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We push the boundaries of electronic structure-based \textit{ab-initio} molecular dynamics (AIMD) beyond 100 million atoms. This scale is otherwise barely reachable with classical force-field methods or novel neural network and machine…

Performing data-intensive tasks in the von Neumann architecture is challenging to achieve both high performance and power efficiency due to the memory wall bottleneck. Computing-in-memory (CiM) is a promising mitigation approach by enabling…

Hardware Architecture · Computer Science 2024-04-03 Guodong Yin , Mufeng Zhou , Yiming Chen , Wenjun Tang , Zekun Yang , Mingyen Lee , Xirui Du , Jinshan Yue , Jiaxin Liu , Huazhong Yang , Yongpan Liu , Xueqing Li

The human brain simultaneously optimizes synaptic weights and topology by growing, pruning, and strengthening synapses while performing all computation entirely in memory. In contrast, modern artificial-intelligence systems separate weight…

Hardware Architecture · Computer Science 2025-06-17 Songqi Wang , Yue Zhang , Jia Chen , Xinyuan Zhang , Yi Li , Ning Lin , Yangu He , Jichang Yang , Yingjie Yu , Yi Li , Zhongrui Wang , Xiaojuan Qi , Han Wang

SNNs are an active research domain towards energy efficient machine intelligence. Compared to conventional ANNs, SNNs use temporal spike data and bio-plausible neuronal activation functions such as Leaky-Integrate Fire/Integrate Fire…

Neural and Evolutionary Computing · Computer Science 2022-10-25 Abhishek Moitra , Abhiroop Bhattacharjee , Runcong Kuang , Gokul Krishnan , Yu Cao , Priyadarshini Panda

Classical computing is beginning to encounter fundamental limits of energy efficiency. This presents a challenge that can no longer be solved by strategies such as increasing circuit density or refining standard semiconductor processes. The…

Hardware Architecture · Computer Science 2026-04-07 Keshava Katti , Pratik Chaudhari , Deep Jariwala

To realize the full potential of quantum computers, we must mitigate qubit errors by developing noise-aware algorithms, compilers, and architectures. Thus, simulating quantum programs on high-performance computing (HPC) systems with…

Quantum Physics · Physics 2025-05-20 Meng Wang , Swamit Tannu , Prashant J. Nair

Mass spectrometry (MS) is essential for proteomics and metabolomics but faces impending challenges in efficiently processing the vast volumes of data. This paper introduces SpecPCM, an in-memory computing (IMC) accelerator designed to…

Hardware Architecture · Computer Science 2024-11-18 Keming Fan , Ashkan Moradifirouzabadi , Xiangjin Wu , Zheyu Li , Flavio Ponzina , Anton Persson , Eric Pop , Tajana Rosing , Mingu Kang

Processing in memory (PIM) moves computation into memories with the goal of improving throughput and energy-efficiency compared to traditional von Neumann-based architectures. Most existing PIM architectures are either general-purpose but…

Hardware Architecture · Computer Science 2019-07-23 Oscar Castañeda , Maria Bobbett , Alexandra Gallyas-Sanhueza , Christoph Studer

Computing-in-Memory (CIM) macros have gained popularity for deep learning acceleration due to their highly parallel computation and low power consumption. However, limited macro size and ADC precision introduce throughput and accuracy…

Hardware Architecture · Computer Science 2026-05-01 Ming-Han Lin , Tian-Sheuan Chang

Accelerating end-to-end inference of transformer-based large language models (LLMs) is a critical component of AI services in datacenters. However, diverse compute characteristics of end-to-end LLM inference present challenges as previously…

The progress in neuromorphic computing is fueled by the development of novel nonvolatile memories capable of storing analog information and implementing neural computation efficiently. However, like most other analog circuits, these devices…

Emerging Technologies · Computer Science 2021-07-12 Z. Fahimi , M. R. Mahmoodi , M. Klachko , H. Nili , H. Kim , D. B. Strukov

The ever-increasing computation complexity of fast-growing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory…

Hardware Architecture · Computer Science 2021-07-21 Kaining Zhou , Yangshuo He , Rui Xiao , Kejie Huang

Content Addressable Memories (CAMs) are considered a key-enabler for in-memory computing (IMC). IMC shows order of magnitude improvement in energy efficiency and throughput compared to traditional computing techniques. Recently, analog CAMs…

Hardware Architecture · Computer Science 2022-03-07 Jinane Bazzi , Jana Sweidan , Mohammed E. Fouda , Rouwaida Kanj , Ahmed M. Eltawil

Digital Computing-in-Memory (DCIM) is an innovative technology that integrates multiply-accumulation (MAC) logic directly into memory arrays to enhance the performance of modern AI computing. However, the need for customized memory cells…

In recent years, the space community has been exploring the possibilities of Artificial Intelligence (AI), specifically Artificial Neural Networks (ANNs), for a variety of on board applications. However, this development is limited by the…

Hardware Architecture · Computer Science 2025-09-03 Zacharia A. Rudge , Dario Izzo , Moritz Fieback , Anteneh Gebregiorgis , Said Hamdioui , Dominik Dold

CPU simulators are vital for computer architecture research, primarily for estimating performance under different programs. This poses challenges for fast and accurate simulation of modern CPUs, especially in multi-core systems. Modern CPU…

Performance · Computer Science 2025-10-14 Buqing Xu , Jianfeng Zhu , Yichi Zhang , Qinyi Cai , Guanhua Li , Shaojun Wei , Leibo Liu

Spiking Neural Networks (SNNs) are bio-plausible models that hold great potential for realizing energy-efficient implementations of sequential tasks on resource-constrained edge devices. However, commercial edge platforms based on standard…

Neural and Evolutionary Computing · Computer Science 2023-09-26 Marco Paul E. Apolinario , Adarsh Kumar Kosta , Utkarsh Saxena , Kaushik Roy

In-memory computing (IMC) on a monolithic chip for deep learning faces dramatic challenges on area, yield, and on-chip interconnection cost due to the ever-increasing model sizes. 2.5D integration or chiplet-based architectures interconnect…

Machine Learning · Computer Science 2021-08-23 Gokul Krishnan , Sumit K. Mandal , Manvitha Pannala , Chaitali Chakrabarti , Jae-sun Seo , Umit Y. Ogras , Yu Cao

Designing lightweight convolutional neural network (CNN) models is an active research area in edge AI. Compute-in-memory (CIM) provides a new computing paradigm to alleviate time and energy consumption caused by data transfer in von Neumann…

Hardware Architecture · Computer Science 2025-08-19 Wenyong Zhou , Yuan Ren , Jiajun Zhou , Tianshu Hou , Ngai Wong

Triangle counting (TC) is a fundamental problem in graph analysis and has found numerous applications, which motivates many TC acceleration solutions in the traditional computing platforms like GPU and FPGA. However, these approaches suffer…

Hardware Architecture · Computer Science 2020-07-22 Xueyan Wang , Jianlei Yang , Yinglin Zhao , Yingjie Qi , Meichen Liu , Xingzhou Cheng , Xiaotao Jia , Xiaoming Chen , Gang Qu , Weisheng Zhao
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