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Inspired by the success of generative pretraining in natural language, we ask whether the same principles can yield strong self-supervised visual learners. Instead of training models to output features for downstream use, we train them to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Sihan Xu , Ziqiao Ma , Wenhao Chai , Xuweiyi Chen , Weiyang Jin , Joyce Chai , Saining Xie , Stella X. Yu

Parameter-efficient fine-tuning (PEFT) has shown its effectiveness in adapting the pre-trained language models to downstream tasks while only updating a small number of parameters. Despite the success, most existing methods independently…

Computation and Language · Computer Science 2023-11-14 Hao Zhao , Jie Fu , Zhaofeng He

Foundational vision transformer models have shown impressive few shot performance on many vision tasks. This research presents a novel investigation into the application of parameter efficient fine-tuning methods within an active learning…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Athmanarayanan Lakshmi Narayanan , Ranganath Krishnan , Amrutha Machireddy , Mahesh Subedar

Humans excel in analogical learning and knowledge transfer and, more importantly, possess a unique understanding of identifying appropriate sources of knowledge. From a model's perspective, this presents an interesting challenge. If models…

Machine Learning · Computer Science 2026-01-12 Xinhao Zhang , Jinghan Zhang , Fengran Mo , Dongjie Wang , Yanjie Fu , Kunpeng Liu

Knowledge distillation (KD) has been extensively employed to transfer the knowledge from a large teacher model to the smaller students, where the parameters of the teacher are fixed (or partially) during training. Recent studies show that…

Machine Learning · Computer Science 2022-06-01 Jun Rao , Xv Meng , Liang Ding , Shuhan Qi , Dacheng Tao

Understanding disease progression at the molecular pathway level usually requires capturing both structural dependencies between pathways and the temporal dynamics of disease evolution. In this work, we solve the former challenge by…

Machine Learning · Computer Science 2025-02-11 Dai Shi , Kuan Yan , Lequan Lin , Yue Zeng , Ting Zhang , Dmytro Matsypura , Mark C. Gillies , Ling Zhu , Junbin Gao

Pretrained Foundation Models (PFMs) have transformed numerous applications by enabling efficient adaptation to customized tasks. Parameter-Efficient Fine-Tuning (PEFT) has emerged as a resource-efficient alternative to full fine-tuning,…

Machine Learning · Computer Science 2025-06-16 Baoquan Zhang , Guangning Xu , Michael. K. Ng

Understanding transcription factor dynamics is crucial for unraveling the regulatory mechanisms of gene expression that underpin cellular function and development. Measurements of transcription factor subcellular movements are essential for…

Quantitative Methods · Quantitative Biology 2025-03-20 Sharva V. Hiremath , Etika Goyal , Gregory T. Reeves , Cranos M. Williams

Identifying pills given their captured images under various conditions and backgrounds has been becoming more and more essential. Several efforts have been devoted to utilizing the deep learning-based approach to tackle the pill recognition…

Computer Vision and Pattern Recognition · Computer Science 2022-08-10 Anh Duy Nguyen , Thuy Dung Nguyen , Huy Hieu Pham , Thanh Hung Nguyen , Phi Le Nguyen

We introduce a self-supervised speech pre-training method called TERA, which stands for Transformer Encoder Representations from Alteration. Recent approaches often learn by using a single auxiliary task like contrastive prediction,…

Audio and Speech Processing · Electrical Eng. & Systems 2021-08-05 Andy T. Liu , Shang-Wen Li , Hung-yi Lee

Neural networks are one tool for approximating non-linear differential equations used in scientific computing tasks such as surrogate modeling, real-time predictions, and optimal control. PDE foundation models utilize neural networks to…

Machine Learning · Computer Science 2025-02-11 Elisa Negrini , Yuxuan Liu , Liu Yang , Stanley J. Osher , Hayden Schaeffer

Reverse-phase protein array (RPPA) analysis is a powerful, relatively new platform that allows for high-throughput, quantitative analysis of protein networks. One of the challenges that currently limit the potential of this technology is…

The emergence of pathology foundation models has revolutionized computational histopathology, enabling highly accurate, generalized whole-slide image analysis for improved cancer diagnosis, and prognosis assessment. While these models show…

Advances in foundation modeling have reshaped computational pathology. However, the increasing number of available models and lack of standardized benchmarks make it increasingly complex to assess their strengths, limitations, and potential…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Andrew Zhang , Guillaume Jaume , Anurag Vaidya , Tong Ding , Faisal Mahmood

The success of precision medicine requires computational models that can effectively process and interpret diverse physiological signals across heterogeneous patient populations. While foundation models have demonstrated remarkable transfer…

Machine Learning · Computer Science 2024-12-05 Matthias Christenson , Cove Geary , Brian Locke , Pranav Koirala , Warren Woodrich Pettine

Joint-Embedding Predictive Architectures (JEPAs) have recently emerged as a novel and powerful technique for self-supervised representation learning. They aim to learn an energy-based model by predicting the latent representation of a…

Machine Learning · Computer Science 2025-01-22 Geri Skenderi , Hang Li , Jiliang Tang , Marco Cristani

Recent advancements in multimodal pre-training models have significantly advanced computational pathology. However, current approaches predominantly rely on visual-language models, which may impose limitations from a molecular perspective…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Minghao Han , Dingkang Yang , Jiabei Cheng , Xukun Zhang , Linhao Qu , Zizhi Chen , Lihua Zhang

Cells regulate themselves via dizzyingly complex biochemical processes called signaling pathways. These are usually depicted as a network, where nodes represent proteins and edges indicate their influence on each other. In order to…

Molecular Networks · Quantitative Biology 2021-01-13 David Merrell , Anthony Gitter

Electroencephalography (EEG) signals provide critical insights for applications in disease diagnosis and healthcare. However, the scarcity of labeled EEG data poses a significant challenge. Foundation models offer a promising solution by…

Machine Learning · Computer Science 2025-02-25 Limin Wang , Toyotaro Suzumura , Hiroki Kanezashi

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Tengyue Zhang , Ruiwen Ding , Luoting Zhuang , Yuxiao Wu , Erika F. Rodriguez , William Hsu