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Black-box heterogeneous treatment effect (HTE) models are increasingly being used to create personalized policies that assign individuals to their optimal treatments. However, they are difficult to understand, and can be burdensome to…

Machine Learning · Computer Science 2022-08-09 Han Wu , Sarah Tan , Weiwei Li , Mia Garrard , Adam Obeng , Drew Dimmery , Shaun Singh , Hanson Wang , Daniel Jiang , Eytan Bakshy

The recent series of innovations in deep learning (DL) have shown enormous potential to impact individuals and society, both positively and negatively. The DL models utilizing massive computing power and enormous datasets have significantly…

Artificial Intelligence · Computer Science 2020-12-15 Manas Gaur , Keyur Faldu , Amit Sheth

Deep learning models show significant potential for advancing AI-assisted medical diagnostics, particularly in detecting lung cancer through medical image modalities such as chest X-rays. However, the black-box nature of these models poses…

Machine Learning · Computer Science 2025-03-31 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan

Recent developments in Artificial Intelligence (AI) and their applications in critical industries such as healthcare, fin-tech and cybersecurity have led to a surge in research in explainability in AI. Innovative research methods are being…

Artificial Intelligence · Computer Science 2025-08-26 Aoun E Muhammad , Kin-Choong Yow , Nebojsa Bacanin-Dzakula , Muhammad Attique Khan

We present an interpretable companion model for any pre-trained black-box classifiers. The idea is that for any input, a user can decide to either receive a prediction from the black-box model, with high accuracy but no explanations, or…

Machine Learning · Statistics 2020-02-12 Danqing Pan , Tong Wang , Satoshi Hara

Understanding why machine learning models behave the way they do empowers both system designers and end-users in many ways: in model selection, feature engineering, in order to trust and act upon the predictions, and in more intuitive user…

Machine Learning · Statistics 2016-06-20 Marco Tulio Ribeiro , Sameer Singh , Carlos Guestrin

Understanding the decision-making process of Deep Reinforcement Learning agents remains a key challenge for deploying these systems in safety-critical and multi-agent environments. While prior explainability methods like StateMask, have…

Artificial Intelligence · Computer Science 2025-10-02 Maisha Maliha , Dean Hougen

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Chenglong Wang , Yinqiao Yi , Yida Wang , Chengxiu Zhang , Yun Liu , Kensaku Mori , Mei Yuan , Guang Yang

Artificial intelligence (AI) provides considerable opportunities to assist human work. However, one crucial challenge of human-AI collaboration is that many AI algorithms operate in a black-box manner where the way how the AI makes…

Human-Computer Interaction · Computer Science 2024-06-13 Julian Senoner , Simon Schallmoser , Bernhard Kratzwald , Stefan Feuerriegel , Torbjørn Netland

The goal of Explainable AI (XAI) is to design methods to provide insights into the reasoning process of black-box models, such as deep neural networks, in order to explain them to humans. Social science research states that such…

Artificial Intelligence · Computer Science 2024-07-24 Van Bach Nguyen , Jörg Schlötterer , Christin Seifert

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

This paper provides empirical concerns about post-hoc explanations of black-box ML models, one of the major trends in AI explainability (XAI), by showing its lack of interpretability and societal consequences. Using a representative…

Human-Computer Interaction · Computer Science 2021-10-01 Jean-Marie John-Mathews

Most deep learning recommendation models operate as black boxes, relying on latent representations that obscure their decision process. This lack of intrinsic interpretability raises concerns in applications that require transparency and…

Information Retrieval · Computer Science 2026-04-07 Jinhao Pan , Bowen Wei , Ziwei Zhu

Explanations for AI models in high-stakes domains like medicine often lack verifiability, which can hinder trust. To address this, we propose an interactive agent that produces explanations through an auditable sequence of actions. The…

Artificial Intelligence · Computer Science 2025-11-04 Yuhang Huang , Zekai Lin , Fan Zhong , Lei Liu

Motivation: The size of available omics datasets is steadily increasing with technological advancement in recent years. While this increase in sample size can be used to improve the performance of relevant prediction tasks in healthcare,…

Quantitative Methods · Quantitative Biology 2023-05-04 Jonas C. Ditz , Bernhard Reuter , Nico Pfeifer

Interpretable surrogates of black-box predictors trained on high-dimensional tabular datasets can struggle to generate comprehensible explanations in the presence of correlated variables. We propose a model-agnostic interpretable surrogate…

Machine Learning · Statistics 2019-06-05 Xavier Renard , Nicolas Woloszko , Jonathan Aigrain , Marcin Detyniecki

Indecipherable black boxes are common in machine learning (ML), but applications increasingly require explainable artificial intelligence (XAI). The core of XAI is to establish transparent and interpretable data-driven algorithms. This work…

Optimization and Control · Mathematics 2023-06-13 Howard Heaton , Samy Wu Fung

Recently, interpretable machine learning has re-explored concept bottleneck models (CBM). An advantage of this model class is the user's ability to intervene on predicted concept values, affecting the downstream output. In this work, we…

Machine Learning · Computer Science 2024-10-29 Sonia Laguna , Ričards Marcinkevičs , Moritz Vandenhirtz , Julia E. Vogt

Explainability and interpretability of AI models is an essential factor affecting the safety of AI. While various explainable AI (XAI) approaches aim at mitigating the lack of transparency in deep networks, the evidence of the effectiveness…

Artificial Intelligence · Computer Science 2020-03-03 Kamran Alipour , Jurgen P. Schulze , Yi Yao , Avi Ziskind , Giedrius Burachas