization (DPO) methods have shown strong potential in aligning text-to-image diffusion models with human preferences by training on paired comparisons. These methods improve training stability by avoiding the REINFORCE…

Direct Preference Optimization (DPO) optimizes language models to align with human preferences. Utilizing on-policy samples, generated directly by the policy model, typically results in better performance due to its distribution consistency…