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Individual patient data (IPD) are essential for statistical inference in clinical research. However, privacy concerns, high data-sharing costs, and restrictive access often make IPD unavailable. Conventional synthetic data generation…

Applications · Statistics 2025-09-23 Zixuan Zhao , Zexin Ren , Guannan Zhai , Feifang Hu , Will Ma , En Xie , Qian Shi

Fulfilling the promise of precision medicine requires accurately and precisely classifying disease states. For cancer, this includes prediction of survival time from a surfeit of covariates. Such data presents an opportunity for improved…

Applications · Statistics 2017-06-22 Shannon R. McCurdy , Annette Molinaro , Lior Pachter

Data privacy has increasingly become a daunting challenge because it limits data availability, which is essential in estimating statistical models such as generalized linear mixed models. Access to personal data often involves considerable…

Methodology · Statistics 2026-05-05 Marie Analiz April Limpoco , Christel Faes , Niel Hens

Combining data from varied sources has considerable potential for knowledge discovery: collaborating data parties can mine data in an expanded feature space, allowing them to explore a larger range of scientific questions. However, data…

Machine Learning · Computer Science 2019-11-11 Erik-Jan van Kesteren , Chang Sun , Daniel L. Oberski , Michel Dumontier , Lianne Ippel

In this paper, we analyze the problem of optimally allocating resources in a distributed and privacy-preserving manner. We propose a novel distributed optimal resource allocation algorithm with privacy-preserving guarantees, which operates…

Systems and Control · Electrical Eng. & Systems 2022-07-19 Jakob Nylöf , Apostolos I. Rikos , Sebin Gracy , Karl H. Johansson

Survival data with time-varying covariates are common in practice. If relevant, they can improve on the estimation of survival function. However, the traditional survival forests - conditional inference forest, relative risk forest and…

Applications · Statistics 2022-06-06 Weichi Yao , Halina Frydman , Denis Larocque , Jeffrey S. Simonoff

Covariate imbalance between treatment groups makes it difficult to compare cumulative incidence curves in competing risk analyses. In this paper we discuss different methods to estimate adjusted cumulative incidence curves including inverse…

In this work, we study the problem of clustering survival data $-$ a challenging and so far under-explored task. We introduce a novel semi-supervised probabilistic approach to cluster survival data by leveraging recent advances in…

Increasingly, medical research is dependent on data collected for non-research purposes, such as electronic health records data (EHR). EHR data and other large databases can be prone to measurement error in key exposures, and unadjusted…

Methodology · Statistics 2020-05-13 Kyunghee Han , Thomas Lumley , Bryan E. Shepherd , Pamela A. Shaw

In statistics, it is important to have realistic data sets available for a particular context to allow an appropriate and objective method comparison. For many use cases, benchmark data sets for method comparison are already available…

Applications · Statistics 2024-05-30 Maria Thurow , Ina Dormuth , Christina Sauer , Marc Ditzhaus , Markus Pauly

We envision AI marketplaces to be platforms where consumers, with very less data for a target task, can obtain a relevant model by accessing many private data sources with vast number of data samples. One of the key challenges is to…

Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and…

Methodology · Statistics 2025-05-09 Zhiwei Zhang , Ya Wang , Dong Xi

This paper presents a novel approach to classical linear regression, enabling model computation from data streams or in a distributed setting while preserving data privacy in federated environments. We extend this framework to generalized…

Computation · Statistics 2026-05-29 Daniel Tinoco , Raquel Menezes , Carlos Baquero

We propose a new class of multivariate survival models based on archimedean copulas with margins modeled by the Yang and Prentice (YP) model. The Ali-Mikhail-Haq (AMH), Clayton, Frank, Gumbel-Hougaard (GH), and Joe copulas are employed to…

Methodology · Statistics 2022-03-08 W. D. R. Miranda Filho , F. N. Demarqui

Privacy-preserving model co-training in medical research is often hindered by server-dependent architectures incompatible with protected hospital data systems and by the predominant focus on relative effect measures (hazard ratios) which…

Machine Learning · Statistics 2026-01-22 Ziwen Wang , Siqi Li , Marcus Eng Hock Ong , Nan Liu

Distributed high dimensional mean estimation is a common aggregation routine used often in distributed optimization methods. Most of these applications call for a communication-constrained setting where vectors, whose mean is to be…

Machine Learning · Statistics 2026-01-28 Harsh Vardhan , Arya Mazumdar

Early outbreak data analysis is critical for informing about their potential impact and interventions. However, data obtained early in outbreaks are often sensitive and subject to strict privacy restrictions. Thus, federated analysis, which…

Applications · Statistics 2026-01-27 Simon Busch-Moreno , Moritz U. G. Kraemer

In medical and biological research, longitudinal data and survival data types are commonly seen. Traditional statistical models mostly consider to deal with either of the data types, such as linear mixed models for longitudinal data, and…

Methodology · Statistics 2021-07-12 Jizi Shangguan

A Bayesian multivariate model with a structured covariance matrix for multi-way nested data is proposed. This flexible modeling framework allows for positive and for negative associations among clustered observations, and generalizes the…

Methodology · Statistics 2024-08-27 Stef Baas , Richard J. Boucherie , Jean-Paul Fox

Various privacy-preserving frameworks that respect the individual's privacy in the analysis of data have been developed in recent years. However, available model classes such as simple statistics or generalized linear models lack the…

Machine Learning · Statistics 2023-03-13 Daniel Schalk , Bernd Bischl , David Rügamer
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