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Spatial transcriptomics is an emerging technology that aligns histopathology images with spatially resolved gene expression profiling. It holds the potential for understanding many diseases but faces significant bottlenecks such as…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Gabriel Mejia , Paula Cárdenas , Daniela Ruiz , Angela Castillo , Pablo Arbeláez

Despite the prevalence and significance of tabular data across numerous industries and fields, it has been relatively underexplored in the realm of deep learning. Even today, neural networks are often overshadowed by techniques such as…

Machine Learning · Computer Science 2024-07-19 Andreas Voskou , Charalambos Christoforou , Sotirios Chatzis

This paper discusses the role of Transfer Learning (TL) and transformers in cancer detection based on image analysis. With the enormous evolution of cancer patients, the identification of cancer cells in a patient's body has emerged as a…

Image and Video Processing · Electrical Eng. & Systems 2023-11-17 Amine Bechar , Youssef Elmir , Rafik Medjoudj , Yassine Himeur , Abbes Amira

Deep learning models have demonstrated remarkable success in multi-organ segmentation but typically require large-scale datasets with all organs of interest annotated. However, medical image datasets are often low in sample size and only…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Han Liu , Zhoubing Xu , Riqiang Gao , Hao Li , Jianing Wang , Guillaume Chabin , Ipek Oguz , Sasa Grbic

Transfer learning can address the learning tasks of unlabeled data in the target domain by leveraging plenty of labeled data from a different but related source domain. A core issue in transfer learning is to learn a shared feature space in…

Machine Learning · Computer Science 2019-01-10 Peng Xu , Zhaohong Deng , Jun Wang , Qun Zhang , Shitong Wang

The advancement of Spatial Transcriptomics (ST) has facilitated the spatially-aware profiling of gene expressions based on histopathology images. Although ST data offers valuable insights into the micro-environment of tumors, its…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Hongyi Wang , Xiuju Du , Jing Liu , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin

Survival prognosis is crucial for medical informatics. Practitioners often confront small-sized clinical data, especially cancer patient cases, which can be insufficient to induce useful patterns for survival predictions. This study deals…

Machine Learning · Computer Science 2025-01-23 Yonghao Zhao , Changtao Li , Chi Shu , Qingbin Wu , Hong Li , Chuan Xu , Tianrui Li , Ziqiang Wang , Zhipeng Luo , Yazhou He

Transfer learning is beneficial for survival analysis, especially when the target study has a limited number of events. However, existing transfer learning methods rely on the restrictive assumption that the target and source studies share…

Methodology · Statistics 2026-03-13 Yu Gu , Donglin Zeng , D. Y. Lin

This paper delves into the challenges and advancements in the field of medical image segmentation, particularly focusing on breast cancer diagnosis. The authors propose a novel Transformer-based segmentation model that addresses the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-20 Weijie He , Runyuan Bao , Yiru Cang , Jianjun Wei , Yang Zhang , Jiacheng Hu

Through sequence-based classification, this paper tries to accurately predict the DNA binding sites of transcription factors (TFs) in an unannotated cellular context. Related methods in the literature fail to perform such predictions…

Machine Learning · Computer Science 2016-11-17 Ritambhara Singh , Jack Lanchantin , Gabriel Robins , Yanjun Qi

This work proposes a classification approach for breast cancer histopathologic images (HI) that uses transfer learning to extract features from HI using an Inception-v3 CNN pre-trained with ImageNet dataset. We also use transfer learning on…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Jonathan de Matos , Alceu de S. Britto , Luiz E. S. Oliveira , Alessandro L. Koerich

Spatially resolved transcriptomics is a fast-developing set of technologies that enables the measurement of localized gene expression across spatial locations in a sample. Detecting spatially varying genes is critical for analyzing such…

Applications · Statistics 2026-04-22 Pritam Dey , Rajarshi Guhaniyogi , Yang Ni , Bani K. Mallick

Spatial transcriptomics has revolutionized tissue analysis by simultaneously mapping gene expression, spatial topography, and histological context across consecutive tissue sections, enabling systematic investigation of spatial…

Applications · Statistics 2025-10-24 Meng Zhou , Shuangge Ma , Mengyun Wu

Spatial transcriptomics (ST) reveals spatial heterogeneity of gene expression, yet its resolution is limited by current platforms. Recent methods enhance resolution via H&E-stained histology, but three major challenges persist: (1)…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Xuepeng Liu , Zheng Jiang , Pinan Zhu , Hanyu Liu , Chao Li

The advent of next-generation sequencing-based spatially resolved transcriptomics (SRT) techniques has reshaped genomic studies by enabling high-throughput gene expression profiling while preserving spatial and morphological context.…

Applications · Statistics 2025-02-20 Bencong Zhu , Alberto Cassese , Marina Vannucci , Michele Guindani , Qiwei Li

Transfer learning is a standard technique to improve performance on tasks with limited data. However, for medical imaging, the value of transfer learning is less clear. This is likely due to the large domain mismatch between the usual…

Breast cancer is one of the leading causes of mortality in women. Early detection and treatment are imperative for improving survival rates, which have steadily increased in recent years as a result of more sophisticated…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Sulaiman Vesal , Nishant Ravikumar , AmirAbbas Davari , Stephan Ellmann , Andreas Maier

Early diagnosis of interstitial lung diseases is crucial for their treatment, but even experienced physicians find it difficult, as their clinical manifestations are similar. In order to assist with the diagnosis, computer-aided diagnosis…

Computer Vision and Pattern Recognition · Computer Science 2016-12-13 Stergios Christodoulidis , Marios Anthimopoulos , Lukas Ebner , Andreas Christe , Stavroula Mougiakakou

Semi-supervised learning (SSL) has achieved significant progress in medical image segmentation (SSMIS) through effective utilization of limited labeled data. While current SSL methods for medical images predominantly rely on consistency…

Image and Video Processing · Electrical Eng. & Systems 2025-05-22 Mengzhu Wang , Jiao Li , Shanshan Wang , Long Lan , Huibin Tan , Liang Yang , Guoli Yang

Deep neural networks have introduced significant advancements in the field of machine learning-based analysis of digital pathology images including prostate tissue images. With the help of transfer learning, classification and segmentation…