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In diagnosing challenging conditions such as Alzheimer's disease (AD), imaging is an important reference. Non-imaging patient data such as patient information, genetic data, medication information, cognitive and memory tests also play a…

Machine Learning · Computer Science 2023-06-01 Yingjie Feng , Jun Wang , Xianfeng Gu , Xiaoyin Xu , Min Zhang

Deep learning models for medical image analysis often act as black boxes, seldom aligning with clinical guidelines or explicitly linking decisions to supporting evidence. This is especially critical in Alzheimer's disease (AD), where…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Qiuhui Chen , Xuancheng Yao , Zhenglei Zhou , Xinyue Hu , Yi Hong

A key challenge in learning from multimodal biological data is missing modalities, where data from one or more modalities are absent for some patients. Existing approaches either exclude patients with missing modalities, impute missing…

Machine Learning · Computer Science 2026-05-19 Sina Tabakhi , Chen , Chen , Haiping Lu

Learning on a massive amount of speech corpus leads to the recent success of many self-supervised speech models. With knowledge distillation, these models may also benefit from the knowledge encoded by language models that are pre-trained…

Computation and Language · Computer Science 2023-03-08 Jinjie Ni , Yukun Ma , Wen Wang , Qian Chen , Dianwen Ng , Han Lei , Trung Hieu Nguyen , Chong Zhang , Bin Ma , Erik Cambria

Alzheimer's disease (AD) is a growing global health challenge as populations age, and timely, accurate diagnosis is essential to reduce individual and societal burden. However, real-world AD assessment is hampered by incomplete,…

While significant work has been done on personality recognition, the lack of multilingual datasets remains an unresolved challenge. To address this, we propose ADAM (Cross-Lingual (A)ttention (D)istillation with Personality-Guided…

Computation and Language · Computer Science 2026-04-13 Jing Jie Tan , Ban-Hoe Kwan , Danny Wee-Kiat Ng , Yan-Chai Hum , Noriyuki Kawarazaki , Kosuke Takano

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder, and early diagnosis is critical for timely intervention. However, most existing classification frameworks face challenges in multicenter studies, as they often neglect…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Fubao Zhu , Zhanyuan Jia , Zhiguo Wang , Huan Huang , Danyang Sun , Chuang Han , Yanting Li , Jiaofen Nan , Chen Zhao , Weihua Zhou

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…

Image and Video Processing · Electrical Eng. & Systems 2026-03-11 Ghulam Nabi Ahmad Hassan Yar , Himashi Peiris , Victoria Mar , Cameron Dennis Pain , Zhaolin Chen

Prototype-based reconstruction methods for unsupervised anomaly detection utilize a limited set of learnable prototypes which only aggregates insufficient normal information, resulting in undesirable reconstruction. However, increasing the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Ziqing Zhou , Yurui Pan , Lidong Wang , Wenbing Zhu , Mingmin Chi , Dong Wu , Bo Peng

Electroencephalography (EEG) is a fundamental modality for cognitive state monitoring in brain-computer interfaces (BCIs). However, it is highly susceptible to intrinsic signal errors and human-induced labeling errors, which lead to label…

Machine Learning · Computer Science 2025-12-15 Hyo-Jeong Jang , Hye-Bin Shin , Seong-Whan Lee

Normative modeling has emerged as a pivotal approach for characterizing heterogeneity and individual variance in neurodegenerative diseases, notably Alzheimer's disease(AD). One of the challenges of cortical normative modeling is the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-13 Jianwei Zhang , Yonggang Shi

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text…

Machine Learning · Computer Science 2025-12-12 Haolin Li , Tianjie Dai , Zhe Chen , Siyuan Du , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Whole-slide images (WSIs) contain tissue information distributed across multiple magnification levels, yet most self-supervised methods treat these scales as independent views. This separation prevents models from learning representations…

Neurobiological and neurodegenerative diseases are inherently multifactorial, arising from coupled influences spanning genetic susceptibility, brain alterations, and environmental and behavioral factors. Multimodal modeling has therefore…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Shaowen Wan , Yanjun Lv , Lu Zhang , Dajiang Zhu , Bharat Biswal , Tianming Liu , Xiaobo Li , Lin Zhao

Accurate prediction of clinical scores is critical for early detection and prognosis of Alzheimers disease (AD). While existing approaches primarily focus on forecasting the ADAS-Cog global score, they often overlook the predictive value of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Nur Amirah Abd Hamid , Mohd Shahrizal Rusli , Muhammad Thaqif Iman Mohd Taufek , Mohd Ibrahim Shapiai , Daphne Teck Ching Lai

Prior research on out-of-distribution detection (OoDD) has primarily focused on single-modality models. Recently, with the advent of large-scale pretrained vision-language models such as CLIP, OoDD methods utilizing such multi-modal…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Jeonghyeon Kim , Sangheum Hwang

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Multimodal fusion leverages information across modalities to learn better feature representations with the goal of improving performance in fusion-based tasks. However, multimodal datasets, especially in medical settings, are typically…

Machine Learning · Computer Science 2025-02-05 Alejandro Guerra-Manzanares , Farah E. Shamout

Accurate segmentation of brain tumors from magnetic resonance imaging (MRI) is clinically relevant in diagnoses, prognoses and surgery treatment, which requires multiple modalities to provide complementary morphological and physiopathologic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-30 Yixin Wang , Yang Zhang , Yang Liu , Zihao Lin , Jiang Tian , Cheng Zhong , Zhongchao Shi , Jianping Fan , Zhiqiang He