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Accurate and efficient question-answering systems are essential for delivering high-quality patient care in the medical field. While Large Language Models (LLMs) have made remarkable strides across various domains, they continue to face…

Computation and Language · Computer Science 2025-01-22 Hang Yang , Hao Chen , Hui Guo , Yineng Chen , Ching-Sheng Lin , Shu Hu , Jinrong Hu , Xi Wu , Xin Wang

Fine-tuning large language models (LLMs) with low-rank adaptation (LoRA) is a cost-effective way to incorporate information from a specific dataset. However, when a problem requires incorporating information from multiple datasets - as in…

Machine Learning · Computer Science 2026-04-03 Liyi Zhang , Jake Snell , Thomas L. Griffiths

Large language models (LLMs) typically utilize the top-k contexts from a retriever in retrieval-augmented generation (RAG). In this work, we propose a novel instruction fine-tuning framework RankRAG, which instruction-tunes a single LLM for…

Computation and Language · Computer Science 2024-07-03 Yue Yu , Wei Ping , Zihan Liu , Boxin Wang , Jiaxuan You , Chao Zhang , Mohammad Shoeybi , Bryan Catanzaro

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Recent studies show that large language models (LLMs) struggle with technical standards in telecommunications. We propose a fine-tuned retrieval-augmented generation (RAG) system based on the Phi-2 small language model (SLM) to serve as an…

Computation and Language · Computer Science 2025-01-17 Omar Erak , Nouf Alabbasi , Omar Alhussein , Ismail Lotfi , Amr Hussein , Sami Muhaidat , Merouane Debbah

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Fine-tuning Large Language Models (LLMs) for clinical Natural Language Processing (NLP) poses significant challenges due to domain gap, limited data, and stringent hardware constraints. In this study, we evaluate four adapter…

Computation and Language · Computer Science 2025-07-29 Thanh-Dung Le , Ti Ti Nguyen , Vu Nguyen Ha , Symeon Chatzinotas , Philippe Jouvet , Rita Noumeir

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external…

Computation and Language · Computer Science 2025-02-20 Yucheng Shi , Tianze Yang , Canyu Chen , Quanzheng Li , Tianming Liu , Xiang Li , Ninghao Liu

Large language models (LLMs) often generate outdated or inaccurate information based on static training datasets. Retrieval-augmented generation (RAG) mitigates this by integrating outside data sources. While previous RAG systems used…

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Low-Rank Adaptation (LoRA) is a crucial method for efficiently fine-tuning large language models (LLMs), with its effectiveness influenced by two key factors: rank selection and weight initialization. While numerous LoRA variants have been…

Machine Learning · Computer Science 2025-10-27 Haonan He , Peng Ye , Yuchen Ren , Yuan Yuan , Luyang Zhou , Shucun Ju , Lei Chen

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Fine-tuning helps large language models (LLM) recover degraded information and enhance task performance. Although Low-Rank Adaptation (LoRA) is widely used and effective for fine-tuning, we have observed that its scaling factor can limit or…

Machine Learning · Computer Science 2025-01-14 Jun Liu , Zhenglun Kong , Peiyan Dong , Changdi Yang , Xuan Shen , Pu Zhao , Hao Tang , Geng Yuan , Wei Niu , Wenbin Zhang , Xue Lin , Dong Huang , Yanzhi Wang

As Large Language Models (LLMs) are increasingly integrated into healthcare to address complex inquiries, ensuring their reliability remains a critical challenge. Recent studies have highlighted that generic LLMs often struggle in clinical…

Computation and Language · Computer Science 2026-04-01 Bian Sun , Zhenjian Wang , Orvill de la Torre , Zirui Wang

The persistent challenge of medical image synthesis posed by the scarcity of annotated data and the need to synthesize `missing modalities' for multi-modal analysis, underscored the imperative development of effective synthesis methods.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-15 Yuchen Mao , Hongwei Li , Wei Pang , Giorgos Papanastasiou , Guang Yang , Chengjia Wang

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Large language models (LLMs) are increasingly recognized as valuable tools across the medical environment, supporting clinical, research, and administrative workflows. However, strict privacy and network security regulations in hospital…

Computation and Language · Computer Science 2026-01-09 Seokhwan Ko , Donghyeon Lee , Jaewoo Chun , Hyungsoo Han , Junghwan Cho

Fine-tuning Large Language Models (LLMs) has become a crucial technique for adapting pre-trained models to downstream tasks. However, the enormous size of LLMs poses significant challenges in terms of computational complexity and resource…

Computation and Language · Computer Science 2024-10-28 Yifei Zhang , Hao Zhu , Aiwei Liu , Han Yu , Piotr Koniusz , Irwin King

Large Language Models (LLMs) consistently excel in diverse medical Natural Language Processing (NLP) tasks, yet their substantial computational requirements often limit deployment in real-world healthcare settings. In this work, we…

Computation and Language · Computer Science 2026-02-20 Pietro Ferrazzi , Mattia Franzin , Alberto Lavelli , Bernardo Magnini