Related papers: A Precision Trial Case Study for Heterogeneous Tre…
Many phase II clinical trials have used survival outcomes as the primary endpoints in recent decades. Suppose the radiotherapy is evaluated in a phase II trial using survival outcomes. In that case, the competing risk issue often arises…
Identifying subgroups, which respond differently to a treatment, both in terms of efficacy and safety, is an important part of drug development. A well-known challenge in exploratory subgroup analyses is the small sample size in the…
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder caused by upper airway blockage, leading to oxygen deprivation and disrupted sleep. Traditional diagnosis using polysomnography (PSG) is expensive, time-consuming,…
Detecting obstructive sleep apnea (OSA) is essential for diagnosing and managing sleep health. Traditionally, this involves clinical settings with hardly accessible processes. We propose that the automated detection of OSA events is…
Patients suffering from obstructive sleep apnea are mainly treated with continuous positive airway pressure (CPAP). Good compliance with this therapy is broadly accepted as more than 4h of CPAP average use nightly. Although it is a highly…
Polysomnography (PSG) is the gold standard for diagnosing sleep obstructive apnea (OSA). It allows monitoring of breathing events throughout the night. The detection of these events is usually done by trained sleep experts. However, this…
In this paper, we develop new methods for estimating average treatment effects in observational studies, focusing on settings with more than two treatment levels under unconfoundedness given pre-treatment variables. We emphasize…
Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) often co-occur as medically unexplained conditions linked to disrupted physiological regulation, including altered sleep. Building on the work of Kishi et al. (2011), who identified…
Pediatric obstructive sleep apnea affects an estimated 1-5% of elementary-school aged children and can lead to other detrimental health problems. Swift diagnosis and treatment are critical to a child's growth and development, but the…
Precision cancer medicine aims to determine the optimal treatment for each patient. In-vitro cancer drug sensitivity screens combined with multi-omics characterization of the cancer cells have become an important tool to achieve this aim.…
Tissue-agnostic trials enroll patients based on their genetic biomarkers, not tumor type, in an attempt to determine if a new drug can successfully treat disease conditions based on biomarkers. The Bayesian hierarchical model (BHM) provides…
Craniofacial profile is one of the anatomical causes of obstructive sleep apnea(OSA). By medical research, cephalometry provides information on patients' skeletal structures and soft tissues. In this work, a novel approach to cephalometric…
Uplift modeling has emerged as a crucial technique for individualized treatment effect estimation, particularly in fields such as marketing and healthcare. Modeling uplift effects in multi-treatment scenarios plays a key role in real-world…
Precision medicine is an approach for disease treatment that defines treatment strategies based on the individual characteristics of the patients. Motivated by an open problem in cancer genomics, we develop a novel model that flexibly…
Precision medicine leverages patient heterogeneity to estimate individualized treatment regimens, formalized, data-driven approaches designed to match patients with optimal treatments. In the presence of competing events, where multiple…
The obstructive sleep apnea-hypopnea (OSAH) syndrome is a very common and frequently undiagnosed sleep disorder. It is characterized by repeated events of partial (hypopnea) or total (apnea) obstruction of the upper airway while sleeping.…
The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…
Obstructive sleep apnea (OSA) is a common sleep disorder and widening the upper airway is often used in clinical practice. However, the success rate of this surgery is limited; the failed surgery would even make the situation worse,…
Due to ethical and economical reasons, sequential single-arm trial designs are used for assessing the therapeutic efficacy of new treatments in phase II trials. Simon's 2-stage design and Lan-DeMets' $\alpha$-spending function method with…
We propose a prognostic stratum matching framework that addresses the deficiencies of Randomized trial data subgroup analysis and transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision…