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Related papers: Processing-in-memory for genomics workloads

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Computing on encrypted data is a promising approach to reduce data security and privacy risks, with homomorphic encryption serving as a facilitator in achieving this goal. In this work, we accelerate homomorphic operations using the…

Cryptography and Security · Computer Science 2023-10-04 Harshita Gupta , Mayank Kabra , Juan Gómez-Luna , Konstantinos Kanellopoulos , Onur Mutlu

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level.…

The performance gap between memory and processor has grown rapidly. Consequently, the energy and wall-clock time costs associated with moving data between the CPU and main memory predominate the overall computational cost. The…

Hardware Architecture · Computer Science 2024-03-01 Qingcai Jiang , Shaojie Tan , Junshi Chen , Hong An

Neural networks (NNs) are growing in importance and complexity. A neural network's performance (and energy efficiency) can be bound either by computation or memory resources. The processing-in-memory (PIM) paradigm, where computation is…

Hardware Architecture · Computer Science 2023-03-28 Geraldo F. Oliveira , Juan Gómez-Luna , Saugata Ghose , Amirali Boroumand , Onur Mutlu

The utilization of large-scale neural networks on Processing-In-Memory (PIM) accelerators encounters challenges due to constrained on-chip memory capacity. To tackle this issue, current works explore model compression algorithms to reduce…

Hardware Architecture · Computer Science 2024-04-18 Chenyu Wang , Zhen Dong , Daquan Zhou , Zhenhua Zhu , Yu Wang , Jiashi Feng , Kurt Keutzer

Modern computing systems are limited in performance by the memory bandwidth available to processors, a problem known as the memory wall. Processing-in-Memory (PIM) promises to substantially improve this problem by moving processing closer…

Cryptography and Security · Computer Science 2025-04-24 Sahar Ghoflsaz Ghinani , Jingyao Zhang , Elaheh Sadredini

Edge computing is a popular target for accelerating machine learning algorithms supporting mobile devices without requiring the communication latencies to handle them in the cloud. Edge deployments of machine learning primarily consider…

Hardware Architecture · Computer Science 2024-10-28 Sébastien Ollivier , Sheng Li , Yue Tang , Chayanika Chaudhuri , Peipei Zhou , Xulong Tang , Jingtong Hu , Alex K. Jones

Training machine learning (ML) algorithms is a computationally intensive process, which is frequently memory-bound due to repeatedly accessing large training datasets. As a result, processor-centric systems (e.g., CPU, GPU) suffer from…

Hardware Architecture · Computer Science 2023-09-07 Juan Gómez-Luna , Yuxin Guo , Sylvan Brocard , Julien Legriel , Remy Cimadomo , Geraldo F. Oliveira , Gagandeep Singh , Onur Mutlu

Processing in Memory (PIM) and similar terms such as Compute In Memory (CIM), Logic in Memory (LIM), In Memory Computing (IMC), and Near Memory Computing (NMC) have gained attention recently as a potentially ``revolutionary new'' technique.…

Hardware Architecture · Computer Science 2026-01-15 Peter M. Kogge

Recent DNA pre-alignment filter designs employ DRAM for storing the reference genome and its associated meta-data. However, DRAM incurs increasingly high energy consumption background and refresh energy as devices scale. To overcome this…

Emerging Technologies · Computer Science 2022-12-27 Fazal Hameed , Asif Ali Khan , Sebastien Ollivier , Alex K. Jones , Jeronimo Castrillon

Computing-in-memory (CIM) has attracted significant attentions in recent years due to its massive parallelism and low power consumption. However, current CIM designs suffer from large area overhead of small CIM macros and bad programmablity…

Hardware Architecture · Computer Science 2022-05-04 Shu-Hung Kuo , Tian-Sheuan Chang

High-performance computing systems are moving towards 2.5D and 3D memory hierarchies, based on High Bandwidth Memory (HBM) and Hybrid Memory Cube (HMC) to mitigate the main memory bottlenecks. This trend is also creating new opportunities…

Hardware Architecture · Computer Science 2017-09-26 Erfan Azarkhish , Davide Rossi , Igor Loi , Luca Benini

Demand for data-intensive workloads and confidential computing are the prominent research directions shaping the future of cloud computing. Computer architectures are evolving to accommodate the computing of large data better. Protecting…

Cryptography and Security · Computer Science 2023-04-11 Kha Dinh Duy , Hojoon Lee

Genome analysis fundamentally starts with a process known as read mapping, where sequenced fragments of an organism's genome are compared against a reference genome. Read mapping is currently a major bottleneck in the entire genome analysis…

Hardware Architecture · Computer Science 2020-10-29 Mohammed Alser , Zülal Bingöl , Damla Senol Cali , Jeremie Kim , Saugata Ghose , Can Alkan , Onur Mutlu

Bit-serial Processing-In-Memory (PIM) is an attractive paradigm for accelerator architectures, for parallel workloads such as Deep Learning (DL), because of its capability to achieve massive data parallelism at a low area overhead and…

Hardware Architecture · Computer Science 2023-11-21 Aman Arora , Jian Weng , Siyuan Ma , Tony Nowatzki , Lizy K. John

Genome sequence alignment is the core of many biological applications. The advancement of sequencing technologies produces a tremendous amount of data, making sequence alignment a critical bottleneck in bioinformatics analysis. The existing…

Hardware Architecture · Computer Science 2023-01-26 Weihong Xu , Saransh Gupta , Niema Moshiri , Tajana Rosing

Modern Machine Learning (ML) training on large-scale datasets is a very time-consuming workload. It relies on the optimization algorithm Stochastic Gradient Descent (SGD) due to its effectiveness, simplicity, and generalization performance.…

Hardware Architecture · Computer Science 2024-09-30 Steve Rhyner , Haocong Luo , Juan Gómez-Luna , Mohammad Sadrosadati , Jiawei Jiang , Ataberk Olgun , Harshita Gupta , Ce Zhang , Onur Mutlu

Chiplet-based integration enables large-scale systems that combine diverse technologies, enabling higher yield, lower costs, and scalability, making them well-suited to AI workloads. Processing-in-Memory (PIM) has emerged as a promising…

Hardware Architecture · Computer Science 2025-08-15 Alish Kanani , Lukas Pfromm , Harsh Sharma , Janardhan Rao Doppa , Partha Pratim Pande , Umit Y. Ogras

Processing-in-memory (PIM) architectures allow software to explicitly initiate computation in the memory. This effectively makes PIM operations a new class of memory operations, alongside standard memory operations (e.g., load, store). For…

Hardware Architecture · Computer Science 2022-12-08 Ben Perach , Ronny Ronnen , Shahar Kvatinsky

Fully Homomorphic Encryption (FHE) is a technique that allows arbitrary computations to be performed on encrypted data without the need for decryption, making it ideal for securing many emerging applications. However, FHE computation is…