Related papers: A Precision Trial Case Study for Heterogeneous Tre…

Obstructive Sleep Apnea (OSA) is a breathing disorder during sleep that affects millions of people worldwide. The diagnosis of OSA often occurs through an overnight polysomnogram (PSG) sleep study that generates a massive amount of…

Precision medicine aims to optimize treatment by identifying patient subgroups most likely to benefit from specific interventions. To support this goal, we introduce fkbma, an R package that implements a Bayesian model averaging approach…

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that is associated with increased risks of cardiovascular morbidity and all-cause mortality. While existing diagnostic approaches can roughly classify OSA severity or detect…

Early phase, personalized dose-finding trials for combination therapies seek to identify patient-specific optimal biological dose (OBD) combinations, which are defined as safe dose combinations which maximize therapeutic benefit for a…

Obstructive sleep Apnea (OSA) is a form of sleep disordered breathing characterized by frequent episodes of upper airway collapse during sleep. Pediatric OSA occurs in 1-5% of children and can related to other serious health conditions such…

Cardiovascular diseases (CVDs) are notably prevalent among patients with obstructive sleep apnea (OSA), posing unique challenges in predicting CVD progression due to the intricate interactions of comorbidities. Traditional models typically…

Obstructive sleep apnea (OSA) is one of the most widespread respiratory diseases today. Complete or relative breathing cessations due to upper airway subsidence during sleep is OSA. It has confirmed potential influence on Covid-19…

While machine learning (ML) includes a valuable array of tools for analyzing biomedical data, significant time and expertise is required to assemble effective, rigorous, and unbiased pipelines. Automated ML (AutoML) tools seek to facilitate…

Study Objectives: To evaluate the agreement between the millimeter-wave radar-based device and polysomnography (PSG) in diagnosis of obstructive sleep apnea (OSA) and classification of sleep stage in children. Methods: 281 children, aged 1…

Obstructive sleep apnea (OSA) is a sleep disorder that affects nearly one billion people globally and significantly elevates cardiovascular risk. Traditional diagnosis through polysomnography is resource-intensive and limits widespread…

Paediatric obstructive sleep apnoea (OSA) is clinically significant yet difficult to diagnose, as children poorly tolerate sensor-based polysomnography. Acoustic monitoring provides a non-invasive alternative for home-based OSA screening,…

Obstructive sleep apnea (OSA) is a common sleep disorder caused by abnormal breathing. The severity of OSA can lead to many symptoms such as sudden cardiac death (SCD). Polysomnography (PSG) is a gold standard for OSA diagnosis. It records…

Precision medicine has the potential to tailor treatment decisions to individual patients using machine learning (ML) and artificial intelligence (AI), but it faces significant challenges due to complex biases in clinical observational data…

The study in this paper presents a one-dimensional convolutional neural network (1DCNN) model, designed for the automated detection of obstructive Sleep Apnoea (OSA) captured from single-channel electrocardiogram (ECG) signals. The system…

Obstructive Sleep Apnea Syndrome (OSAS) is the most common sleep-related breathing disorder. It is caused by an increased upper airway resistance during sleep, which determines episodes of partial or complete interruption of airflow. The…

Obstructive Sleep Apnea (OSA) is a highly prevalent but inconspicuous disease that seriously jeopardizes the health of human beings. Polysomnography (PSG), the gold standard of detecting OSA, requires multiple specialized sensors for signal…

Broadening eligibility criteria in cancer trials has been advocated to represent the true patient population more accurately. While the advantages are clear in terms of generalizability and recruitment, novel dose-finding designs are needed…

Obstructive sleep apnea is a serious condition causing a litany of health problems especially in the pediatric population. However, this chronic condition can be treated if diagnosis is possible. The gold standard for diagnosis is an…

Automated sleep stage classification typically employs a single population-agnostic model, disregarding established demographic variations in sleep architecture. Sleep patterns, however, differ substantially across gender, age, and…

Accurately diagnosing sleep disorders is essential for clinical assessments and treatments. Polysomnography (PSG) has long been used for detection of various sleep disorders. In this research, electrocardiography (ECG) and electromayography…