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Large language models (LLMs) are highly effective in various natural language processing (NLP) tasks. However, they are susceptible to producing unreliable conjectures in ambiguous contexts called hallucination. This paper presents a new…

Computation and Language · Computer Science 2024-03-07 Yuhong Sun , Zhangyue Yin , Qipeng Guo , Jiawen Wu , Xipeng Qiu , Hui Zhao

Multi-round incomplete information tasks are crucial for evaluating the lateral thinking capabilities of large language models (LLMs). Currently, research primarily relies on multiple benchmarks and automated evaluation metrics to assess…

Computation and Language · Computer Science 2025-06-02 Wenhan Dong , Tianyi Hu , Jingyi Zheng , Zhen Sun , Yuemeng Zhao , Yule Liu , Xinlei He , Xinyi Huang

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Large language models (LLMs) inherently operate over a large generation space, yet conventional usage typically reports the most likely generation (MLG) as a point prediction, which underestimates the model's capability: although the…

Computation and Language · Computer Science 2026-03-25 Ye Li , Anqi Hu , Yuanchang Ye , Shiyan Tong , Zhiyuan Wang , Bo Fu

Large language models (LLMs) have shown promise for generative and knowledge-intensive tasks including question-answering (QA) tasks. However, the practical deployment still faces challenges, notably the issue of "hallucination", where…

Computation and Language · Computer Science 2023-10-11 Ziwei Ji , Tiezheng Yu , Yan Xu , Nayeon Lee , Etsuko Ishii , Pascale Fung

Large Language Models (LLMs) are increasingly used for medical entity extraction, yet their confidence scores are often miscalibrated, limiting safe deployment in clinical settings. We present a conformal prediction framework that provides…

Computation and Language · Computer Science 2026-03-10 Manil Shrestha , Edward Kim

The rapid proliferation of large language models and natural language processing (NLP) applications creates a crucial need for uncertainty quantification to mitigate risks such as hallucinations and to enhance decision-making reliability in…

Computation and Language · Computer Science 2024-05-06 Margarida M. Campos , António Farinhas , Chrysoula Zerva , Mário A. T. Figueiredo , André F. T. Martins

Medical large language model (LLM) evaluations rely on simplified, exam-style benchmarks that rarely reflect the ambiguity of real-world medical inquiries. We introduce the CLinical Evaluation of Ambiguity and Reliability (CLEAR) framework,…

Computation and Language · Computer Science 2026-05-12 Kevin H. Guo , Chao Yan , Avinash Baidya , Katherine Brown , Xiang Gao , Juming Xiong , Zhijun Yin , Bradley A. Malin

Current ophthalmology clinical workflows are plagued by over-referrals, long waits, and complex and heterogeneous medical records. Large language models (LLMs) present a promising solution to automate various procedures such as triaging,…

Conformal prediction (CP) offers a principled framework for uncertainty quantification, but it fails to guarantee coverage when faced with missing covariates. In addressing the heterogeneity induced by various missing patterns,…

Machine Learning · Statistics 2025-12-17 Jiarong Fan , Juhyun Park. Thi Phuong Thuy Vo , Nicolas Brunel

Large language models (LLMs) are increasingly used for medical consultation and health information support. In this high-stakes setting, safety depends not only on medical knowledge, but also on how models respond when patient inputs are…

Computation and Language · Computer Science 2026-04-01 Yahan Li , Xinyi Jie , Wanjia Ruan , Xubei Zhang , Huaijie Zhu , Yicheng Gao , Chaohao Du , Ruishan Liu

There is increasing interest in the application large language models (LLMs) to the medical field, in part because of their impressive performance on medical exam questions. While promising, exam questions do not reflect the complexity of…

Selective prediction systems can mitigate harms resulting from language model hallucinations by abstaining from answering in high-risk cases. Uncertainty quantification techniques are often employed to identify such cases, but are rarely…

Computation and Language · Computer Science 2026-03-24 Edward Phillips , Fredrik K. Gustafsson , Sean Wu , Anshul Thakur , David A. Clifton

Hallucination, or the generation of incorrect or fabricated information, remains a critical challenge in large language models (LLMs), particularly in high-stake domains such as legal question answering (QA). In order to mitigate the…

Computation and Language · Computer Science 2025-01-14 Yinghao Hu , Leilei Gan , Wenyi Xiao , Kun Kuang , Fei Wu

In the medical domain, numerous scenarios necessitate the long-form generation ability of large language models (LLMs). Specifically, when addressing patients' questions, it is essential that the model's response conveys factual claims,…

Computation and Language · Computer Science 2024-10-16 Minbyul Jeong , Hyeon Hwang , Chanwoong Yoon , Taewhoo Lee , Jaewoo Kang

Large language models (LLMs) are notorious for hallucinating, i.e., producing erroneous claims in their output. Such hallucinations can be dangerous, as occasional factual inaccuracies in the generated text might be obscured by the rest of…

Large Language Models (LLMs) are powerful linguistic engines but remain susceptible to hallucinations: plausible-sounding outputs that are factually incorrect or unsupported. In this work, we present a mathematically grounded framework to…

Computation and Language · Computer Science 2025-11-20 Moses Kiprono

We develop new conformal inference methods for obtaining validity guarantees on the output of large language models (LLMs). Prior work in conformal language modeling identifies a subset of the text that satisfies a high-probability…

Machine Learning · Statistics 2024-11-01 John J. Cherian , Isaac Gibbs , Emmanuel J. Candès

The deployment of Large Language Models in Medical Question Answering is severely hampered by ambiguous user queries, a significant safety risk that demonstrably reduces answer accuracy in high-stakes healthcare settings. In this paper, we…

Computation and Language · Computer Science 2026-01-27 Yaokun Liu , Yifan Liu , Phoebe Mbuvi , Zelin Li , Ruichen Yao , Gawon Lim , Dong Wang

Large Language Models (LLMs) have been transformative across many domains. However, hallucination, i.e., confidently outputting incorrect information, remains one of the leading challenges for LLMs. This raises the question of how to…

Computation and Language · Computer Science 2026-03-19 Toghrul Abbasli , Kentaroh Toyoda , Yuan Wang , Leon Witt , Muhammad Asif Ali , Yukai Miao , Dan Li , Qingsong Wei