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Multimodal alignment of histopathology encoders with transcriptomic and genomic data has been shown to significantly improve performance in downstream diagnostic tasks. Hematological cytology is unique in that visual single-cell evaluation…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Muhammed Furkan Dasdelen , Fatih Ozlugedik , Ilaria Looser , Rao Muhammad Umer , Christian Pohlkamp , Carsten Marr

Achieving deep alignment between vision and language remains a central challenge for Multimodal Large Language Models (MLLMs). These models often fail to fully leverage visual input, defaulting to strong language priors. Our approach first…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Aarti Ghatkesar , Ganesh Venkatesh

Multimodal Large Language Models (MLLMs) have achieved impressive progress in natural image reasoning, yet their potential in medical imaging remains underexplored, especially in clinical anatomical surgical images. Anatomy understanding…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Ziyang Song , Zelin Zang , Zuyao Chen , Xusheng Liang , Dong Yi , Jinlin Wu , Hongbin Liu , Jiebo Luo , Zhen. Lei

Accurately grounding regions of interest (ROIs) is critical for diagnosis and treatment planning in medical imaging. While multimodal large language models (MLLMs) combine visual perception with natural language, current medical-grounding…

Computer Vision and Pattern Recognition · Computer Science 2026-02-19 Zhonghao Yan , Muxi Diao , Yuxuan Yang , Ruoyan Jing , Jiayuan Xu , Kaizhou Zhang , Lele Yang , Yanxi Liu , Kongming Liang , Zhanyu Ma

Healthcare professionals need effective ways to use, understand, and validate AI-driven clinical decision support systems. Existing systems face two key limitations: complex visualizations and a lack of grounding in scientific evidence. We…

Human-Computer Interaction · Computer Science 2025-07-08 Reza Samimi , Aditya Bhattacharya , Lucija Gosak , Gregor Stiglic , Katrien Verbert

Although large language models perform well in understanding and responding to user intent, their performance in specialized domains such as Traditional Chinese Medicine (TCM) remains limited due to lack of expertise. In addition,…

Computation and Language · Computer Science 2024-11-05 Song Yu , Xiaofei Xu , Fangfei Xu , Li Li

Accurate disease interpretation from radiology remains challenging due to imaging heterogeneity. Achieving expert-level diagnostic decisions requires integration of subtle image features with clinical knowledge. Yet major vision-language…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Difei Gu , Yunhe Gao , Mu Zhou , Dimitris Metaxas

Current medical retrieval benchmarks primarily emphasize lexical or shallow semantic similarity, overlooking the reasoning-intensive demands that are central to clinical decision-making. In practice, physicians often retrieve authoritative…

Information Retrieval · Computer Science 2026-04-07 Xiangxu Zhang , Lei Li , Xiao Zhou , Zheng Liu

Recently, Artificial Intelligence (AI)-based algorithms have revolutionized the medical image segmentation processes. Thus, the precise segmentation of organs and their lesions may contribute to an efficient diagnostics process and a more…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Janusz Szczepanski , Agnieszka Pregowska

Vision-language pre-training (VLP) has great potential for developing multifunctional and general medical diagnostic capabilities. However, aligning medical images with a low signal-to-noise ratio (SNR) to reports with a high SNR presents a…

Image and Video Processing · Electrical Eng. & Systems 2025-08-07 Weiwei Cao , Jianpeng Zhang , Zhongyi Shui , Sinuo Wang , Zeli Chen , Xi Li , Le Lu , Xianghua Ye , Tingbo Liang , Qi Zhang , Ling Zhang

Recently, reinforcement learning (RL)-based tuning has shifted the trajectory of Multimodal Large Language Models (MLLMs), particularly following the introduction of Group Relative Policy Optimization (GRPO). However, directly applying it…

Computation and Language · Computer Science 2025-05-21 Wenhui Zhu , Xuanzhao Dong , Xin Li , Peijie Qiu , Xiwen Chen , Abolfazl Razi , Aris Sotiras , Yi Su , Yalin Wang

Recent progress in deep learning has significantly advanced CT image analysis, particularly for segmentation tasks. However, these advances are largely confined to image-level pattern recognition, with most methods lacking explicit…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Yuyuan Liu , Can Peng , Yingyu Yang , Qianye Yang , Cheng Ouyang , J. Alison Noble

Search engines enable the retrieval of unknown information with texts. However, traditional methods fall short when it comes to understanding unfamiliar visual content, such as identifying an object that the model has never seen before.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Zhixin Zhang , Yiyuan Zhang , Xiaohan Ding , Xiangyu Yue

In high-stakes medical applications, consistent answering across diverse question phrasings is essential for reliable diagnosis. However, we reveal that current Medical Vision-Language Models (Med-VLMs) exhibit concerning fragility in…

Computation and Language · Computer Science 2025-08-27 Songtao Jiang , Yuxi Chen , Sibo Song , Yan Zhang , Yeying Jin , Yang Feng , Jian Wu , Zuozhu Liu

Autoregressive modeling has driven major advances in multimodal AI, yet its application to medical imaging remains constrained by the absence of a unified image tokenizer that simultaneously preserves fine-grained anatomical structures and…

Image and Video Processing · Electrical Eng. & Systems 2026-04-02 Chenglong Ma , Yuanfeng Ji , Jin Ye , Zilong Li , Chenhui Wang , Junzhi Ning , Wei Li , Lihao Liu , Qiushan Guo , Tianbin Li , Junjun He , Hongming Shan

Automated 3D CT diagnosis empowers clinicians to make timely, evidence-based decisions by enhancing diagnostic accuracy and workflow efficiency. While multimodal large language models (MLLMs) exhibit promising performance in visual-language…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Yanzhao Shi , Xiaodan Zhang , Junzhong Ji , Haoning Jiang , Chengxin Zheng , Yinong Wang , Liangqiong Qu

The patient-centered medical dialogue systems strive to offer diagnostic interpretation services to users who are less knowledgeable about medical knowledge, through emphasizing the importance of providing responses specific to the…

Computation and Language · Computer Science 2023-10-19 Chengfeng Dou , Zhi Jin , Wenping Jiao , Haiyan Zhao , Zhenwei Tao , Yongqiang Zhao

Cross-Modal sponsored search displays multi-modal advertisements (ads) when consumers look for desired products by natural language queries in search engines. Since multi-modal ads bring complementary details for query-ads matching, the…

Computer Vision and Pattern Recognition · Computer Science 2023-09-29 Yuanmin Tang , Jing Yu , Keke Gai , Yujing Wang , Yue Hu , Gang Xiong , Qi Wu

Diagnostic imaging studies are an increasingly important component of the workup and management of acutely presenting patients. However, ordering appropriate imaging studies according to evidence-based medical guidelines is a challenging…

Machine Learning · Computer Science 2025-08-06 Michael S. Yao , Allison Chae , Charles E. Kahn , Walter R. Witschey , James C. Gee , Hersh Sagreiya , Osbert Bastani

While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of specific modalities is prevalent in clinical practice, severely degrading the performance of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Tianling Liu , Lequan Yu , Tong Han , Liang Wan
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