English
Related papers

Related papers: Improving Protein Sequence Design through Designab…

200 papers

Algorithms for machine learning-guided design, or design algorithms, use machine learning-based predictions to propose novel objects with desired property values. Given a new design task -- for example, to design novel proteins with high…

Machine Learning · Computer Science 2025-07-04 Clara Fannjiang , Ji Won Park

Human visual preferences are inherently multi-dimensional, encompassing aesthetics, detail fidelity, and semantic alignment. However, existing datasets provide only single, holistic annotations, resulting in severe label noise: images that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Xinxin Liu , Ming Li , Zonglin Lyu , Yuzhang Shang , Chen Chen

Direct Preference Optimization (DPO) has emerged as a simple and effective method for aligning large language models. However, its reliance on a fixed temperature parameter leads to suboptimal training on diverse preference data, causing…

Machine Learning · Computer Science 2025-10-08 Hyung Gyu Rho

Direct Preference Optimization (DPO) is a principled, scalable alternative to RLHF for aligning large language models from pairwise preferences, but its internal geometric footprint remains undercharacterized, limiting audits, checkpoint…

Machine Learning · Computer Science 2026-01-13 Arion Das , Partha Pratim Saha , Amit Dhanda , Vinija Jain , Aman Chadha , Amitava Das

Fairness in Continual Learning for Large Multimodal Models (LMMs) is an emerging yet underexplored challenge, particularly in the presence of imbalanced data distributions that can lead to biased model updates and suboptimal performance…

Machine Learning · Computer Science 2026-03-31 Thanh-Dat Truong , Huu-Thien Tran , Jackson Cothren , Bhiksha Raj , Khoa Luu

Direct Preference Optimization (DPO) has been proposed as a promising alternative to Proximal Policy Optimization (PPO) based Reinforcement Learning with Human Feedback (RLHF). However, empirical evaluations consistently reveal suboptimal…

Machine Learning · Computer Science 2025-03-03 Qinwei Ma , Jingzhe Shi , Can Jin , Jenq-Neng Hwang , Serge Belongie , Lei Li

Recent advancements have established Reinforcement Learning (RL) as a pivotal paradigm for aligning generative models with human intent. However, group-based optimization frameworks (e.g., GRPO) face a critical limitation: the rapid decay…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Sujie Hu , Chubin Chen , Jiashu Zhu , Jiahong Wu , Xiangxiang Chu , Xiu Li

Efficient preference optimization algorithms such as Direct Preference Optimization (DPO) have become a popular approach in aligning large language models (LLMs) with human preferences. These algorithms implicitly treat the LLM as a reward…

Computation and Language · Computer Science 2025-07-29 Tong Liu , Xiao Yu , Wenxuan Zhou , Jindong Gu , Volker Tresp

Generative Retrieval (GR) is rapidly transforming e-commerce search by replacing traditional multi-stage pipelines with the autoregressive decoding of structured Semantic IDs (SIDs). Despite this architectural efficiency, aligning GR models…

Information Retrieval · Computer Science 2026-04-29 Zhiguo Chen , Guohao Sun , Yiming Qiu , Xingzhi Yao , Mingming Li , Huimu Wang , Yangqi Zhang , Songlin Wang , Sulong Xu

To enhance controllability in text-to-image generation, ControlNet introduces image-based control signals, while ControlNet++ improves pixel-level cycle consistency between generated images and the input control signal. To avoid the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Zonglin Lyu , Ming Li , Xinxin Liu , Chen Chen

While likelihood-based generative models, particularly diffusion and autoregressive models, have achieved remarkable fidelity in visual generation, the maximum likelihood estimation (MLE) objective, which minimizes the forward KL…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Kaiwen Zheng , Yongxin Chen , Huayu Chen , Guande He , Ming-Yu Liu , Jun Zhu , Qinsheng Zhang

Aligning large language models (LLMs) with human preferences has gained significant attention, with Proximal Policy Optimization (PPO) as a standard yet computationally expensive method and Direct Preference Optimization (DPO) as a more…

Artificial Intelligence · Computer Science 2025-02-10 Yuzi Yan , Yibo Miao , Jialian Li , Yipin Zhang , Jian Xie , Zhijie Deng , Dong Yan

Designing functional protein sequences that satisfy multiple desired properties is a core research focus of protein engineering. Prior methods struggle with inability or inefficiency when dealing with numerous, often conflicting,…

Biomolecules · Quantitative Biology 2026-05-08 Zitai Kong , Yifan Dong , Yixuan Wu , Zhaokang Liang , Jian Wu , Hongxia Xu

Preference based alignment objectives implicitly assume that all human preferences are expressed with equal strength. In practice, however, preference strength varies across individuals and contexts -- a phenomenon established in behavioral…

Machine Learning · Computer Science 2026-01-13 Saki Imai , Pedram Heydari , Anthony Sicilia , Asteria Kaeberlein , Katherine Atwell , Malihe Alikhani

Direct Preference Optimization (DPO) is an efficient alignment technique that steers LLMs towards preferable outputs by training on preference data, bypassing the need for explicit reward models. Its simplicity enables easy adaptation to…

Direct Preference Optimization (DPO) and its variants have become standard for aligning Large Language Models due to their simplicity and offline stability. However, we identify two fundamental limitations. First, the optimal policy depends…

Artificial Intelligence · Computer Science 2026-02-10 Yu Li , Tian Lan , Zhengling Qi

Direct Preference Optimization (DPO) has been proposed as an effective and efficient alternative to reinforcement learning from human feedback (RLHF). In this paper, we propose a novel and enhanced version of DPO based on curriculum…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Nicu Sebe , Mubarak Shah

Offline paired preference optimization algorithms have become a popular approach for fine-tuning on preference data, outperforming traditional supervised fine-tuning in various tasks. However, traditional implementations often involve…

Machine Learning · Computer Science 2024-11-01 Franklin Wang , Sumanth Hegde

As the era of large language models (LLMs) unfolds, Preference Optimization (PO) methods have become a central approach to aligning LLMs with human preferences and improving performance. We propose Maximum a Posteriori Preference…

Software engineering presents complex, multi-step challenges for Large Language Models (LLMs), requiring reasoning over large codebases and coordinated tool use. The difficulty of these tasks is exemplified by benchmarks like SWE-bench,…

Artificial Intelligence · Computer Science 2026-02-05 Jiahao Yu , Zelei Cheng , Xian Wu , Xinyu Xing