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Large language models (LLMs) and LLM-based agents are increasingly deployed as assistants in planning and decision making, yet most existing systems are implicitly optimized for a single-principal interaction paradigm, in which the model is…

Computation and Language · Computer Science 2026-04-29 Shu Yang , Shenzhe Zhu , Hao Zhu , José Ramón Enríquez , Di Wang , Alex Pentland , Michiel A. Bakker , Jiaxin Pei

TThis paper argues that \textbf{a comprehensive vulnerability analysis is essential for building trustworthy Large Language Model-based Multi-Agent Systems (LLM-MAS)}. These systems, which consist of multiple LLM-powered agents working…

Cryptography and Security · Computer Science 2026-05-19 Pengfei He , Yue Xing , Juanhui Li , Shen Dong , Zhenwei Dai , Xianfeng Tang , Hui Liu , Han Xu , Zhen Xiang , Charu C. Aggarwal , Hui Liu

Numerous medical systems powered by Large Language Models (LLMs) have achieved remarkable progress in diverse healthcare tasks. However, research on their medication safety remains limited due to the lack of real world datasets, constrained…

Artificial Intelligence · Computer Science 2025-11-07 Jiahao Zhao , Luxin Xu , Minghuan Tan , Lichao Zhang , Ahmadreza Argha , Hamid Alinejad-Rokny , Min Yang

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP)…

Artificial Intelligence · Computer Science 2025-07-16 Yicong Wu , Ting Chen , Irit Hochberg , Zhoujian Sun , Ruth Edry , Zhengxing Huang , Mor Peleg

The integration of Large Language Models (LLMs) into healthcare applications offers promising advancements in medical diagnostics, treatment recommendations, and patient care. However, the susceptibility of LLMs to adversarial attacks poses…

Artificial Intelligence · Computer Science 2024-12-18 Yifan Yang , Qiao Jin , Furong Huang , Zhiyong Lu

A high volume of recent ML security literature focuses on attacks against aligned large language models (LLMs). These attacks may extract private information or coerce the model into producing harmful outputs. In real-world deployments,…

Machine Learning · Computer Science 2025-02-13 Ang Li , Yin Zhou , Vethavikashini Chithrra Raghuram , Tom Goldstein , Micah Goldblum

The integration of Large Language Models (LLMs) and Multi-modal Large Language Models (MLLMs) into mobile GUI agents has significantly enhanced user efficiency and experience. However, this advancement also introduces potential security…

Cryptography and Security · Computer Science 2025-03-18 Yulong Yang , Xinshan Yang , Shuaidong Li , Chenhao Lin , Zhengyu Zhao , Chao Shen , Tianwei Zhang

LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains…

Human-Computer Interaction · Computer Science 2025-08-26 Mithat Can Ozgun , Jiahuan Pei , Koen Hindriks , Lucia Donatelli , Qingzhi Liu , Junxiao Wang

Large Language Model (LLM)-powered agents demonstrate strong capabilities in autonomous task execution, tool use, and multi-step reasoning. However, their increasing autonomy also introduces a new attack surface: adversarial interactions…

Artificial Intelligence · Computer Science 2026-05-05 Sheldon Yu , Yingcheng Sun , Hanqing Guo , Julian McAuley , Qianqian Tong

Most LLM safety work studies single-agent models, but many real applications rely on multiple interacting agents. In these systems, prompt segmentation and inter-agent routing create attack surfaces that single-agent evaluations miss. We…

Multiagent Systems · Computer Science 2026-04-21 Nokimul Hasan Arif , Qian Lou , Mengxin Zheng

The growing adoption of large language models (LLMs) has led to a new paradigm in mobile computing--LLM-powered mobile AI agents--capable of decomposing and automating complex tasks directly on smartphones. However, the security…

Cryptography and Security · Computer Science 2025-05-21 Liangxuan Wu , Chao Wang , Tianming Liu , Yanjie Zhao , Haoyu Wang

Recent advances in Large Language Models (LLMs) have enabled multi-agent systems that simulate real-world interactions with near-human reasoning. While previous studies have extensively examined biases related to protected attributes such…

Artificial Intelligence · Computer Science 2025-06-03 Min Choi , Keonwoo Kim , Sungwon Chae , Sangyeob Baek

This paper proposes a novel architectural framework aimed at enhancing security and reliability in multi-agent systems (MAS). A central component of this framework is a network of Sentinel Agents, functioning as a distributed security layer…

Artificial Intelligence · Computer Science 2025-09-19 Diego Gosmar , Deborah A. Dahl

Clinical decision making (CDM) is a complex, dynamic process crucial to healthcare delivery, yet it remains a significant challenge for artificial intelligence systems. While Large Language Model (LLM)-based agents have been tested on…

Computation and Language · Computer Science 2025-10-13 Jie Liu , Wenxuan Wang , Zizhan Ma , Guolin Huang , Yihang SU , Kao-Jung Chang , Wenting Chen , Haoliang Li , Linlin Shen , Michael Lyu

Recent advances have enabled LLM-powered AI agents to autonomously execute complex tasks by combining language model reasoning with tools, memory, and web access. But can these systems be trusted to follow deployment policies in realistic…

The widespread deployment of LLM-based agents is likely to introduce a critical privacy threat: malicious agents that proactively engage others in multi-turn interactions to extract sensitive information. However, the evolving nature of…

Cryptography and Security · Computer Science 2026-05-11 Yanzhe Zhang , Diyi Yang

Autonomous agent frameworks built upon large language models (LLMs) are evolving into complex, tool-integrated, and continuously operating systems, introducing security risks beyond traditional prompt-level vulnerabilities. As this paradigm…

Cryptography and Security · Computer Science 2026-05-01 Luyao Xu , Xiang Chen

As Large Language Model (LLM) agents become more capable, their coordinated use in the form of multi-agent systems is anticipated to emerge as a practical paradigm. Prior work has examined the safety and misuse risks associated with agents.…

Artificial Intelligence · Computer Science 2026-02-26 Akshat Naik , Jay Culligan , Yarin Gal , Philip Torr , Rahaf Aljundi , Alasdair Paren , Adel Bibi

Large language models (LLMs) have achieved remarkable capabilities but remain vulnerable to adversarial prompts known as jailbreaks, which can bypass safety alignment and elicit harmful outputs. Despite growing efforts in LLM safety…

Cryptography and Security · Computer Science 2025-05-27 Guobin Shen , Dongcheng Zhao , Linghao Feng , Xiang He , Jihang Wang , Sicheng Shen , Haibo Tong , Yiting Dong , Jindong Li , Xiang Zheng , Yi Zeng

Large language models (LLMs) now mediate many web-based mental-health, crisis, and other emotionally sensitive services, yet their psychosocial safety in these settings remains poorly understood and weakly evaluated. We present DialogGuard,…

Artificial Intelligence · Computer Science 2025-12-03 Han Luo , Guy Laban