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Medical image denoising is considered among the most challenging vision tasks. Despite the real-world implications, existing denoising methods have notable drawbacks as they often generate visual artifacts when applied to heterogeneous…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 S M A Sharif , Rizwan Ali Naqvi , Woong-Kee Loh

We report the development and detailed calibration of a multiphoton fluorescence lifetime imaging system (FLIM) using a streak camera. The present system is versatile with high spatial (0.2 micron) and temporal (50 psec) resolution and…

Quantitative Methods · Quantitative Biology 2009-11-10 R. V. Krishnan , H. Saitoh , H. Terada , V. E. Centonze , B. Herman

Because noise can interfere with downstream analysis, image denoising has come to occupy an important place in the image processing toolbox. The most accurate state-of-the-art denoisers typically train on a representative dataset. But…

Computer Vision and Pattern Recognition · Computer Science 2022-12-06 Jason Lequyer , Wen-Hsin Hsu , Reuben Philip , Anna Christina Erpf , Laurence Pelletier

Salient Object Detection (SOD) with deep learning often requires substantial computational resources and large annotated datasets, making it impractical for resource-constrained applications. Lightweight models address computational demands…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Leonardo M. Joao , Jancarlo F. Gomes , Silvio J. F. Guimaraes , Ewa Kijak , Alexandre X. Falcao

Fluorescence Lifetime Imaging (FLI) is a critical molecular imaging modality that provides unique information about the tissue microenvironment, which is invaluable for biomedical applications. FLI operates by acquiring and analyzing photon…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Ismail Erbas , Vikas Pandey , Navid Ibtehaj Nizam , Nanxue Yuan , Amit Verma , Margarida Barosso , Xavier Intes

Reliable analysis of intracellular dynamic processes in time-lapse fluorescence microscopy images requires complete and accurate tracking of all small particles in all time frames of the image sequences. A fundamental first step towards…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Yao Yao , Ihor Smal , Ilya Grigoriev , Anna Akhmanova , Erik Meijering

With the development of deep learning, medical image processing has been widely used to assist clinical research. This paper focuses on the denoising problem of low-dose computed tomography using deep learning. Although low-dose computed…

Image and Video Processing · Electrical Eng. & Systems 2026-05-19 Zhilin Guan , Wei Zhang

Image denoising is a fundamental problem in computer vision and medical imaging. However, real-world images are often degraded by structured noise with strong anisotropic correlations that existing methods struggle to remove. Most…

Image and Video Processing · Electrical Eng. & Systems 2025-10-03 Jianxu Wang , Ge Wang

Current self-supervised denoising techniques achieve impressive results, yet their real-world application is frequently constrained by substantial computational and memory demands, necessitating a compromise between inference speed and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Tomáš Chobola , Julia A. Schnabel , Tingying Peng

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

Ultrasound images are widespread in medical diagnosis for muscle-skeletal, cardiac, and obstetrical diseases, due to the efficiency and non-invasiveness of the acquisition methodology. However, ultrasound acquisition introduces noise in the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-24 Simone Cammarasana , Paolo Nicolardi , Giuseppe Patanè

Raman spectroscopy enables non-destructive, label-free molecular analysis with high specificity, making it a powerful tool for biomedical diagnostics. However, its application to biological tissues is challenged by inherently weak Raman…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Mengkun Chen , Sanidhya D. Tripathi , James W. Tunnell

Image denoising is a fundamental task in low-level computer vision. While recent deep learning-based image denoising methods have achieved impressive performance, they are black-box models and the underlying denoising principle remains…

Computer Vision and Pattern Recognition · Computer Science 2023-09-27 Jingwei Niu , Jun Cheng , Shan Tan

Magnetic Resonance Imaging (MRI), including diffusion MRI (dMRI), serves as a ``microscope'' for anatomical structures and routinely mitigates the influence of low signal-to-noise ratio scans by compromising temporal or spatial resolution.…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Chenxu Wu , Qingpeng Kong , Zihang Jiang , S. Kevin Zhou

Image denoising is of great importance for medical imaging system, since it can improve image quality for disease diagnosis and downstream image analyses. In a variety of applications, dynamic imaging techniques are utilized to capture the…

Image and Video Processing · Electrical Eng. & Systems 2021-06-24 Junshen Xu , Elfar Adalsteinsson

Image denoising is a prerequisite for downstream tasks in many fields. Low-dose and photon-counting computed tomography (CT) denoising can optimize diagnostic performance at minimized radiation dose. Supervised deep denoising methods are…

Machine Learning · Computer Science 2022-01-06 Chuang Niu , Mengzhou Li , Fenglei Fan , Weiwen Wu , Xiaodong Guo , Qing Lyu , Ge Wang

Flexible intelligent metasurfaces (FIMs) offer a new solution for wireless communications by introducing morphological degrees of freedom, dynamically morphing their three-dimensional shape to ensure multipath signals interfere…

Information Theory · Computer Science 2026-04-08 Jian Xiao , Ji Wang , Qimei Cui , Yucang Yang , Xingwang Li , Dusit Niyato , Chau Yuen

Image denoising is a fundamental challenge in computer vision, with applications in photography and medical imaging. While deep learning-based methods have shown remarkable success, their reliance on specific noise distributions limits…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Dongjin Kim , Jaekyun Ko , Muhammad Kashif Ali , Tae Hyun Kim

Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based…

Image and Video Processing · Electrical Eng. & Systems 2020-08-20 Anna S. Goncharova , Alf Honigmann , Florian Jug , Alexander Krull

In fluorescence microscopy, spectral unmixing aims to recover individual fluorophore concentrations from spectral images that capture mixed fluorophore emissions. Since classical methods operate pixel-wise and rely on least-squares fitting,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Federico Carrara , Talley Lambert , Mehdi Seifi , Florian Jug