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Deep generative models, while revolutionizing fields like image and text generation, largely operate as opaque ``black boxes'', hindering human understanding, control, and alignment. While methods like sparse autoencoders (SAEs) show…

Machine Learning · Computer Science 2026-04-03 Lingjing Kong , Shaoan Xie , Guangyi Chen , Yuewen Sun , Xiangchen Song , Eric P. Xing , Kun Zhang

The widespread adoption of algorithmic decision-making systems has brought about the necessity to interpret the reasoning behind these decisions. The majority of these systems are complex black box models, and auxiliary models are often…

Human-Computer Interaction · Computer Science 2022-02-28 Md Naimul Hoque , Klaus Mueller

Early detection of melanoma is crucial for preventing severe complications and increasing the chances of successful treatment. Existing deep learning approaches for melanoma skin lesion diagnosis are deemed black-box models, as they omit…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Cristiano Patrício , João C. Neves , Luís F. Teixeira

The proliferation of deepfake technologies poses urgent challenges and serious risks to digital integrity, particularly within critical sectors such as forensics, journalism, and the legal system. While existing detection systems have made…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Shahroz Tariq , Simon S. Woo , Priyanka Singh , Irena Irmalasari , Saakshi Gupta , Dev Gupta

With the increasing adoption of predictive models trained using machine learning across a wide range of high-stakes applications, e.g., health care, security, criminal justice, finance, and education, there is a growing need for effective…

Machine Learning · Computer Science 2020-08-04 Aria Khademi , Vasant Honavar

Recent work has demonstrated the promise of combining local explanations with active learning for understanding and supervising black-box models. Here we show that, under specific conditions, these algorithms may misrepresent the quality of…

Artificial Intelligence · Computer Science 2020-07-21 Teodora Popordanoska , Mohit Kumar , Stefano Teso

Recently, artificial intelligence and machine learning in general have demonstrated remarkable performances in many tasks, from image processing to natural language processing, especially with the advent of deep learning. Along with…

Machine Learning · Computer Science 2020-10-23 Erico Tjoa , Cuntai Guan

We propose Black Box Explanations through Transparent Approximations (BETA), a novel model agnostic framework for explaining the behavior of any black-box classifier by simultaneously optimizing for fidelity to the original model and…

Artificial Intelligence · Computer Science 2017-07-06 Himabindu Lakkaraju , Ece Kamar , Rich Caruana , Jure Leskovec

Healthcare professionals need effective ways to use, understand, and validate AI-driven clinical decision support systems. Existing systems face two key limitations: complex visualizations and a lack of grounding in scientific evidence. We…

Human-Computer Interaction · Computer Science 2025-07-08 Reza Samimi , Aditya Bhattacharya , Lucija Gosak , Gregor Stiglic , Katrien Verbert

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

The rapid adoption of complex Artificial Intelligence (AI) and Machine Learning (ML) models has led to their characterization as black boxes due to the difficulty of explaining their internal decision-making processes. This lack of…

Machine Learning · Computer Science 2026-01-13 Silvia Ruiz-España , Laura Arnal , François Signol , Juan-Carlos Perez-Cortes , Joaquim Arlandis

Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…

Black box models in machine learning have demonstrated excellent predictive performance in complex problems and high-dimensional settings. However, their lack of transparency and interpretability restrict the applicability of such models in…

Machine Learning · Computer Science 2020-06-09 Numair Sani , Jaron Lee , Razieh Nabi , Ilya Shpitser

The financial industry faces a significant challenge modeling and risk portfolios: balancing the predictability of advanced machine learning models, neural network models, and explainability required by regulatory entities (such as Office…

Machine Learning · Computer Science 2025-11-10 Rongbin Ye , Jiaqi Chen

This paper explores the significant impact of AI-based medical devices, including wearables, telemedicine, large language models, and digital twins, on clinical decision support systems. It emphasizes the importance of producing outcomes…

Artificial Intelligence · Computer Science 2024-04-11 Elham Nasarian , Roohallah Alizadehsani , U. Rajendra Acharya , Kwok-Leung Tsui

When it comes to complex machine learning models, commonly referred to as black boxes, understanding the underlying decision making process is crucial for domains such as healthcare and financial services, and also when it is used in…

Machine Learning · Computer Science 2020-12-02 Jürgen Dieber , Sabrina Kirrane

The rise of agentic AI systems, where agents collaborate to perform diverse tasks, poses new challenges with observing, analyzing and optimizing their behavior. Traditional evaluation and benchmarking approaches struggle to handle the…

Artificial Intelligence · Computer Science 2025-03-11 Dany Moshkovich , Hadar Mulian , Sergey Zeltyn , Natti Eder , Inna Skarbovsky , Roy Abitbol

From self-driving vehicles and back-flipping robots to virtual assistants who book our next appointment at the hair salon or at that restaurant for dinner - machine learning systems are becoming increasingly ubiquitous. The main reason for…

Machine Learning · Computer Science 2018-08-16 Milo Honegger

This paper develops a new approach for estimating an interpretable, relational model of a black-box autonomous agent that can plan and act. Our main contributions are a new paradigm for estimating such models using a minimal query interface…

Artificial Intelligence · Computer Science 2021-04-12 Pulkit Verma , Shashank Rao Marpally , Siddharth Srivastava