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Automated diagnosis based on color fundus photography is essential for large-scale glaucoma screening. However, existing deep learning models are typically data-driven and lack explicit integration of retinal anatomical knowledge, which…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Yuzhuo Zhou , Chi Liu , Sheng Shen , Zongyuan Ge , Fengshi Jing , Shiran Zhang , Yu Jiang , Anli Wang , Wenjian Liu , Feilong Yang , Tianqing Zhu , Xiaotong Han

Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement…

Image and Video Processing · Electrical Eng. & Systems 2023-08-02 Lehan Wang , Weihang Dai , Mei Jin , Chubin Ou , Xiaomeng Li

Objectives: To evaluate the performance of an Artificial Intelligence (AI) system (Pegasus, Visulytix Ltd., UK), at the detection of Diabetic Retinopathy (DR) from images captured by a handheld portable fundus camera. Methods: A cohort of…

Image and Video Processing · Electrical Eng. & Systems 2019-08-20 T W Rogers , J Gonzalez-Bueno , R Garcia Franco , E Lopez Star , D Méndez Marín , J Vassallo , V C Lansingh , S Trikha , N Jaccard

WHO has declared that more than 2.2 billion people worldwide are suffering from visual disorders, such as media haze, glaucoma, and drusen. At least 1 billion of these cases could have been either prevented or successfully treated, yet they…

Image and Video Processing · Electrical Eng. & Systems 2024-05-30 Yavuz Selim Inan

The purpose of this study is to evaluate the performance of the OphtAI system for the automatic detection of referable diabetic retinopathy (DR) and the automatic assessment of DR severity using color fundus photography. OphtAI relies on…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Gwenolé Quellec , Mathieu Lamard , Bruno Lay , Alexandre Le Guilcher , Ali Erginay , Béatrice Cochener , Pascale Massin

Automatic diabetic retinopathy (DR) grading based on fundus photography has been widely explored to benefit the routine screening and early treatment. Existing researches generally focus on single-field fundus images, which have limited…

Computer Vision and Pattern Recognition · Computer Science 2022-12-02 Junlin Hou , Jilan Xu , Fan Xiao , Rui-Wei Zhao , Yuejie Zhang , Haidong Zou , Lina Lu , Wenwen Xue , Rui Feng

Glaucoma is the leading cause of preventable, irreversible blindness world-wide. The disease can remain asymptomatic until severe, and an estimated 50%-90% of people with glaucoma remain undiagnosed. Glaucoma screening is recommended for…

Automatic evaluation of the retinal fundus image is emerging as one of the most important tools for early detection and treatment of progressive eye diseases like Glaucoma. Glaucoma results to a progressive degeneration of vision and is…

Image and Video Processing · Electrical Eng. & Systems 2021-12-13 Sneha Dasgupta , Rishav Mukherjee , Kaushik Dutta , Anindya Sen

Recent advancements in ophthalmology foundation models such as RetFound have demonstrated remarkable diagnostic capabilities but require massive datasets for effective pre-training, creating significant barriers for development and…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 Qingshan Hou , Meng Wang , Peng Cao , Zou Ke , Xiaoli Liu , Huazhu Fu , Osmar R. Zaiane

Access to obstetric ultrasound is often limited in low-resource settings, particularly in rural areas of low- and middle-income countries. This work proposes a human-in-the-loop artificial intelligence (AI) system designed to assist…

Human-Computer Interaction · Computer Science 2025-10-03 Juan Barrientos , Michaelle Pérez , Douglas González , Favio Reyna , Julio Fajardo , Andrea Lara

Diabetic Retinopathy (DR) is a major cause of vision impairment worldwide. However, manual diagnosis is often time-consuming and prone to errors, leading to delays in screening. This paper presents a lightweight automated deep learning…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Aadi Joshi , Manav S. Sharma , Vijay Uttam Rathod , Ashlesha Sawant , Prajakta Musale , Asmita B. Kalamkar

Artificial Intelligence (AI) is necessary to address the large and growing deficit in retina and healthcare access globally. And mobile AI diagnostic platforms running in the Cloud may effectively and efficiently distribute such AI…

Retinal disease diagnosis is critical in preventing vision loss and reducing socioeconomic burdens. Globally, over 2.2 billion people are affected by some form of vision impairment, resulting in annual productivity losses estimated at $411…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Youssef Sabiri , Walid Houmaidi , Amine Abouaomar

Objectives: To evaluate the performance of a deep learning based Artificial Intelligence (AI) software for detection of glaucoma from stereoscopic optic disc photographs, and to compare this performance to the performance of a large cohort…

Computer Vision and Pattern Recognition · Computer Science 2019-06-05 Thomas W. Rogers , Nicolas Jaccard , Francis Carbonaro , Hans G. Lemij , Koenraad A. Vermeer , Nicolaas J. Reus , Sameer Trikha

In this paper, a method is presented for superimposition (i.e. registration) of eye fundus images from persons with diabetes screened over many years for diabetic retinopathy. The method is fully automatic and robust to camera changes and…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Guillaume Noyel , Rebecca Thomas , Gavin Bhakta , Andrew Crowder , David Owens , Peter Boyle

The advent of foundation models has heralded a new era in medical artificial intelligence (AI), enabling the extraction of generalizable representations from large-scale unlabeled datasets. However, current ophthalmic AI paradigms are…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Tienyu Chang , Zhen Chen , Renjie Liang , Jinyu Ding , Jie Xu , Sunu Mathew , Amir Reza Hajrasouliha , Andrew J. Saykin , Ruogu Fang , Yu Huang , Jiang Bian , Qingyu Chen

Inability to express the confidence level and detect unseen classes has limited the clinical implementation of artificial intelligence in the real-world. We developed a foundation model with uncertainty estimation (FMUE) to detect 11…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Yuanyuan Peng , Aidi Lin , Meng Wang , Tian Lin , Ke Zou , Yinglin Cheng , Tingkun Shi , Xulong Liao , Lixia Feng , Zhen Liang , Xinjian Chen , Huazhu Fu , Haoyu Chen

Traditional biomedical artificial intelligence (AI) models, designed for specific tasks or modalities, often exhibit limited flexibility in real-world deployment and struggle to utilize holistic information. Generalist AI holds the…

Papilledema is an ophthalmic neurologic disorder in which increased intracranial pressure leads to swelling of the optic nerves. Undiagnosed papilledema in children may lead to blindness and may be a sign of life-threatening conditions,…

Image and Video Processing · Electrical Eng. & Systems 2022-07-12 Kleanthis Avramidis , Mohammad Rostami , Melinda Chang , Shrikanth Narayanan

Automated optic disc (OD) and optic cup (OC) segmentation in fundus images is relevant to efficiently measure the vertical cup-to-disc ratio (vCDR), a biomarker commonly used in ophthalmology to determine the degree of glaucomatous optic…