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Applying machine learning to real-world medical data, e.g. from hospital archives, has the potential to revolutionize disease detection in brain images. However, detecting pathology in such heterogeneous cohorts is a difficult challenge.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Ana Lawry Aguila , Ayodeji Ijishakin , Juan Eugenio Iglesias , Tomomi Takenaga , Yukihiro Nomura , Takeharu Yoshikawa , Osamu Abe , Shouhei Hanaoka

Generative models have demonstrated significant success in anomaly detection and segmentation over the past decade. Recently, diffusion models have emerged as a powerful alternative, outperforming previous approaches such as GANs and VAEs.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Mehrdad Moradi , Marco Grasso , Bianca Maria Colosimo , Kamran Paynabar

The use of supervised deep learning techniques to detect pathologies in brain MRI scans can be challenging due to the diversity of brain anatomy and the need for annotated data sets. An alternative approach is to use unsupervised anomaly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Finn Behrendt , Debayan Bhattacharya , Julia Krüger , Roland Opfer , Alexander Schlaefer

Supervised deep learning techniques show promise in medical image analysis. However, they require comprehensive annotated data sets, which poses challenges, particularly for rare diseases. Consequently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Finn Behrendt , Debayan Bhattacharya , Lennart Maack , Julia Krüger , Roland Opfer , Robin Mieling , Alexander Schlaefer

Chest X-rays or chest radiography (CXR), commonly used for medical diagnostics, typically enables limited imaging compared to computed tomography (CT) scans, which offer more detailed and accurate three-dimensional data, particularly…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Noa Cahan , Eyal Klang , Galit Aviram , Yiftach Barash , Eli Konen , Raja Giryes , Hayit Greenspan

Reconstruction-based approaches have achieved remarkable outcomes in anomaly detection. The exceptional image reconstruction capabilities of recently popular diffusion models have sparked research efforts to utilize them for enhanced…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Haoyang He , Jiangning Zhang , Hongxu Chen , Xuhai Chen , Zhishan Li , Xu Chen , Yabiao Wang , Chengjie Wang , Lei Xie

This paper explores the utility of diffusion-based models for anomaly detection, focusing on their efficacy in identifying deviations in both compact and high-resolution datasets. Diffusion-based architectures, including Denoising Diffusion…

Machine Learning · Computer Science 2024-12-11 Aryan Bhosale , Samrat Mukherjee , Biplab Banerjee , Fabio Cuzzolin

Medical image understanding requires meticulous examination of fine visual details, with particular regions requiring additional attention. While radiologists build such expertise over years of experience, it is challenging for AI models to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Ying Jin , Zhuoran Zhou , Haoquan Fang , Jenq-Neng Hwang

Unsupervised anomaly detection (UAD) aims to find anomalous images by optimising a detector using a training set that contains only normal images. UAD approaches can be based on reconstruction methods, self-supervised approaches, and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-23 Yu Tian , Guansong Pang , Yuyuan Liu , Chong Wang , Yuanhong Chen , Fengbei Liu , Rajvinder Singh , Johan W Verjans , Mengyu Wang , Gustavo Carneiro

Advanced healthcare predictions offer significant improvements in patient outcomes by leveraging predictive analytics. Existing works primarily utilize various views of Electronic Health Record (EHR) data, such as diagnoses, lab tests, or…

Machine Learning · Computer Science 2025-05-20 Chuang Zhao , Hui Tang , Hongke Zhao , Xiaomeng Li

Contrastive Analysis (CA) detects anomalies by contrasting patterns unique to a target group (e.g., unhealthy subjects) from those in a background group (e.g., healthy subjects). In the context of brain MRIs, existing CA approaches rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Cristiano Patrício , Carlo Alberto Barbano , Attilio Fiandrotti , Riccardo Renzulli , Marco Grangetto , Luis F. Teixeira , João C. Neves

Health risk prediction is one of the fundamental tasks under predictive modeling in the medical domain, which aims to forecast the potential health risks that patients may face in the future using their historical Electronic Health Records…

Machine Learning · Computer Science 2023-10-09 Yuan Zhong , Suhan Cui , Jiaqi Wang , Xiaochen Wang , Ziyi Yin , Yaqing Wang , Houping Xiao , Mengdi Huai , Ting Wang , Fenglong Ma

Anomaly detection in medical imaging is a challenging task in contexts where abnormalities are not annotated. This problem can be addressed through unsupervised anomaly detection (UAD) methods, which identify features that do not match with…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Geoffroy Oudoumanessah , Carole Lartizien , Michel Dojat , Florence Forbes

Unsupervised Anomaly Detection (UAD) techniques aim to identify and localize anomalies without relying on annotations, only leveraging a model trained on a dataset known to be free of anomalies. Diffusion models learn to modify inputs $x$…

Computer Vision and Pattern Recognition · Computer Science 2024-03-06 Sergio Naval Marimont , Matthew Baugh , Vasilis Siomos , Christos Tzelepis , Bernhard Kainz , Giacomo Tarroni

The imperative for early detection of type 2 diabetes mellitus (T2DM) is challenged by its asymptomatic onset and dependence on suboptimal clinical diagnostic tests, contributing to its widespread global prevalence. While research into…

Machine Learning · Computer Science 2024-12-17 Sanjana Gundapaneni , Zhuo Zhi , Miguel Rodrigues

Known for their impressive performance in generative modeling, diffusion models are attractive candidates for density-based anomaly detection. This paper investigates different variations of diffusion modeling for unsupervised and…

Machine Learning · Computer Science 2026-05-11 Victor Livernoche , Vineet Jain , Yashar Hezaveh , Siamak Ravanbakhsh

Anomaly detection (AD) plays a pivotal role across diverse domains, including cybersecurity, finance, healthcare, and industrial manufacturing, by identifying unexpected patterns that deviate from established norms in real-world data.…

Machine Learning · Computer Science 2025-06-12 Yang Liu , Jing Liu , Chengfang Li , Rui Xi , Wenchao Li , Liang Cao , Jin Wang , Laurence T. Yang , Junsong Yuan , Wei Zhou

Unsupervised anomaly detection in medical images such as chest radiographs is stepping into the spotlight as it mitigates the scarcity of the labor-intensive and costly expert annotation of anomaly data. However, nearly all existing methods…

Computer Vision and Pattern Recognition · Computer Science 2023-07-31 Behzad Bozorgtabar , Dwarikanath Mahapatra , Jean-Philippe Thiran

In medical applications, weakly supervised anomaly detection methods are of great interest, as only image-level annotations are required for training. Current anomaly detection methods mainly rely on generative adversarial networks or…

Image and Video Processing · Electrical Eng. & Systems 2022-10-06 Julia Wolleb , Florentin Bieder , Robin Sandkühler , Philippe C. Cattin

Tables are an abundant form of data with use cases across all scientific fields. Real-world datasets often contain anomalous samples that can negatively affect downstream analysis. In this work, we only assume access to contaminated data…

Machine Learning · Computer Science 2023-07-25 Guy Zamberg , Moshe Salhov , Ofir Lindenbaum , Amir Averbuch