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In this work, we develop patient-specific cardiocirculatory models with the aim of building Digital Twins for hypertension. In particular, in our pathophysiology-based framework, we consider both 0D cardiocirculatory models and a 3D-0D…
There is currently limited understanding of the role played by haemodynamic forces on the processes governing vascular development. One of many obstacles to be overcome is being able to measure those forces, at the required resolution…
Light-matter interfaces enable the generation of entangled states of light and matter which can be exploited to steer the quantum state of matter through measurement of light and feedback. Here we consider continuous-time, interferometric…
Voltage-sensitive fluorescence imaging is widely used to image action potential waves in the heart. However, while the electrical waves trigger mechanical contraction, imaging needs to be performed with pharmacologically…
The HeartBert model is introduced with three primary objectives: reducing the need for labeled data, minimizing computational resources, and simultaneously improving performance in machine learning systems that analyze Electrocardiogram…
Morphology of cardiovascular tissue is influenced by the unsteady behavior of the blood flow and vice versa. Therefore, the pathogenesis of several cardiovascular diseases is directly affected by the blood-flow dynamics. Understanding flow…
A new approach is developed to integrate numerically the equations of motion for systems of interacting rigid polyatomic molecules. With the aid of a leapfrog framework, we directly involve principal angular velocities into the integration,…
Understanding and simulating how a quantum system interacts and exchanges information or energy with its surroundings is a ubiquitous problem, one which must be carefully addressed in order to establish a coherent framework to describe the…
The simulation of blood flow and pressure in arteries requires outflow boundary conditions that incorporate models of downstream domains. We previously described a coupled multidomain method to couple analytical models of the downstream…
This review article discusses current technological advances in biomedical devices,emphasizing cardiovascular and ophthalmic application diagnostic,monitoring, and prosthetic instruments and systems. The scope encompasses various aspects,…
One-dimensional (1D) blood flow simulations are extensively used in cardiovascular research due to their computational efficiency and effectiveness in analyzing pulse wave dynamics. Despite their versatility and simplicity, there is a lack…
Understanding the mechanisms of interactions within cells, tissues, and organisms is crucial to driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating biological systems and revealing…
We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration…
Computational fluid dynamics is intensively used to deepen the understanding of aneurysm growth and rupture in the attempt to support physicians during therapy planning. Numerous studies have assumed fully-rigid vessel walls in their…
The visual analysis of retinal data contributes to the understanding of a wide range of eye diseases. For the evaluation of cross-sectional studies, ophthalmologists rely on workflows and toolsets established in their work environment. That…
Cardiovascular diseases are a leading cause of fatalities worldwide, often occurring suddenly with limited time for intervention. Current healthcare monitoring systems for cardiac patients rely heavily on hospitalization, which can be…
This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics…
Understanding the many-body dynamics of isolated quantum systems is one of the central challenges in modern physics. To this end, the direct experimental realization of strongly correlated quantum systems allows one to gain insights into…
Recent \emph{in vivo} experiments have illustrated the importance of understanding the hemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between hemodynamic forces,…
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…