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Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Large language models (LLMs) have shown impressive capabilities in natural language processing tasks, including dialogue generation. This research aims to conduct a novel comparative analysis of two prominent techniques, fine-tuning with…

We present an advanced approach to medical question-answering (QA) services, using fine-tuned Large Language Models (LLMs) to improve the accuracy and reliability of healthcare information. Our study focuses on optimizing models like…

Computation and Language · Computer Science 2024-10-22 Ali Anaissi , Ali Braytee , Junaid Akram

Recently years have witnessed a rapid development of large language models (LLMs). Despite the strong ability in many language-understanding tasks, the heavy computational burden largely restricts the application of LLMs especially when one…

Machine Learning · Computer Science 2023-10-10 Yuhui Xu , Lingxi Xie , Xiaotao Gu , Xin Chen , Heng Chang , Hengheng Zhang , Zhengsu Chen , Xiaopeng Zhang , Qi Tian

Large Language Models (LLMs) such as GPT-4 and LLaMA have demonstrated remarkable reasoning abilities but require significant computational resources for fine-tuning. This paper presents a resource-efficient fine-tuning approach for…

Computation and Language · Computer Science 2025-10-07 Imran Mansha

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

This study presents an innovative enhancement to retrieval-augmented generation (RAG) systems by seamlessly integrating fine-tuned large language models (LLMs) with vector databases. This integration capitalizes on the combined strengths of…

Information Retrieval · Computer Science 2024-02-28 Keshav Rangan , Yiqiao Yin

Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing…

Computation and Language · Computer Science 2026-04-27 Xiaodi Li , Yang Xiao , Munhwan Lee , Konstantinos Leventakos , Young J. Juhn , David Jones , Terence T. Sio , Wei Liu , Maria Vassilaki , Nansu Zong

Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify…

Computation and Language · Computer Science 2024-08-19 Yucheng Shi , Shaochen Xu , Tianze Yang , Zhengliang Liu , Tianming Liu , Quanzheng Li , Xiang Li , Ninghao Liu

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim

Large Language Models (LLMs) have demonstrated impressive performance across various domains. However, the enormous number of model parameters makes fine-tuning challenging, significantly limiting their application and deployment. Existing…

Machine Learning · Computer Science 2025-07-23 Ao Shen , Qiang Wang , Zhiquan Lai , Xionglve Li , Dongsheng Li

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

This study aims to innovatively explore adaptive applications of large language models (LLM) in urban renewal. It also aims to improve its performance and text generation quality for knowledge question-answering (QA) tasks. Based on the…

Computation and Language · Computer Science 2023-11-28 Xi Wang , Xianyao Ling , Tom Zhang , Xuecao Li , Shaolan Wang , Zhixing Li , Liang Zhang , Peng Gong

Deploying Large Language Models (LLMs) for healthcare question answering requires robust methods to ensure accuracy and reliability. This work introduces Query-Based Retrieval Augmented Generation (QB-RAG), a framework for enhancing…

Machine Learning · Computer Science 2025-07-31 Eric Yang , Jonathan Amar , Jong Ha Lee , Bhawesh Kumar , Yugang Jia

Large Language Models(LLMs) hold promise for improving healthcare access in low-resource settings, but their effectiveness in African primary care remains underexplored. We present a methodology for creating a benchmark dataset and…

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Large Language Models (LLMs) have transformed both everyday life and scientific research. However, adapting LLMs from general-purpose models to specialized tasks remains challenging, particularly in resource-constrained environments.…

Machine Learning · Computer Science 2025-09-12 Hao Zhang , Bo Huang , Zhenjia Li , Xi Xiao , Hui Yi Leong , Zumeng Zhang , Xinwei Long , Tianyang Wang , Hao Xu

We propose a memory-efficient finetuning algorithm for large language models (LLMs) that supports finetuning LLMs with 65B parameters in 2/3/4-bit precision on as little as one 24GB GPU. Our method, modular low-rank adaptation (ModuLoRA),…

Machine Learning · Computer Science 2024-03-12 Junjie Yin , Jiahao Dong , Yingheng Wang , Christopher De Sa , Volodymyr Kuleshov

Generating physician letters is a time-consuming task in daily clinical practice. This study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving…

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