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Positron Emission Tomography (PET) is a medical imaging modality that utilizes positron-emitting isotopes, such as Ga-68 and F-18, for many diagnostic purposes. The positron annihilates with an electron from the surrounding area, creating…

In state-of-the-art Positron Emission Tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via…

Positron Emission Tomography (PET) is a widely-used imaging modality for medical research and clinical diagnosis. Here we demonstrate, through detailed experiments and simulations, an exploration of the benefits of exploiting the quantum…

One of the features of the triplet state of positronium (ortho-Positronium)atoms is its relatively longer lifetime when compared to the singlet states ofpositronium (para-Positronium) atoms. The most probable decay of ortho-Positronium is…

Instrumentation and Detectors · Physics 2020-02-19 Juhi Raj , Kamil Dilski , Eryk Czerwinski

In this study, we explore the use of Co-55 as a radioisotope for multiplexed PET (mPET) by utilizing its emission of a prompt gamma-ray in cascade with a positron during decay. We leverage the prompt-gamma signal to generate triple…

This work reports on a new reconstruction algorithm allowing to reconstruct the decays of ortho-positronium atoms into three photons using the places and times of photons recorded in the detector. The method is based on trilateration and…

We present a nuclear medical imaging technique, employing triple-gamma trajectory intersections from beta^+ - gamma coincidences, able to reach sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of reconstructed…

Medical Physics · Physics 2014-02-18 C. Lang , D. Habs , K. Parodi , P. G. Thirolf

In digital pathology, acquiring all-in-focus images is essential to high-quality imaging and high-efficient clinical workflow. Traditional scanners achieve this by scanning at multiple focal planes of varying depths and then merging them,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Jiangdong Cai , Yan Chen , Zhenrong Shen , Haotian Jiang , Honglin Xiong , Kai Xuan , Lichi Zhang , Qian Wang

Time-of-flight positron emission tomography (TOF-PET) detectors exhibiting multiple coincidence time resolution (CTR) components, such as those induced by the mixing of Cherenkov and scintillation photons, have attracted increasing…

Medical Physics · Physics 2026-05-29 Kibo Ote , Fumio Hashimoto , Yuya Onishi , Ryosuke Ota , Maxime Toussaint , Francis Loignon-Houle

Accurate quantification in positron emission tomography (PET) is essential for accurate diagnostic results and effective treatment tracking. A major issue encountered in PET imaging is attenuation. Attenuation refers to the diminution of…

The potential of photon detectors to achieve precise timing information is of increasing importance in many domains, PET and CT scanners in medical imaging and particle physics detectors, amongst others. The goal to increase by an order of…

Instrumentation and Detectors · Physics 2021-01-11 S. Enoch , A. Gola , P. Lecoq , A. Rivetti

In positron emission tomography (PET) imaging, statistical iterative reconstruction (IR) techniques appear particularly promising since they can provide accurate system model. The system model matrix which describes the relationship between…

PET is a functional imaging technique based on detection of annihilation photons following beta decay producing positrons. In this paper, we present the concept of a new PET system for preclinical applications consisting of a ring of twelve…

Instrumentation and Detectors · Physics 2015-03-19 A. Miceli , P. Amaudruz , F. Benard , D. A. Bryman , L. Kurchaninov , J. P. Martin , A. Muennich , F. Retiere , T. J. Ruth , V. Sossi , A. J. Stoessl

Artificial intelligence (AI) is entering medical imaging, mainly enhancing image reconstruction. Nevertheless, improvements throughout the entire processing, from signal detection to computation, potentially offer significant benefits. This…

Machine Learning · Computer Science 2023-10-27 Stephan Naunheim , Yannick Kuhl , David Schug , Volkmar Schulz , Florian Mueller

With the newly gained interest in the time of flight method for positron emission tomography (TOF-PET), many options for pushing the time resolution to its borders have been investigated. As one of these options the exploitation of the…

Instrumentation and Detectors · Physics 2015-06-16 S. E. Brunner , L. Gruber , J. Marton , K. Suzuki , A. Hirtl

In positron emission tomography (PET), it is indispensable to perform attenuation correction in order to obtain the quantitatively accurate activity map (tracer distribution) in the body. Generally, this is carried out based on the…

Medical Physics · Physics 2025-10-16 Liyang Hu , Chong Chen

Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic…

Positron emission tomography (PET) is the most sensitive biomedical imaging modality for non-invasively detecting and visualizing positron-emitting radiopharmaceuticals within a subject. In PET, measuring the time-of-flight (TOF)…

Instrumentation and Detectors · Physics 2024-10-17 Minseok Yi , Daehee Lee , Alberto Gola , Stefano Merzi , Michele Penna , Jae Sung Lee , Simon R. Cherry , Sun Il Kwon

Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight information is used to improve the image reconstruction process. In Time of Flight PET (TOF-PET), fast detectors are able to measure the difference in the arrival…