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Related papers: Processing-in-memory for genomics workloads

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Processing-in-Memory (PIM) architectures offer promising solutions for efficiently handling AI applications in energy-constrained edge environments. While traditional PIM designs enhance performance and energy efficiency by reducing data…

Hardware Architecture · Computer Science 2025-12-09 Sangmin Jeon , Kangju Lee , Kyeongwon Lee , Woojoo Lee

Although deep learning-based personalized recommendation systems provide qualified recommendations, they strain data center resources. The main bottleneck is the embedding layer, which is highly memory-intensive due to its sparse, irregular…

Hardware Architecture · Computer Science 2025-11-26 Youngsuk Kim , Junghwan Lim , Hyuk-Jae Lee , Chae Eun Rhee

Processing-in-memory (PIM) architectures bring computation closer to data, reducing the processor-memory transfer bottleneck in traditional processor-centric designs. Novel hardware solutions, such as UPMEM's in-memory processing…

Emerging Technologies · Computer Science 2026-04-10 Peterson Yuhala , Mpoki Mwaisela , Pascal Felber , Valerio Schiavoni

The deployment of large language models (LLMs) presents significant challenges due to their enormous memory footprints, low arithmetic intensity, and stringent latency requirements, particularly during the autoregressive decoding stage.…

Hardware Architecture · Computer Science 2025-11-03 Cenlin Duan , Jianlei Yang , Rubing Yang , Yikun Wang , Yiou Wang , Lingkun Long , Yingjie Qi , Xiaolin He , Ao Zhou , Xueyan Wang , Weisheng Zhao

Processing-in-memory (PIM) architectures are emerging to reduce data movement in data-intensive applications. These architectures seek to exploit the same physical devices for both information storage and logic, thereby dwarfing the…

Hardware Architecture · Computer Science 2023-05-09 Orian Leitersdorf , Ronny Ronen , Shahar Kvatinsky

Processing large-scale graph datasets is computationally intensive and time-consuming. Processor-centric CPU and GPU architectures, commonly used for graph applications, often face bottlenecks caused by extensive data movement between the…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-11 Marzieh Barkhordar , Alireza Tabatabaeian , Mohammad Sadrosadati , Christina Giannoula , Juan Gomez Luna , Izzat El Hajj , Onur Mutlu , Alaa R. Alameldeen

Processing-in-memory (PIM) promises to alleviate the data movement bottleneck in modern computing systems. However, current real-world PIM systems have the inherent disadvantage that their hardware is more constrained than in conventional…

Mathematical Software · Computer Science 2023-09-07 Maurus Item , Juan Gómez-Luna , Yuxin Guo , Geraldo F. Oliveira , Mohammad Sadrosadati , Onur Mutlu

The widespread integration of embedded systems across various industries has facilitated seamless connectivity among devices and bolstered computational capabilities. Despite their extensive applications, embedded systems encounter…

Cryptography and Security · Computer Science 2024-04-16 Sreenitha Kasarapu , Sathwika Bavikadi , Sai Manoj Pudukotai Dinakarrao

Processing-in-Memory (PIM) enhances memory with computational capabilities, potentially solving energy and latency issues associated with data transfer between memory and processors. However, managing concurrent computation and data flow…

Hardware Architecture · Computer Science 2025-05-09 Ahmed Mamdouh , Haoran Geng , Michael Niemier , Xiaobo Sharon Hu , Dayane Reis

Massive exploitation of next-generation sequencing technologies requires dealing with both: huge amounts of data and complex bioinformatics pipelines. Computing architectures have evolved to deal with these problems, enabling approaches…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-07-07 Aaron Call , Jordà Polo , David Carrera , Francesc Guim , Sujoy Sen

Processing-in-memory (PIM) has emerged as a promising solution for accelerating memory-intensive workloads as they provide high memory bandwidth to the processing units. This approach has drawn attention not only from the academic community…

Hardware Architecture · Computer Science 2024-09-11 Dongjae Lee , Bongjoon Hyun , Taehun Kim , Minsoo Rhu

Training machine learning algorithms is a computationally intensive process, which is frequently memory-bound due to repeatedly accessing large training datasets. As a result, processor-centric systems (e.g., CPU, GPU) suffer from costly…

Hardware Architecture · Computer Science 2022-08-04 Juan Gómez-Luna , Yuxin Guo , Sylvan Brocard , Julien Legriel , Remy Cimadomo , Geraldo F. Oliveira , Gagandeep Singh , Onur Mutlu

Modern data-intensive applications demand high computation capabilities with strict power constraints. Unfortunately, such applications suffer from a significant waste of both execution cycles and energy in current computing systems due to…

Hardware Architecture · Computer Science 2021-07-06 Gagandeep Singh , Mohammed Alser , Damla Senol Cali , Dionysios Diamantopoulos , Juan Gómez-Luna , Henk Corporaal , Onur Mutlu

In this paper, we present GradPIM, a processing-in-memory architecture which accelerates parameter updates of deep neural networks training. As one of processing-in-memory techniques that could be realized in the near future, we propose an…

Machine Learning · Computer Science 2021-02-16 Heesu Kim , Hanmin Park , Taehyun Kim , Kwanheum Cho , Eojin Lee , Soojung Ryu , Hyuk-Jae Lee , Kiyoung Choi , Jinho Lee

In the rapidly evolving domain of next generation sequencing and bioinformatics analysis, data generation is one aspect that is increasing at a concomitant rate. The burden associated with processing large amounts of sequencing data has…

Genomics · Quantitative Biology 2015-03-11 Matthew J. Wade , Thomas P. Curtis , Russell J. Davenport

Homomorphic encryption (HE) enables computation over encrypted data, offering strong privacy guarantees for untrusted computing environments. Practical adoption remains limited by high computational complexity, large ciphertext sizes, and…

Graph Neural Networks (GNNs) are emerging ML models to analyze graph-structure data. Graph Neural Network (GNN) execution involves both compute-intensive and memory-intensive kernels, the latter dominates the total time, being significantly…

Nanopore genome sequencing is the key to enabling personalized medicine, global food security, and virus surveillance. The state-of-the-art base-callers adopt deep neural networks (DNNs) to translate electrical signals generated by nanopore…

Hardware Architecture · Computer Science 2020-08-10 Qian Lou , Sarath Janga , Lei Jiang

Processing-in-memory (PIM) is a promising computing paradigm to tackle the "memory wall" challenge. However, PIM system-level benefits over traditional von Neumann architecture can be reduced when the memory array cannot fully store all the…

Hardware Architecture · Computer Science 2025-03-03 Peilin Chen , Xiaoxuan Yang

In-memory database query processing frequently involves substantial data transfers between the CPU and memory, leading to inefficiencies due to Von Neumann bottleneck. Processing-in-Memory (PIM) architectures offer a viable solution to…