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Large language models (LLMs), despite their remarkable progress across various general domains, encounter significant barriers in medicine and healthcare. This field faces unique challenges such as domain-specific terminologies and…

Computation and Language · Computer Science 2024-06-06 Xiangru Tang , Anni Zou , Zhuosheng Zhang , Ziming Li , Yilun Zhao , Xingyao Zhang , Arman Cohan , Mark Gerstein

Addressing contextual privacy concerns remains challenging in interactive settings where large language models (LLMs) process information from multiple sources (e.g., summarizing meetings with private and public information). We introduce a…

Artificial Intelligence · Computer Science 2026-02-26 Wenkai Li , Liwen Sun , Zhenxiang Guan , Xuhui Zhou , Maarten Sap

Large Language Models (LLMs) are increasingly integrated into safety-critical workflows, yet existing security analyses remain fragmented and often isolate model behavior from the broader system context. This work introduces a goal-driven…

Cryptography and Security · Computer Science 2026-03-10 Neha Nagaraja , Hayretdin Bahsi

Large language models (LLMs) are increasingly utilized in healthcare applications. However, their deployment in clinical practice raises significant safety concerns, including the potential spread of harmful information. This study…

Cryptography and Security · Computer Science 2025-03-05 Hang Zhang , Qian Lou , Yanshan Wang

With the continuous development of large language models (LLMs), transformer-based models have made groundbreaking advances in numerous natural language processing (NLP) tasks, leading to the emergence of a series of agents that use LLMs as…

Artificial Intelligence · Computer Science 2024-11-15 Yuyou Gan , Yong Yang , Zhe Ma , Ping He , Rui Zeng , Yiming Wang , Qingming Li , Chunyi Zhou , Songze Li , Ting Wang , Yunjun Gao , Yingcai Wu , Shouling Ji

AI agents, predominantly powered by large language models (LLMs), are vulnerable to indirect prompt injection, in which malicious instructions embedded in untrusted data can trigger dangerous agent actions. This position paper discusses our…

Cryptography and Security · Computer Science 2026-04-01 Chong Xiang , Drew Zagieboylo , Shaona Ghosh , Sanjay Kariyappa , Kai Greshake , Hanshen Xiao , Chaowei Xiao , G. Edward Suh

Most discussions about Large Language Model (LLM) safety have focused on single-agent settings but multi-agent LLM systems now create novel adversarial risks because their behavior depends on communication between agents and decentralized…

Multiagent Systems · Computer Science 2025-10-10 Rana Muhammad Shahroz Khan , Zhen Tan , Sukwon Yun , Charles Fleming , Tianlong Chen

Machine learning (ML) underpins foundation models in finance, healthcare, and critical infrastructure, making them targets for data poisoning, model extraction, prompt injection, automated jailbreaking, and preference-guided black-box…

Cryptography and Security · Computer Science 2025-12-30 Armstrong Foundjem , Lionel Nganyewou Tidjon , Leuson Da Silva , Foutse Khomh

The rapid adoption of Large Language Model (LLM) agents and multi-agent systems enables remarkable capabilities in natural language processing and generation. However, these systems introduce security vulnerabilities that extend beyond…

Cryptography and Security · Computer Science 2026-05-12 Matteo Lupinacci , Francesco Aurelio Pironti , Francesco Blefari , Francesco Romeo , Luigi Arena , Angelo Furfaro

Powerful autonomous systems, which reason, plan, and converse using and between numerous tools and agents, are made possible by Large Language Models (LLMs), Vision-Language Models (VLMs), and new agentic AI systems, like LangChain and…

Cryptography and Security · Computer Science 2025-12-30 Toqeer Ali Syed , Mishal Ateeq Almutairi , Mahmoud Abdel Moaty

Embodied agents powered by large language models (LLMs) inherit advanced planning capabilities; however, their direct interaction with the physical world exposes them to safety vulnerabilities. In this work, we identify four key reasoning…

Artificial Intelligence · Computer Science 2025-10-01 Ruolin Chen , Yinqian Sun , Jihang Wang , Mingyang Lv , Qian Zhang , Yi Zeng

Security concerns related to Large Language Models (LLMs) have been extensively explored, yet the safety implications for Multimodal Large Language Models (MLLMs), particularly in medical contexts (MedMLLMs), remain insufficiently studied.…

Cryptography and Security · Computer Science 2024-08-22 Xijie Huang , Xinyuan Wang , Hantao Zhang , Yinghao Zhu , Jiawen Xi , Jingkun An , Hao Wang , Hao Liang , Chengwei Pan

Medical conversational AI (AI) plays a pivotal role in the development of safer and more effective medical dialogue systems. However, existing benchmarks and evaluation frameworks for assessing the information-gathering and diagnostic…

Computation and Language · Computer Science 2026-01-08 Lecheng Gong , Weimin Fang , Ting Yang , Dongjie Tao , Chunxiao Guo , Peng Wei , Bo Xie , Jinqun Guan , Zixiao Chen , Fang Shi , Jinjie Gu , Junwei Liu

The performance of large language model (LLM) agents depends critically on the execution harness, the system layer that orchestrates tool use, context management, and state persistence. Yet this same architectural centrality makes the…

Cryptography and Security · Computer Science 2026-05-12 Xixun Lin , Yang Liu , Yancheng Chen , Yongxuan Wu , Yucheng Ning , Yilong Liu , Nan Sun , Shun Zhang , Bin Chong , Chuan Zhou , Yanan Cao

We argue that LLM agent security is fundamentally an agent-human interaction (AHI) problem, not a purely algorithmic one. To substantiate this position, we conduct a systematic analysis of 59 academic papers, 21 production agent systems,…

Cryptography and Security · Computer Science 2026-05-26 Peiran Wang , Ying Li , Yuan Tian

As Large Language Models (LLMs) grow increasingly powerful, multi-agent systems are becoming more prevalent in modern AI applications. Most safety research, however, has focused on vulnerabilities in single-agent LLMs. These include prompt…

Multiagent Systems · Computer Science 2024-10-11 Donghyun Lee , Mo Tiwari

AI agents powered by large language models (LLMs) are being deployed at scale, yet we lack a systematic understanding of how the choice of backbone LLM affects agent security. The non-deterministic sequential nature of AI agents complicates…

Cryptography and Security · Computer Science 2026-02-25 Julia Bazinska , Max Mathys , Francesco Casucci , Mateo Rojas-Carulla , Xander Davies , Alexandra Souly , Niklas Pfister

As large language models (LLMs) evolve into autonomous "AI scientists," they promise transformative advances but introduce novel vulnerabilities, from potential "biosafety risks" to "dangerous explosions." Ensuring trustworthy deployment in…

Cryptography and Security · Computer Science 2026-03-20 Saket Sanjeev Chaturvedi , Joshua Bergerson , Tanwi Mallick

The integration of Large Language Models (LLMs) into healthcare demands a safety paradigm rooted in \textit{primum non nocere}. However, current alignment techniques rely on generic definitions of harm that fail to capture context-dependent…

Computers and Society · Computer Science 2025-12-01 Andrew Maranhão Ventura D'addario

Large language model (LLM) agents are vulnerable to prompt-injection attacks that propagate through multi-step workflows, tool interactions, and persistent context, making input-output filtering alone insufficient for reliable protection.…

Artificial Intelligence · Computer Science 2026-04-21 Hailin Liu , Eugene Ilyushin , Jie Ni , Min Zhu