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Many experiments in biological and medical sciences currently use multiphoton microscopy as a core imaging technique. To date, solid-state lasers are most commonly used as excitation beam sources. However, the most demanding applications…
Multi-photon processes are the essence of nonlinear optics. Optical harmonics generation and multi-photon absorption, ionization, polymerization or spectroscopy are widely used in practical applications. Generally, the rate of an n-photon…
Multi-photon microscopy has played a significant role in biological imaging since it allows to observe living tissues with improved penetration depth and excellent sectioning effect. Multi-photon microscopy relies on multi-photon…
Multiphoton microscopes employ femtosecond lasers as light sources because the high peak power of the ultrashort pulse allows for multiphoton excitation of fluorescence in the examined sample. However, such short pulses are susceptible to…
We demonstrate a significant resolution enhancement beyond the conventional limit in multiphoton microscopy (MPM) using saturated excitation of fluorescence. Our technique achieves super-resolved imaging by temporally modulating the…
Multiphoton femtosecond coherent control of is used for implementing innovative photo-induced analog coherent computation that generally might be a basis for future "smart hardware". The specific implemented computational task the…
Multiphoton processes of absorption photoluminescence have enabled a wide range of applications including three-dimensional microfabrication, data storage, and biological imaging. While the applications of two-photon and three-photon…
We show that the modulation of the phases of the laser beams of ultra-short pulses leads to modulation of the two photon fluorescence intensity. The phase modulation technique when used in multi-photon microscopy can improve the signal to…
An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multi-photon microscopy for…
We greatly expand the application of multiphoton microscopy to geological investigations by using a tightly focused femtosecond laser beam to excite fluorescent emissions among minimally prepared rock and mineral samples. This new finding…
We present and implement a new scheme for extended multi-channel selective femtosecond coherent control based on symmetry properties of the excitation channels. Here, an atomic non-resonant two-photon absorption channel is coherently…
We combine different wavelengths from an intense high-order harmonics source with variable delay at the focus of a split-mirror interferometer to conduct pump-probe experiments on gas-phase molecules. We report measurements of the time…
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron…
Multiphoton microscopy has enabled us to image cellular dynamics in vivo. However, the excitation wavelength for imaging with commercially available lasers is mostly limited between 650-1040 nm. Here we develop a femtosecond fiber laser…
Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…
We experimentally demonstrate a novel nonlinear effect in optical fibers: upconversion luminescence generation excited by multiphoton absorption of femtosecond infrared pulses. We directly estimate the average number of photons involved in…
Research on multimode optical fibers is arousing a growing interest, for their capability to transport high-power laser beams, coupled with novel nonlinear optics-based applications. However, when beam intensities exceed a certain critical…
Fluorescence microscopy is an important and extensively utilised tool for imaging biological systems. However, the image resolution that can be obtained has a limit as defined through the laws of diffraction. Demand for improved resolution…
Progress in electron-beam spectroscopies has recently enabled the study of optical excitations with combined space, energy and time resolution in the nanometer, millielectronvolt and femtosecond domain, thus providing unique access into…
Multi-photon interference reveals strictly non-classical phenomena. Its applications range from fundamental tests of quantum mechanics to photonic quantum information processing, where a significant fraction of key experiments achieved so…