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Related papers: Processing-in-memory for genomics workloads

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Novel technologies in genomics allow creating data in exascale dimension with relatively minor effort of human and laboratory and thus monetary resources compared to capabilities only a decade ago. While the availability of this data…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-11-10 Sandra Gesing , Thomas Richard Connor , Ian Taylor

Homomorphic encryption (HE) allows direct computations on encrypted data. Despite numerous research efforts, the practicality of HE schemes remains to be demonstrated. In this regard, the enormous size of ciphertexts involved in HE…

Cryptography and Security · Computer Science 2020-10-27 Dayane Reis , Jonathan Takeshita , Taeho Jung , Michael Niemier , Xiaobo Sharon Hu

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial…

Modern Artificial Intelligence (AI) applications are increasingly utilizing multi-tenant deep neural networks (DNNs), which lead to a significant rise in computing complexity and the need for computing parallelism. ReRAM-based…

Emerging Technologies · Computer Science 2024-08-12 Bojing Li , Duo Zhong , Xiang Chen , Chenchen Liu

Various processing-in-memory (PIM) accelerators based on various devices, micro-architectures, and interfaces have been proposed to accelerate deep neural networks (DNNs). How to deploy DNNs onto PIM-based accelerators is the key to explore…

Hardware Architecture · Computer Science 2024-11-15 Xiaotian Sun , Xinyu Wang , Wanqian Li , Yinhe Han , Xiaoming Chen

The computing wall and data movement challenges of deep neural networks (DNNs) have exposed the limitations of conventional CMOS-based DNN accelerators. Furthermore, the deep structure and large model size will make DNNs prohibitive to…

Signal Processing · Electrical Eng. & Systems 2019-12-12 Geng Yuan , Xiaolong Ma , Sheng Lin , Zhengang Li , Caiwen Ding

Processing-in-memory (PIM) is a transformative architectural paradigm designed to overcome the Von Neumann bottleneck. Among PIM architectures, digital SRAM-PIM emerges as a promising solution, offering significant advantages by directly…

Hardware Architecture · Computer Science 2025-06-13 Cenlin Duan , Jianlei Yang , Yikun Wang , Yiou Wang , Yingjie Qi , Xiaolin He , Bonan Yan , Xueyan Wang , Xiaotao Jia , Weisheng Zhao

The performance and efficiency of running large-scale datasets on traditional computing systems exhibit critical bottlenecks due to the existing "power wall" and "memory wall" problems. To resolve those problems, processing-in-memory (PIM)…

Hardware Architecture · Computer Science 2022-04-22 Yinglin Zhao , Jianlei Yang , Bing Li , Xingzhou Cheng , Xucheng Ye , Xueyan Wang , Xiaotao Jia , Zhaohao Wang , Youguang Zhang , Weisheng Zhao

Today's sequencing technology allows sequencing an individual genome within a few weeks for a fraction of the costs of the original Human Genome project. Genomics labs are faced with dozens of TB of data per week that have to be…

Databases · Computer Science 2009-09-15 Uwe Roehm , Jose Blakeley

Database search and clustering are fundamental components of many data analytics problems, such as mass spectrometry-driven proteomics. Traditional full clustering and search algorithms suffer from high resource usage and long latencies. We…

Databases · Computer Science 2025-11-25 Md Mizanur Rahaman Nayan , Zheyu Li , Flavio Ponzina , Sumukh Pinge , Tajana Rosing , Azad J. Naeemi

Mass spectrometry (MS) is essential for proteomics and metabolomics but faces impending challenges in efficiently processing the vast volumes of data. This paper introduces SpecPCM, an in-memory computing (IMC) accelerator designed to…

Hardware Architecture · Computer Science 2024-11-18 Keming Fan , Ashkan Moradifirouzabadi , Xiangjin Wu , Zheyu Li , Flavio Ponzina , Anton Persson , Eric Pop , Tajana Rosing , Mingu Kang

Recent research has sought to accelerate cryptographic hash functions as they are at the core of modern cryptography. Traditional designs, however, suffer from the von Neumann bottleneck that originates from the separation of processing and…

Hardware Architecture · Computer Science 2022-06-03 Batel Oved , Orian Leitersdorf , Ronny Ronen , Shahar Kvatinsky

Large-scale genomic workflows used in precision medicine can process datasets spanning tens to hundreds of gigabytes per sample, leading to high memory spikes, intensive disk I/O, and task failures due to out-of-memory errors. Simple static…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-21 Daniel Mas Montserrat , Ray Verma , Míriam Barrabés , Francisco M. de la Vega , Carlos D. Bustamante , Alexander G. Ioannidis

Read mapping is a fundamental, yet computationally-expensive step in many genomics applications. It is used to identify potential matches and differences between fragments (called reads) of a sequenced genome and an already known genome…

Processing-in-Memory (PIM) has emerged as a promising computing paradigm to address the memory wall and the fundamental bottleneck of the von Neumann architecture by reducing costly data movement between memory and processing units. As with…

Hardware Architecture · Computer Science 2025-12-02 Mahdi Aghaei , Saba Ebrahimi , Mohammad Saleh Arafati , Elham Cheshmikhani , Dara Rahmati , Saeid Gorgin , Jungrae Kim

Processing in-memory (PIM) is promising to accelerate neural networks (NNs) because it minimizes data movement and provides large computational parallelism. Similar to machine learning accelerators, application mapping, which determines the…

Hardware Architecture · Computer Science 2024-07-02 Xuan Wang , Minxuan Zhou , Tajana Rosing

Processing in memory (PiM) represents a promising computing paradigm to enhance performance of numerous data-intensive applications. Variants performing computing directly in emerging nonvolatile memories can deliver very high energy…

Edge devices equipped with computer vision must deal with vast amounts of sensory data with limited computing resources. Hence, researchers have been exploring different energy-efficient solutions such as near-sensor processing, in-sensor…

Image and Video Processing · Electrical Eng. & Systems 2023-01-24 Md Abdullah-Al Kaiser , Gourav Datta , Zixu Wang , Ajey P. Jacob , Peter A. Beerel , Akhilesh R. Jaiswal

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Spurred by widening gap between data processing speed and data communication speed in Von-Neumann computing architectures, some bioinformatic applications have harnessed the computational power of Processing-in-Memory (PIM) platforms.…

Hardware Architecture · Computer Science 2020-08-17 Shaahin Angizi , Naima Ahmed Fahmi , Wei Zhang , Deliang Fan
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