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Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Takashi Hato , Pierre C. Dagher , Evan L. Nichols , Cody J. Smith , Kenneth W. Dunn , Scott Howard

Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

Recent denoising algorithms based on the "blind-spot" strategy show impressive blind image denoising performances, without utilizing any external dataset. While the methods excel in recovering highly contaminated images, we observe that…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Chaewon Kim , Jaeho Lee , Jinwoo Shin

Diffusion models have achieved remarkable success in imaging inverse problems owing to their powerful generative capabilities. However, existing approaches typically rely on models trained for specific degradation types, limiting their…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Zhen Wang , Hongyi Liu , Zhihui Wei

Fluorescence lifetime imaging microscopy (FLIM) is an important technique to understand the chemical micro-environment in cells and tissues since it provides additional contrast compared to conventional fluorescence imaging. When two…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Varun Mannam , Xiaotong Yuan , Scott Howard

Unlike single image task, stereo image enhancement can use another view information, and its key stage is how to perform cross-view feature interaction to extract useful information from another view. However, complex noise in low-light…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Minghua Zhao , Xiangdong Qin , Shuangli Du , Xuefei Bai , Jiahao Lyu , Yiguang Liu

Fluoroscopy is critical for real-time X-ray visualization in medical imaging. However, low-dose images are compromised by noise, potentially affecting diagnostic accuracy. Noise reduction is crucial for maintaining image quality, especially…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Sun-Young Jeon , Sen Wang , Adam S. Wang , Garry E. Gold , Jang-Hwan Choi

Endoscopic optical imaging using a single multimode fiber (MMF) has emerged as a promising approach for highly compact, minimally invasive, and high-resolution imaging. Unlike conventional fiber bundles, MMF-based endomicroscopes exploit…

Operando microscopy provides direct insight into the dynamic chemical and physical processes that govern functional materials, yet measurement noise limits the effective resolution and undermines quantitative analysis. Here, we present a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Samuel Degnan-Morgenstern , Alexander E. Cohen , Rajeev Gopal , Megan Gober , George J. Nelson , Peng Bai , Martin Z. Bazant

Zero-shot denoisers address the dataset dependency of deep-learning-based denoisers, enabling the denoising of unseen single images. Nonetheless, existing zero-shot methods suffer from long training times and rely on the assumption of noise…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yanlin Jiang , Yuchen Liu , Mingren Liu

In general, reliable communication via multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) requires accurate channel estimation at the receiver. The existing literature largely focuses on denoising…

Signal Processing · Electrical Eng. & Systems 2025-08-12 Myeung Suk Oh , Seyyedali Hosseinalipour , Taejoon Kim , Christopher G. Brinton , David J. Love

Microstructure imaging is crucial in materials science, but experimental images often introduce noise that obscures critical structural details. This study presents a novel deep learning approach for robust microstructure image denoising,…

Materials Science · Physics 2025-07-03 Owais Ahmad , Albert Linda , Saumya Ranjan Jha , Somnath Bhowmick

As a hybrid imaging technology, photoacoustic microscopy (PAM) imaging suffers from noise due to the maximum permissible exposure of laser intensity, attenuation of ultrasound in the tissue, and the inherent noise of the transducer.…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Da He , Jiasheng Zhou , Xiaoyu Shang , Jiajia Luo , Sung-Liang Chen

Fluorescence microscopy image (FMI) denoising faces critical challenges due to the compound mixed Poisson-Gaussian noise with strong spatial correlation and the impracticality of acquiring paired noisy/clean data in dynamic biomedical…

Image and Video Processing · Electrical Eng. & Systems 2025-09-25 Jizhihui Liu , Qixun Teng , Qing Ma , Junjun Jiang

One of the fundamental challenges in image restoration is denoising, where the objective is to estimate the clean image from its noisy measurements. To tackle such an ill-posed inverse problem, the existing denoising approaches generally…

Computer Vision and Pattern Recognition · Computer Science 2021-11-12 Lanqing Guo , Siyu Huang , Haosen Liu , Bihan Wen

Denoising is of utmost importance for the visualization and processing of images featuring low signal-to-noise ratio. Total variation methods are among the most popular techniques to perform this task improving the signal-to-noise ratio…

Signal Processing · Electrical Eng. & Systems 2022-01-24 Gonzalo D. Maso Talou , Pablo J. Blanco

We present a fast and accurate analytical method for fluorescence lifetime imaging microscopy (FLIM) using the extreme learning machine (ELM). We used extensive metrics to evaluate ELM and existing algorithms. First, we compared these…

Biological Physics · Physics 2022-03-28 Zhenya Zang , Dong Xiao , Quan Wang , Zinuo Li , Wujun Xie , Yu Chen , David Day Uei Li

Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Xuanyu Tian , Qing Wu , Hongjiang Wei , Yuyao Zhang

Fluorescence lifetime imaging microscopy (FLIM) is a well-established technique with numerous imaging applications. Yet, one of the limitations of FLIM is that it provides information about the emitting state only. Here, we present an…

Biological Physics · Physics 2023-10-27 Pavel Malý , Dita Strachotová , Aleš Holoubek , Petr Heřman
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