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Universally modeling all typical information extraction tasks (UIE) with one generative language model (GLM) has revealed great potential by the latest study, where various IE predictions are unified into a linearized hierarchical…

Computation and Language · Computer Science 2023-04-14 Hao Fei , Shengqiong Wu , Jingye Li , Bobo Li , Fei Li , Libo Qin , Meishan Zhang , Min Zhang , Tat-Seng Chua

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

The nondeterminism of Deep Learning (DL) training algorithms and its influence on the explainability of neural network (NN) models are investigated in this work with the help of image classification examples. To discuss the issue, two…

Machine Learning · Computer Science 2022-03-03 A. -M. Leventi-Peetz , T. Östreich

We investigate molecular mechanisms of resistant or sensitive response of cancer drug combination therapies in an inductive and interpretable manner. Though deep learning algorithms are widely used in the drug synergy prediction problem, it…

Machine Learning · Computer Science 2021-05-18 Zehao Dong , Heming Zhang , Yixin Chen , Fuhai Li

In the rewriting logic framework, equational-based specifications are used to define deterministic functional behavior, abstract data types, and canonical representations of data. These specifications include a (possibly order-sorted)…

Logic in Computer Science · Computer Science 2026-04-22 Mateo Sanabria , Carlos Varela , Camilo Rocha , Nicolas Cardozo

Modern Artificial Intelligence (AI) systems excel at diverse tasks, from image classification to strategy games, even outperforming humans in many of these domains. After making astounding progress in language learning in the recent decade,…

Computation and Language · Computer Science 2022-01-11 Marina Dubova

The current structure-centric paradigm in artificial intelligence (AI)-driven materials discovery, despite delivering thousands of candidate structures, is stalling at a critical barrier: the synthesizability gap. We argue that closing this…

Materials Science · Physics 2026-05-04 Guillaume Lambard

AI policy guidance is predominantly written as prose, which practitioners must first convert into executable rules before frameworks can evaluate or enforce them. This manual step is slow, error-prone, difficult to scale, and often delays…

Artificial Intelligence · Computer Science 2025-12-05 Gautam Varma Datla , Anudeep Vurity , Tejaswani Dash , Tazeem Ahmad , Mohd Adnan , Saima Rafi

The future development of an AI scientist, a tool that is capable of integrating a variety of experimental data and generating testable hypotheses, holds immense potential. So far, bespoke machine learning models have been created to…

Quantitative Methods · Quantitative Biology 2024-03-05 Tyler D. Ross , Ashwin Gopinath

While AI innovation accelerates rapidly, the intellectual process behind breakthroughs -- how researchers identify gaps, synthesize prior work, and generate insights -- remains poorly understood. The lack of structured data on scientific…

Artificial Intelligence · Computer Science 2026-01-09 Jiachen Liu , Maestro Harmon , Zechen Zhang

Structural probes learn a linear transformation to find how dependency trees are embedded in the hidden states of language models. This simple design may not allow for full exploitation of the structure of the encoded information. Hence, to…

Computation and Language · Computer Science 2024-02-27 Avik Pal , Madhura Pawar

Natural language understanding (NLU) of text is a fundamental challenge in AI, and it has received significant attention throughout the history of NLP research. This primary goal has been studied under different tasks, such as Question…

Computation and Language · Computer Science 2019-08-15 Daniel Khashabi

Compositional generalization remains a foundational weakness of modern neural networks, limiting their robustness and applicability in domains requiring out-of-distribution reasoning. A central, yet unverified, assumption in neuro-symbolic…

Artificial Intelligence · Computer Science 2026-04-30 Mahnoor Shahid , Hannes Rothe

Inverse Protein Folding (IPF) is a critical subtask in the field of protein design, aiming to engineer amino acid sequences capable of folding correctly into a specified three-dimensional (3D) conformation. Although substantial progress has…

Computation and Language · Computer Science 2025-05-20 Yanting Li , Jiyue Jiang , Zikang Wang , Ziqian Lin , Dongchen He , Yuheng Shan , Yanruisheng Shao , Jiayi Li , Xiangyu Shi , Jiuming Wang , Yanyu Chen , Yimin Fan , Han Li , Yu Li

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

Institutional decisions -- regulatory compliance, clinical triage, prior authorization appeal -- require a different AI architecture than general-purpose agents provide. Agent frameworks infer authority conversationally, reconstruct…

Artificial Intelligence · Computer Science 2026-04-14 Mamadou Seck

Generative AI is entering research, education, and professional work faster than current governance frameworks can specify how AI-assisted outputs should be judged in learning-intensive settings. The central problem is proxy failure: a…

Artificial Intelligence · Computer Science 2026-04-23 Seine A. Shintani

Despite recent advances in modern machine learning algorithms, the opaqueness of their underlying mechanisms continues to be an obstacle in adoption. To instill confidence and trust in artificial intelligence systems, Explainable Artificial…

Machine Learning · Computer Science 2023-03-06 Zheng Zhang , Liangliang Xu , Levent Yilmaz , Bo Liu

Despite the practical success of Artificial Intelligence (AI), current neural AI algorithms face two significant issues. First, the decisions made by neural architectures are often prone to bias and brittleness. Second, when a chain of…

Artificial Intelligence · Computer Science 2024-10-21 Sushmita Paul , Jinqiang Yu , Jip J. Dekker , Alexey Ignatiev , Peter J. Stuckey

Understanding how the human brain progresses from processing simple linguistic inputs to performing high-level reasoning is a fundamental challenge in neuroscience. While modern large language models (LLMs) are increasingly used to model…

Computation and Language · Computer Science 2026-01-27 Linyang He , Tianjun Zhong , Richard Antonello , Gavin Mischler , Micah Goldblum , Nima Mesgarani