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Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at…

Background: Dose calculation and optimization algorithms in proton therapy treatment planning often have high computational requirements regarding time and memory. This can hinder the implementation of efficient workflows in clinics and…

Medical Physics · Physics 2023-04-18 D. Pross , S. Wuyckens , S. Deffet , E. Sterpin , J. A. Lee , K. Souris

We report about the methods used in, and the performance of, the new fast and light-weight linear beam transport program MinT. MinT provides, beyond the usual linear ion optics, methods to compute the effects of beam degradation, multiple…

Accelerator Physics · Physics 2023-07-31 C. Baumgarten

Physics-based Ising machines (IM) have been developed as dedicated processors for solving hard combinatorial optimization problems with higher speed and better energy efficiency. Generally, such systems employ local search heuristics to…

Disordered Systems and Neural Networks · Physics 2024-10-22 Dmitrii Dobrynin , Adrien Renaudineau , Mohammad Hizzani , Dmitri Strukov , Masoud Mohseni , John Paul Strachan

In the context of quantum secure scenarios, existing research on mobile edge devices and intelligent computing and edge (ICE) systems based on the Non-Orthogonal Multiple Access (NOMA) communication model have overlooked the energy…

Information Theory · Computer Science 2026-04-30 Yongtao Yao , Wenjing Xiao , Miaojiang Chen , Anfeng Liu , Zhiquan Liu , Min Chen , Ahmed Farouk , H. Herbert Song

The modern workflow for radiation therapy treatment planning involves mathematical optimization to determine optimal treatment machine parameters for each patient case. The optimization problems can be computationally expensive, requiring…

Mathematical Software · Computer Science 2023-05-30 Felix Liu , Måns I. Andersson , Albin Fredriksson , Stefano Markidis

Dynamic voltage and frequency scaling proves to be an efficient way of reducing energy consumption of servers. Energy savings are typically achieved by setting a well-chosen frequency during some program phases. However, determining…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-02-26 Amina Guermouche , Nicolas Triquenaux , Benoit Pradelle , William Jalby

The interior-point method (IPM) has become the workhorse method for nonlinear programming. The performance of IPM is directly related to the linear solver employed to factorize the Karush--Kuhn--Tucker (KKT) system at each iteration of the…

Optimization and Control · Mathematics 2022-03-23 François Pacaud , Sungho Shin , Michel Schanen , Daniel Adrian Maldonado , Mihai Anitescu

Autonomous vehicle (AV) motion planning problems often involve non-convex constraints, which present a major barrier to applying model predictive control (MPC) in real time on embedded hardware. This paper presents an approach for…

Systems and Control · Electrical Eng. & Systems 2026-03-03 Joshua A. Robbins , Jacob A. Siefert , Sean Brennan , Herschel C. Pangborn

Purpose: A promising approach to enable FLASH conformal proton therapy is to passively degrade a single energy layer using a patient-specific range modulator. We propose an innovative method to directly optimize the geometrical…

Medical Physics · Physics 2023-03-16 Sylvain Deffet , Kevin Souris , Edmond Sterpin

Influence diagrams represent decision-making problems with interdependencies between random events, decisions, and consequences. Traditionally, they have been solved using algorithms that determine the expected utility-maximizing decision…

Optimization and Control · Mathematics 2026-01-14 Topias Terho , Fabricio Oliveira , Ahti Salo , Pedro Munari

Solving optimization problems is challenging for existing digital computers and even for future quantum hardware. The practical importance of diverse problems, from healthcare to financial optimization, has driven the emergence of…

In experimental High-Energy Physics, unfolding refers to the problem of estimating the underlying distribution of a physical observable from detector-level data, in the presence of statistical fluctuations and systematic uncertainties.…

Quantum Physics · Physics 2026-05-13 Simone Gasperini , Gianluca Bianco , Marco Lorusso , Carla Rieger , Michele Grossi

Low-thrust electric propulsion missions are often designed under simplifying assumptions such as constant thrust or fixed specific impulse, neglecting the strong coupling between trajectory dynamics, spacecraft power availability, and…

Systems and Control · Electrical Eng. & Systems 2026-03-05 Yacob Medhin , Tushar Sial , Simone Servadio

We propose an energy-optimized invariant energy quadratization method to solve the gradient flow models in this paper, which requires only one linear energy-optimized step to correct the auxiliary variables on each time step. In addition to…

Numerical Analysis · Mathematics 2024-04-03 Xiaoqing Meng , Aijie Cheng , Zhengguang Liu

This paper presents key enhancements to our previous work~\cite{naghmouchi2024mixed} on a hybrid Benders decomposition (HBD) framework for solving mixed integer linear programs (MILPs). In our approach, the master problem is reformulated as…

Quantum Physics · Physics 2026-01-23 Anna Joliot , M. Yassine Naghmouchi , Wesley Coelho

Purpose: This study explored the feasibility of a streamlined pin-shaped ridge filter (pin-RF) design for single-energy proton FLASH planning. Methods: An inverse planning framework integrated within a TPS was established for FLASH…

Edge computing is a promising technology that offers a superior user experience and enables various innovative Internet of Things applications. In this paper, we present a mixed-integer linear programming (MILP) model for optimal edge…

Quantum Physics · Physics 2023-06-05 Duong The Do , Ni Trieu , Duong Tung Nguyen

The TOP-IMPLART project consists of the design and implementation of a linear proton accelerator, its control and monitoring systems for the treatment of superficial and semi-deep tumors. The energy of 150 MeV (corresponding to a…

Proton pencil beam scanning (PBS) treatment planning for head & neck (H&N) cancers involves numerous conflicting objectives, requiring iterative objective parameter adjustments to balance multiple clinical goals. We propose a…

Artificial Intelligence · Computer Science 2025-09-16 Qingqing Wang , Liqiang Xiao , Chang Chang
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