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Spatial transcriptomics aims to connect high-resolution histology images with spatially resolved gene expression. To achieve better performance on downstream tasks such as gene expression prediction, large-scale pre-training is required to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Jiahe Qian , Yaoyu Fang , Ziqiao Weng , Xinkun Wang , Lee A. Cooper , Bo Zhou

Spatial Transcriptomics (ST) enables the measurement of gene expression while preserving spatial information, offering critical insights into tissue architecture and disease pathology. Recent developments have explored the use of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Hai Dang Nguyen , Nguyen Dang Huy Pham , The Minh Duc Nguyen , Dac Thai Nguyen , Hang Thi Nguyen , Duong M. Nguyen

The rapid development of spatial transcriptomics(ST) enables the measurement of gene expression at spatial resolution, making it possible to simultaneously profile the gene expression, spatial locations of spots, and the matched…

Artificial Intelligence · Computer Science 2024-06-19 Changxi Chi , Hang Shi , Qi Zhu , Daoqiang Zhang , Wei Shao

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Susceptibility tensor imaging (STI) is an emerging magnetic resonance imaging technique that characterizes the anisotropic tissue magnetic susceptibility with a second-order tensor model. STI has the potential to provide information for…

Image and Video Processing · Electrical Eng. & Systems 2022-09-13 Zhenghan Fang , Kuo-Wei Lai , Peter van Zijl , Xu Li , Jeremias Sulam

Spatial-temporal Map (STMap)-based methods have shown great potential to process high-angle videos for vehicle trajectory reconstruction, which can meet the needs of various data-driven modeling and imitation learning applications. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-03-07 Tianya T. Zhang Ph. D. , Peter J. Jin Ph. D. , Han Zhou , Benedetto Piccoli , Ph. D

Multi-modal object Re-Identification (ReID) aims to exploit complementary information from different modalities to retrieve specific objects. However, existing methods often rely on hard token filtering or simple fusion strategies, which…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Xingguo Xu , Zhanyu Liu , Weixiang Zhou , Yuansheng Gao , Junjie Cao , Yuhao Wang , Jixiang Luo , Dell Zhang

Cardiac magnetic resonance (CMR) imaging and computed tomography (CT) are two common non-invasive imaging methods for assessing patients with cardiovascular disease. CMR typically acquires multiple sparse 2D slices, with unavoidable…

Image and Video Processing · Electrical Eng. & Systems 2024-08-15 Yiyang Xu , Hao Xu , Matthew Sinclair , Esther Puyol-Antón , Steven A Niederer , Amedeo Chiribiri , Steven E Williams , Michelle C Williams , Alistair A Young

We study image segmentation in the biological domain, particularly trait segmentation from specimen images (e.g., butterfly wing stripes, beetle elytra). This fine-grained task is crucial for understanding the biology of organisms, but it…

Vision Transformers (ViTs) have achieved remarkable success in computer vision tasks. However, their potential in rotation-sensitive scenarios has not been fully explored, and this limitation may be inherently attributed to the lack of…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hongtian Yu , Yunjie Tian , Qixiang Ye , Yunfan Liu

The integration of AI in digital pathology, particularly in whole slide image (WSI) and spatial transcriptomics (ST) analysis, holds immense potential for enhancing our understanding of diseases. Despite challenges such as training pattern…

Quantitative Methods · Quantitative Biology 2024-11-18 Chao-Hui Huang , Sara Lichtarge , Diane Fernandez

Unpaired image-to-image translation has emerged as a crucial technique in medical imaging, enabling cross-modality synthesis, domain adaptation, and data augmentation without costly paired datasets. Yet, existing approaches often distort…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Zihao Chen , Yi Zhou , Xudong Jiang , Li Chen , Leopold Schmetterer , Bingyao Tan , Jun Cheng

Spatial Transcriptomics is a novel technology that aligns histology images with spatially resolved gene expression profiles. Although groundbreaking, it struggles with gene capture yielding high corruption in acquired data. Given potential…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Gabriel Mejia , Daniela Ruiz , Paula Cárdenas , Leonardo Manrique , Daniela Vega , Pablo Arbeláez

Hyperspectral image (HSI) denoising is a crucial preprocessing procedure for the subsequent HSI applications. Unfortunately, though witnessing the development of deep learning in HSI denoising area, existing convolution-based methods face…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Miaoyu Li , Ying Fu , Yulun Zhang

Recent developments in spatial omics technologies have enabled the generation of high dimensional molecular data, such as transcriptomes, proteomes, and epigenomes, within their spatial tissue context, either through coprofiling on the same…

Quantitative Methods · Quantitative Biology 2026-01-21 Esra Busra Isik , Yusuf Hakan Usta , Haozhe Liu , Maryam Riazi , William Roach , Hongpeng Zhou , Magnus Rattray , Sokratia Georgaka

Magnetic Resonance Imaging (MRI) is a technology for non-invasive imaging of anatomical features in detail. It can help in functional analysis of organs of a specimen but it is very costly. In this work, methods for (i) virtual…

Image and Video Processing · Electrical Eng. & Systems 2023-03-17 Somoballi Ghoshal , Shremoyee Goswami , Amlan Chakrabarti , Susmita Sur-Kolay

Spatial transcriptomics offers spatially resolved gene expression profiling within tissue sections, but its cost and limited throughput hinder large-scale deployment. To extend this capability to routine practice, recent computational…

Machine Learning · Computer Science 2026-05-07 Keunho Byeon , Jin Tae Kwak

Understanding cellular trajectories via time-resolved single-cell transcriptomics is vital for studying development, regeneration, and disease. A key challenge is inferring continuous trajectories from discrete snapshots. Biological…

MRI and CT are essential clinical cross-sectional imaging techniques for diagnosing complex conditions. However, large 3D datasets with annotations for deep learning are scarce. While methods like DINOv2 are encouraging for 2D image…

Image and Video Processing · Electrical Eng. & Systems 2025-07-10 Gustav Müller-Franzes , Firas Khader , Robert Siepmann , Tianyu Han , Jakob Nikolas Kather , Sven Nebelung , Daniel Truhn

A large portion of volumetric medical data, especially magnetic resonance imaging (MRI) data, is anisotropic, as the through-plane resolution is typically much lower than the in-plane resolution. Both 3D and purely 2D deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Alex Ling Yu Hung , Haoxin Zheng , Kai Zhao , Xiaoxi Du , Kaifeng Pang , Qi Miao , Steven S. Raman , Demetri Terzopoulos , Kyunghyun Sung
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