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Interpretability is significant in computational pathology, leading to the development of multimodal information integration from histopathological image and corresponding text data.However, existing multimodal methods have limited…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Kangcheng Zhou , Jun Jiang , Qing Zhang , Shuang Zheng , Qingli Li , Shugong Xu

The diagnosis of pathological images is often limited by expert availability and regional disparities, highlighting the importance of automated diagnosis using Vision-Language Models (VLMs). Traditional multimodal models typically emphasize…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Jianyu Wu , Hao Yang , Xinhua Zeng , Guibing He , Zhiyu Chen , Zihui Li , Xiaochuan Zhang , Yangyang Ma , Run Fang , Yang Liu

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable…

AI tools in pathology have improved screening throughput, standardized quantification, and revealed prognostic patterns that inform treatment. However, adoption remains limited because most systems still lack the human-readable reasoning…

Artificial Intelligence · Computer Science 2025-11-18 Yunqi Hong , Johnson Kao , Liam Edwards , Nein-Tzu Liu , Chung-Yen Huang , Alex Oliveira-Kowaleski , Cho-Jui Hsieh , Neil Y. C. Lin

Recent advances in vision language models (VLMs) have enabled broad progress in the general medical field. However, pathology still remains a more challenging subdomain, with current pathology specific VLMs exhibiting limitations in both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Wenchuan Zhang , Penghao Zhang , Jingru Guo , Tao Cheng , Jie Chen , Shuwan Zhang , Zhang Zhang , Yuhao Yi , Hong Bu

Multimodal large models have shown great potential in automating pathology image analysis. However, current multimodal models for gastrointestinal pathology are constrained by both data quality and reasoning transparency: pervasive noise…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Minxi Ouyang , Lianghui Zhu , Yaqing Bao , Qiang Huang , Jingli Ouyang , Tian Guan , Xitong Ling , Jiawen Li , Song Duan , Wenbin Dai , Li Zheng , Xuemei Zhang , Yonghong He

Reasoning is a hallmark of human intelligence, enabling adaptive decision-making in complex and unfamiliar scenarios. In contrast, machine intelligence remains bound to training data, lacking the ability to dynamically refine solutions at…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Shaheer U. Saeed , Yipei Wang , Veeru Kasivisvanathan , Brian R. Davidson , Matthew J. Clarkson , Yipeng Hu , Daniel C. Alexander

Effective token compression remains a critical challenge for scaling models to handle increasingly complex and diverse datasets. A novel mechanism based on contextual reinforcement is introduced, dynamically adjusting token importance…

Computation and Language · Computer Science 2025-08-11 Naderdel Piero , Zacharias Cromwell , Nathaniel Wainwright , Matthias Nethercott

Although Vision Language Models (VLMs) have shown strong generalization in medical imaging, pathology presents unique challenges due to ultra-high resolution, complex tissue structures, and nuanced clinical semantics. These factors make…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Wenchuan Zhang , Jingru Guo , Hengzhe Zhang , Penghao Zhang , Jie Chen , Shuwan Zhang , Zhang Zhang , Yuhao Yi , Hong Bu

Radiologists highly desire fully automated AI for radiology report generation (R2G), yet existing approaches fall short in clinical utility. Reinforcement learning (RL) holds potential to address these shortcomings, but its adoption in this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Zilin Lu , Ruifeng Yuan , Weiwei Cao , Wanxing Chang , Zhongyu Wei , Sinuo Wang , Yong Xia , Ling Zhang , Jianpeng Zhang

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Zhe Xu , Ziyi Liu , Junlin Hou , Jiabo Ma , Cheng Jin , Yihui Wang , Zhixuan Chen , Zhengyu Zhang , Fuxiang Huang , Zhengrui Guo , Fengtao Zhou , Yingxue Xu , Xi Wang , Ronald Cheong Kin Chan , Li Liang , Hao Chen

Developing 3D vision-language models with robust clinical reasoning remains a challenge due to the inherent complexity of volumetric medical imaging, the tendency of models to overfit superficial report patterns, and the lack of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Haoran Lai , Zihang Jiang , Kun Zhang , Qingsong Yao , Rongsheng Wang , Zhiyang He , Xiaodong Tao , Wei Wei , Shaohua Kevin Zhou

Fully supervised segmentation methods require a large training cohort of already segmented images, providing information at the pixel level of each image. We present a method to automatically segment and model pathologies in medical images,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Simon Andermatt , Antal Horváth , Simon Pezold , Philippe Cattin

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

The growing integration of vision-language models (VLMs) in medical applications offers promising support for diagnostic reasoning. However, current medical VLMs often face limitations in generalization, transparency, and computational…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Tan-Hanh Pham , Chris Ngo

Visual explanation methods have an important role in the prognosis of the patients where the annotated data is limited or unavailable. There have been several attempts to use gradient-based attribution methods to localize pathology from…

Image and Video Processing · Electrical Eng. & Systems 2021-06-24 Ugur Demir , Ismail Irmakci , Elif Keles , Ahmet Topcu , Ziyue Xu , Concetto Spampinato , Sachin Jambawalikar , Evrim Turkbey , Baris Turkbey , Ulas Bagci

Large language models have achieved strong performance on medical reasoning benchmarks, yet their deployment in clinical settings demands rigorous verification to ensure factual accuracy. While reward models offer a scalable approach for…

Artificial Intelligence · Computer Science 2026-01-29 Hang Zhang , Ruheng Wang , Yuelyu Ji , Mingu Kwak , Xizhi Wu , Chenyu Li , Li Zhang , Wenqi Shi , Yifan Peng , Yanshan Wang

Pathological diagnosis remains the definitive standard for identifying tumors. The rise of multimodal large models has simplified the process of integrating image analysis with textual descriptions. Despite this advancement, the substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Xiaomin Wu , Rui Xu , Pengchen Wei , Wenkang Qin , Peixiang Huang , Ziheng Li , Lin Luo

Machine Learning has been applied to pathology images in research and clinical practice with promising outcomes. However, standard ML models often lack the rigorous evaluation required for clinical decisions. Machine learning techniques for…

Image and Video Processing · Electrical Eng. & Systems 2022-04-19 Syed Ashar Javed , Dinkar Juyal , Zahil Shanis , Shreya Chakraborty , Harsha Pokkalla , Aaditya Prakash
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