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Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

Quantitative Methods · Quantitative Biology 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas

In the complex realm of cognitive disorders, Alzheimer's disease (AD) and vascular dementia (VaD) are the two most prevalent dementia types, presenting entangled symptoms yet requiring distinct treatment approaches. The crux of effective…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Salma Hassan , Dawlat Akaila , Maryam Arjemandi , Vijay Papineni , Mohammad Yaqub

White-Light Imaging (WLI) is the standard for endoscopic cancer screening, but Narrow-Band Imaging (NBI) offers superior diagnostic details. A key challenge is transferring knowledge from NBI to enhance WLI-only models, yet existing methods…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Qiang Hu , Qimei Wang , Yingjie Guo , Qiang Li , Zhiwei Wang

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting memory, reasoning, communication, and daily functioning. Early diagnosis is particularly important, as timely intervention may…

Sound · Computer Science 2026-05-26 Loukas Ilias , Dimitris Askounis

Compared to other clinical screening techniques, speech-and-language-based automated Alzheimer's disease (AD) detection methods are characterized by their non-invasiveness, cost-effectiveness, and convenience. Previous studies have…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-10 Yin-Long Liu , Rui Feng , Jia-Hong Yuan , Zhen-Hua Ling

The joint utilization of diverse data sources for medical imaging segmentation has emerged as a crucial area of research, aiming to address challenges such as data heterogeneity, domain shift, and data quality discrepancies. Integrating…

Computer Vision and Pattern Recognition · Computer Science 2024-04-04 Eddardaa B. Loussaief , Mohammed Ayad , Domenc Puig , Hatem A. Rashwan

Out-of-distribution (OOD) detection is a critical task for the safe deployment of machine learning models in the real world. Existing prototype-based representation learning methods have demonstrated exceptional performance. Specifically,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Ningkang Peng , JiuTao Zhou , Yuhao Zhang , Xiaoqian Peng , Qianfeng Yu , Linjing Qian , Tingyu Lu , Yi Chen , Yanhui Gu

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Xianrui Li , Yufei Cui , Jun Li , Antoni B. Chan

Multiple types or views of data (e.g. genetics, proteomics) measured on the same set of individuals are now popularly generated in many biomedical studies. A particular interest might be the detection of sample subgroups (e.g. subtypes of…

Methodology · Statistics 2025-05-09 Kaifeng Yang , Thierry Chekouo , Sandra E. Safo

Brain tumor segmentation is often based on multiple magnetic resonance imaging (MRI). However, in clinical practice, certain modalities of MRI may be missing, which presents an even more difficult scenario. To cope with this challenge,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-16 Tianyi Liu , Zhaorui Tan , Haochuan Jiang , Xi Yang , Kaizhu Huang

Medical foundation models pre-trained on large-scale datasets have shown powerful versatile performance. However, when adapting medical foundation models for specific medical scenarios, it remains the inevitable challenge due to the gap…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Siyuan Du , Yuhang Zhou , Haolin Li , Jiangchao Yao , Haishuai Wang , Hui Lin , Ya Zhang , Yanfeng Wang

Multimodal learning enhances the performance of various machine learning tasks by leveraging complementary information across different modalities. However, existing methods often learn multimodal representations that retain substantial…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Tong Zhang , Shu Shen , C. L. Philip Chen

Multimodal biomedical Vision-Language Models (VLMs) exhibit immense potential in the field of Continual Learning (CL). However, they confront a core dilemma: how to preserve fine-grained intra-modality features while bridging the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Zizhi Chen , Yizhen Gao , Minghao Han , Yizhou Liu , Zhaoyu Chen , Dingkang Yang , Lihua Zhang

The prediction of subjects with mild cognitive impairment (MCI) who will progress to Alzheimer's disease (AD) is clinically relevant, and may above all have a significant impact on accelerate the development of new treatments. In this…

Image and Video Processing · Electrical Eng. & Systems 2019-07-16 Kilian Hett , Vinh-Thong Ta , José V. Manjón , Pierrick Coupé

While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of specific modalities is prevalent in clinical practice, severely degrading the performance of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Tianling Liu , Lequan Yu , Tong Han , Liang Wan

Large language models (LLMs) have achieved remarkable performance across diverse domains, yet their enormous computational and memory requirements hinder deployment in resource-constrained environments. Knowledge distillation offers a…

Computation and Language · Computer Science 2026-05-05 Hao Zhang , Zhibin Zhang , Guangxin Wu , Wanyi Ning , Jiafeng Guo , Xueqi Cheng

The current methods for diagnosing Alzheimer Disease using Magnetic Resonance Imaging (MRI) have significant limitations. Many previous studies used 2D Transformers to analyze individual brain slices independently, potentially losing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Juan A. Castro-Silva , Maria N. Moreno Garcia , Diego H. Peluffo-Ordoñez

Source-free domain adaptation (SFDA) alleviates the domain discrepancy among data obtained from domains without accessing the data for the awareness of data privacy. However, existing conventional SFDA methods face inherent limitations in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Yaxuan Song , Jianan Fan , Dongnan Liu , Weidong Cai

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders worldwide. As it progresses, it leads to the deterioration of cognitive functions. Since AD is irreversible, early diagnosis is crucial for managing its…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mahdieh Behjat Khatooni , Mohsen Soryani

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…