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Spatially resolved transcriptomics brings exciting breakthroughs to single-cell analysis by providing physical locations along with gene expression. However, as a cost of the extremely high spatial resolution, the cellular level spatial…

Genomics · Quantitative Biology 2024-02-19 Hongzhi Wen , Wenzhuo Tang , Wei Jin , Jiayuan Ding , Renming Liu , Xinnan Dai , Feng Shi , Lulu Shang , Hui Liu , Yuying Xie

Hand gesture-based Sign Language Recognition (SLR) serves as a crucial communication bridge between deaf and non-deaf individuals. While Graph Convolutional Networks (GCNs) are common, they are limited by their reliance on fixed skeletal…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Koki Hirooka , Abu Saleh Musa Miah , Tatsuya Murakami , Md. Al Mehedi Hasan , Yong Seok Hwang , Jungpil Shin

Modern data-driven applications increasingly rely on large, heterogeneous datasets collected across multiple sites. Differences in data availability, feature representation, and underlying populations often induce structured missingness,…

Methodology · Statistics 2026-02-24 Mengyan Li , Xiaoou Li , Kenneth D Mandl , Tianxi Cai

Clinical and biomedical research in low-resource settings often faces significant challenges due to the need for high-quality data with sufficient sample sizes to construct effective models. These constraints hinder robust model training…

Spatial transcriptomics measures the expression of thousands of genes in a tissue sample while preserving its spatial structure. This class of technologies has enabled the investigation of the spatial variation of gene expressions and their…

Methodology · Statistics 2025-10-23 Andrea Sottosanti , Davide Risso , Francesco Denti

Spatial transcriptomics (ST) technologies can be used to align transcriptomes with histopathological morphology, presenting exciting new opportunities for biomolecular discovery. Using ST data, we construct a novel framework, GeneFlow, to…

Quantitative Methods · Quantitative Biology 2025-11-04 Mengbo Wang , Shourya Verma , Aditya Malusare , Luopin Wang , Yiyang Lu , Vaneet Aggarwal , Mario Sola , Ananth Grama , Nadia Atallah Lanman

Spatial Transcriptomics (ST) provides spatially-resolved gene expression, offering crucial insights into tissue architecture and complex diseases. However, its prohibitive cost limits widespread adoption, leading to significant attention on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Taejin Jeong , Joohyeok Kim , Jinyeong Kim , Chanyoung Kim , Seong Jae Hwang

Unpaired medical image synthesis aims to provide complementary information for an accurate clinical diagnostics, and address challenges in obtaining aligned multi-modal medical scans. Transformer-based models excel in imaging translation…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Vu Minh Hieu Phan , Yutong Xie , Bowen Zhang , Yuankai Qi , Zhibin Liao , Antonios Perperidis , Son Lam Phung , Johan W. Verjans , Minh-Son To

Spatial transcriptomic (ST) clustering employs spatial and transcription information to group spots spatially coherent and transcriptionally similar together into the same spatial domain. Graph convolution network (GCN) and graph attention…

Quantitative Methods · Quantitative Biology 2023-10-24 Chen Zhang , Junhui Gao , Lingxin Kong , Guangshuo cao , Xiangyu Guo , Wei Liu

Spatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a…

Genomics · Quantitative Biology 2024-03-19 Xiaoyu Li , Wenwen Min , Shunfang Wang , Changmiao Wang , Taosheng Xu

In this paper, we introduce QuST-LLM, an innovative extension of QuPath that utilizes the capabilities of large language models (LLMs) to analyze and interpret spatial transcriptomics (ST) data. In addition to simplifying the intricate and…

Genomics · Quantitative Biology 2024-07-03 Chao Hui Huang

Breast cancer screening, primarily conducted through mammography, is often supplemented with ultrasound for women with dense breast tissue. However, existing deep learning models analyze each modality independently, missing opportunities to…

Image and Video Processing · Electrical Eng. & Systems 2023-11-16 Yiqiu Shen , Jungkyu Park , Frank Yeung , Eliana Goldberg , Laura Heacock , Farah Shamout , Krzysztof J. Geras

Identifying new disease-related patterns in medical imaging data with the help of machine learning enlarges the vocabulary of recognizable findings. This supports diagnostic and prognostic assessment. However, image appearance varies not…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Jeanny Pan , Philipp Seeböck , Christoph Fürböck , Svitlana Pochepnia , Jennifer Straub , Lucian Beer , Helmut Prosch , Georg Langs

Self-supervised learning has proven to be an effective way to learn representations in domains where annotated labels are scarce, such as medical imaging. A widely adopted framework for this purpose is contrastive learning and it has been…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hugo Figueiras , Helena Aidos , Nuno Cruz Garcia

Breast cancer is a major global health issue that affects millions of women worldwide. Classification of breast cancer as early and accurately as possible is crucial for effective treatment and enhanced patient outcomes. Deep transfer…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Prudence Djagba , J. K. Buwa Mbouobda

In activity recognition, it is often expensive and time-consuming to acquire sufficient activity labels. To solve this problem, transfer learning leverages the labeled samples from the source domain to annotate the target domain which has…

Computer Vision and Pattern Recognition · Computer Science 2018-01-04 Jindong Wang , Yiqiang Chen , Lisha Hu , Xiaohui Peng , Philip S. Yu

Latent space model plays a crucial role in network analysis, and accurate estimation of latent variables is essential for downstream tasks such as link prediction. However, the large number of parameters to be estimated presents a…

Methodology · Statistics 2025-09-22 Kuangnan Fang , Ruixuan Qin , Xinyan Fan

Spatial transcriptomics (ST) enables mapping gene expression with spatial context but is severely affected by high sparsity and technical noise, which conceals true biological signals and hinders downstream analyses. To address these…

Machine Learning · Computer Science 2026-03-10 Sayeem Bin Zaman , Fahim Hafiz , Riasat Azim

Cancer is one of the deadliest diseases worldwide. Accurate diagnosis and classification of cancer subtypes are indispensable for effective clinical treatment. Promising results on automatic cancer subtyping systems have been published…

Machine Learning · Computer Science 2022-04-06 Ziwei Yang , Lingwei Zhu , Zheng Chen , Ming Huang , Naoaki Ono , MD Altaf-Ul-Amin , Shigehiko Kanaya

Accurate segmentation of brain tumors from 3D multimodal MRI is vital for diagnosis and treatment planning across diverse brain tumors. This paper addresses the challenges posed by the BraTS 2023, presenting a unified transfer learning…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Ramy A. Zeineldin , Franziska Mathis-Ullrich
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