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Cardiac arrhythmogenesis is governed by complex electromechanical interactions that are not directly observable in vivo, motivating the development of non-invasive computational approaches for reconstructing three-dimensional activation…

Medical Physics · Physics 2026-03-05 Nathan Dermul , Hans Dierckx

The rhythmic pumping motion of the heart stands as a cornerstone in life, as it circulates blood to the entire human body through a series of carefully timed contractions of the individual chambers. Changes in the size, shape and movement…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Kristine Sørensen , Paula Diez , Jan Margeta , Yasmin El Youssef , Michael Pham , Jonas Jalili Pedersen , Tobias Kühl , Ole de Backer , Klaus Kofoed , Oscar Camara , Rasmus Paulsen

Parameter estimation and uncertainty quantification are crucial in computational cardiology, as they enable the construction of digital twins that faithfully replicate the behavior of physical patients. Robust and efficient mathematical…

Numerical Analysis · Mathematics 2022-10-07 Matteo Salvador , Francesco Regazzoni , Luca Dede' , Alfio Quarteroni

Cardiovascular modeling has rapidly advanced over the past few decades due to the rising needs for health tracking and early detection of cardiovascular diseases. While 1-D arterial models offer an attractive compromise between…

This article presents a graph neural network (GNN) based surrogate modeling approach for fluid-acoustic shape optimization. The GNN model transforms mesh-based simulations into a computational graph, enabling global prediction of pressure…

Fluid Dynamics · Physics 2024-12-24 Farnoosh Hadizadeh , Wrik Mallik , Rajeev K. Jaiman

In this contribution we propose a data-driven surrogate model for the prediction of magnetic stray fields in two-dimensional random micro-heterogeneous materials. Since data driven models require thousands of training data sets, FEM…

Numerical Analysis · Mathematics 2023-04-11 Rainer Niekamp , Johanna Niemann , Maximilian Reichel , Hongbin Zhang , Jörg Schröder

Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines.…

Image and Video Processing · Electrical Eng. & Systems 2020-02-12 Sven Koehler , Animesh Tandon , Tarique Hussain , Heiner Latus , Thomas Pickardt , Samir Sarikouch , Philipp Beerbaum , Gerald Greil , Sandy Engelhardt , Ivo Wolf

Deep fully convolutional neural network (FCN) based architectures have shown great potential in medical image segmentation. However, such architectures usually have millions of parameters and inadequate number of training samples leading to…

Computer Vision and Pattern Recognition · Computer Science 2018-01-17 Mahendra Khened , Varghese Alex Kollerathu , Ganapathy Krishnamurthi

Accurate and robust whole heart substructure segmentation is crucial in developing clinical applications, such as computer-aided diagnosis and computer-aided surgery. However, segmentation of different heart substructures is challenging…

Image and Video Processing · Electrical Eng. & Systems 2021-02-04 Tarun Kanti Ghosh , Md. Kamrul Hasan , Shidhartho Roy , Md. Ashraful Alam , Eklas Hossain , Mohiuddin Ahmad

Neural network surrogate models have emerged as a promising approach to model solution fields for a wide variety of boundary value problems encountered in physical modeling. Stochastic problems represent an area of particularly high…

Machine Learning · Statistics 2026-05-18 Noah Wade , Kirubel Teferra

Computational modeling of the brain has become a key part of understanding how the brain clears metabolic waste, but patient-specific modeling on a significant scale is still out of reach with current methods. We introduce a novel approach…

Quantitative Methods · Quantitative Biology 2025-06-12 Andreas Solheim , Geir Ringstand , Per Kristian Eide , Kent-Andre Mardal

In the framework of reduced basis methods, we recently introduced a new certified hierarchical and adaptive surrogate model, which can be used for efficient approximation of input-output maps that are governed by parametrized partial…

Numerical Analysis · Mathematics 2023-03-01 Tizian Wenzel , Bernard Haasdonk , Hendrik Kleikamp , Mario Ohlberger , Felix Schindler

Hemodynamic quantities are valuable biomedical risk factors for cardiovascular pathology such as atherosclerosis. Non-invasive, in-vivo measurement of these quantities can only be performed using a select number of modalities that are not…

Quantitative Methods · Quantitative Biology 2026-02-23 Julian Suk , Dieuwertje Alblas , Barbara A. Hutten , Albert Wiegman , Christoph Brune , Pim van Ooij , Jelmer M. Wolterink

Thrombosis involves processes spanning large-scale fluid flow to sub-cellular events such as platelet activation. Traditional CFD approaches often treat blood as a continuum, which can limit their ability to capture these microscale…

Fluid Dynamics · Physics 2025-03-18 Marco Laudato , Luca Manzari , Khemraj Shukla

Continuum robots enable dexterous manipulation in constrained environments, but require accurate and efficient models for real-time manipulation and control. Traditional physics-based models can be computationally expensive and may suffer…

Robotics · Computer Science 2026-05-20 Branden Frieden , James M. Ferguson , Alan Kuntz , Varun Shankar

Accurate cardiac motion estimation from cine cardiac magnetic resonance (CMR) images is vital for assessing cardiac function and detecting its abnormalities. Existing methods often struggle to capture heart motion accurately because they…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Reza Akbari Movahed , Abuzar Rezaee , Arezoo Zakeri , Colin Berry , Edmond S. L. Ho , Ali Gooya

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the formulation and numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential,…

Computational Physics · Physics 2021-01-27 Stefania Fresca , Andrea Manzoni , Luca Dedè , Alfio Quarteroni

The computational models for geophysical flows are computationally very expensive to employ in multi-query tasks such as data assimilation, uncertainty quantification, and hence surrogate models sought to alleviate the computational burden…

Computational Physics · Physics 2022-01-10 Suraj Pawar , Omer San , Gary G. Yen

During the COVID-19 crisis, mechanistic models have guided evidence-based decision making. However, time-critical decisions in a dynamical environment limit the time available to gather supporting evidence. We address this bottleneck by…

Machine Learning · Computer Science 2026-01-15 Agatha Schmidt , Henrik Zunker , Alexander Heinlein , Martin J. Kühn

Convolutional neural network (CNN) based segmentation methods provide an efficient and automated way for clinicians to assess the structure and function of the heart in cardiac MR images. While CNNs can generally perform the segmentation…