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This paper addresses the decomposition of biochemical networks into functional modules that preserve their dynamic properties upon interconnection with other modules, which permits the inference of network behavior from the properties of…

Molecular Networks · Quantitative Biology 2014-12-03 Hari Sivakumar , Stephen R. Proulx , João P. Hespanha

Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological…

Statistical Mechanics · Physics 2009-11-10 A. Gamba , D. Ambrosi , A. Coniglio , A. de Candia , S. Di Talia , E. Giraudo , G. Serini , L. Preziosi , F. Bussolino

Mixtures of particles that interact through phoretic effects are known to aggregate if they belong to species that exhibit attractive self-interactions. We study self-organization in a model metabolic cycle composed of three species of…

Soft Condensed Matter · Physics 2023-09-29 Vincent Ouazan-Reboul , Ramin Golestanian , Jaime Agudo-Canalejo

We propose a model to show the self-assembling of network-like structures between a set of nodes without using preexisting positional information or long-range attraction of the nodes. The model is based on Brownian agents that are capable…

Statistical Mechanics · Physics 2009-11-07 Frank Schweitzer , Benno Tilch

Many biological systems collectively construct complex, adaptive, and functional architectures, where function emerges from bottom-up building processes rather than top-down planning or centralized control. However, general strategies for…

Soft Condensed Matter · Physics 2026-04-15 Andrew Slezak , Varda F. Hagh

Inspired by active shape morphing in developing tissues and biomaterials, we investigate two generic mechanochemical models where the deformations of a thin elastic sheet are driven by, and in turn affect, the concentration gradients of a…

Soft Condensed Matter · Physics 2021-07-14 Andrei Zakharov , Kinjal Dasbiswas

While it is commonly observed that the shape dynamics of mammalian cells can undergo large random fluctuations, theoretical models aiming at capturing cell mechanics often focus on the deterministic part of the motion. In this paper, we…

Biological Physics · Physics 2021-04-07 Vikram Deshpande , Antonio DeSimone , Robert McMeeking , Pierre Recho

This paper presents a distributed voltage regulation method based on multi-agent system control and network self-organization for a large distribution network. The network autonomously organizes itself into small subnetworks through the…

Systems and Control · Electrical Eng. & Systems 2022-02-02 Badr Al Faiya , Dimitrios Athanasiadis , Minjiang Chen , Stephen McArthur , Ivana Kockar , Haowei Lu , Francisco de Leon

The onset of life is often framed around membrane bound compartments and encoded metabolism, leaving unresolved how spatial organization arose before stable boundaries. In this context, environmental gradients are usually treated as…

Other Quantitative Biology · Quantitative Biology 2026-04-23 Arturo Tozzi

In many biological systems localized mechanical information is transmitted by mechanically neutral chemical signals. Typical examples include contraction waves in acto-myosin cortex at cellular scale and peristaltic waves at tissue level.…

Soft Condensed Matter · Physics 2025-11-25 Lev Truskinovsky , Giuseppe Zurlo

We consider self-organization and memory formation in a mesoscopic model of an amorphous solid subject to a random shear strain protocol confined to a strain range $\pm \varepsilon_{\rm max}$. We develop proper read-out protocols to show…

Soft Condensed Matter · Physics 2025-06-03 Muhittin Mungan , Dheeraj Kumar , Sylvain Patinet , Damien Vandembroucq

In this paper, we pose a hypothesis that the structure of communities in complex networks may result from their latent fractal properties. This hypothesis is based not only on the general observation that many real networks have multilevel…

Physics and Society · Physics 2023-09-21 Mateusz Samsel , Kordian Makulski , Michał Łepek , Agata Fronczak , Piotr Fronczak

Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often…

Physics and Society · Physics 2016-02-23 Christos Nicolaides , Ruben Juanes , Luis Cueto-Felgueroso

The spontaneous formation and subsequent growth, dissolution, merger and competition of social groups bears similarities to physical phase transitions in metastable finite systems. We examine three different scenarios, percolation, spinodal…

Physics and Society · Physics 2022-09-22 Frank Schweitzer , Georges Andres

Self-assembly processes in biological and synthetic biomolecular systems are often governed by the spatial separation of biochemical processes. While previous work has focused on optimizing self-assembly through fine-tuned reaction…

Biological Physics · Physics 2026-02-17 Severin Angerpointner , Richard Swiderski , Erwin Frey

We show that finite-size, disordered molecular networks can mediate highly efficient, coherent excitation transfer which is robust against ambient dephasing and associated with strong multi-site entanglement. Such optimal, random molecular…

A stochastic walker model is proposed to describe the chemotactic guidance of growth cones, i.e. the tips of developing neurites. The model accounts for the influence of both attractive and repulsive chemical cues, which are emitted by the…

Analysis of PDEs · Mathematics 2025-11-04 Noah Geltner , Ansgar Jüngel

How patterns and structures undergo symmetry breaking and self-organize within biological systems from initially homogeneous states is a key issue for biological development. The activator-inhibitor (AI) mechanism, derived from…

Biological Physics · Physics 2022-11-01 Xiaoliang Wang , Andrew Harrison

Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

Using simulation and theory we study the dynamics of a colloidal suspension in two dimensions subject to a time-delayed repulsive feedback that depends on the positions of the colloidal particles. The colloidal particles experience an…

Soft Condensed Matter · Physics 2019-09-06 Sonja Tarama , Stefan U. Egelhaaf , Hartmut Löwen