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We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…
Tumorigenesis is a complex process that is heterogeneous and affected by numerous sources of variability. This study presents a stochastic extension of a biologically grounded tumor growth model, referred to as the Norton-Simon-Massagu\'e…
We consider a class of multiscale parabolic problems with diffusion coefficients oscillating in space at a possibly small scale $\varepsilon$. Numerical homogenization methods are popular for such problems, because they capture efficiently…
In this paper, a physics-oriented stochastic kinetic scheme will be developed that includes random inputs from both flow and electromagnetic fields via a hybridization of stochastic Galerkin and collocation methods. Based on the BGK-type…
We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…
Tumors initiate when a population of proliferating cells accumulates a certain number and type of genetic and/or epigenetic alterations. The population dynamics of such sequential acquisition of (epi)genetic alterations has been the topic…
This paper studies an evolving bulk--surface finite element method for a model of tissue growth, which is a modification of the model of Eyles, King and Styles (2019). The model couples a Poisson equation on the domain with a forced mean…
In this paper, we present an efficient numerical method to address a thermodynamically consistent gas flow model in porous media involving compressible gas and deformable rock. The accurate modeling of gas flow in porous media often poses…
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a side effect after the irradiation of healthy tissues and organs…
We focus on the numerical analysis of a polygonal discontinuous Galerkin scheme for the simulation of the exchange of fluid between a deformable saturated poroelastic structure and an adjacent free-flow channel. We specifically address wave…
The current paper is devoted to the asymptotic behavior of a class of stochastic PDE. More precisely, with the help of the theory of integrated semigroups and a crucial estimate of the random Stieltjes convolution, we study the existence…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
We address the spatial discretization of an evolution problem arising from the coupling of viscoelastic and acoustic wave propagation phenomena by employing a discontinuous Galerkin scheme on polygonal and polyhedral meshes. The coupled…
We propose a mathematical model that combines elastic, viscous and porous effects with growth or shrinkage due to microstructural changes. This phenomenon is important in tissue or tumor growth, as well as in dermal contraction. Although…
We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…
Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…
We consider a linear kinetic transport equation under a diffusive scaling, that converges to a diffusion equation as the Knudsen number $\varepsilon\rightarrow0$. In [3, 21], to achieve the asymptotic preserving (AP) property and…
This paper studies asymptotic behavior of solutions of a free boundary problem modeling the growth of tumors with two species of cells: proliferating cells and quiecent cells. In previous literatures it has been proved that this problem has…
We investigate a numerical behaviour of robust deterministic optimal control problem subject to a convection diffusion equation containing uncertain inputs. Stochastic Galerkin approach, turning the original optimization problem containing…
This paper is concerned with generalized polynomial chaos (gPC) approximation for a general system of quasilinear hyperbolic conservation laws with uncertainty. The one-dimensional (1D) hyperbolic system is first symmetrized with the aid of…