Related papers: Modeling Iodine Deficiency
The dead-in-bed syndrome describes the sudden and unexplained death of young individuals with Type 1 Diabetes (T1D) without prior long-term complications. One leading hypothesis attributes this phenomenon to nocturnal hypoglycemia (NH), a…
Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the human body's main source of energy. Fortunately, reaction…
The global prevalence of diabetes, particularly type 2 diabetes mellitus (T2DM), is rapidly increasing, posing significant health and economic challenges. T2DM not only disrupts blood glucose regulation but also damages vital organs such as…
This study investigates the effect of the ion-to-electron temperature ratio ($T_i/T_e$) on microturbulence driven transport in Quiescent H-mode (QH-mode) plasmas in the DIII-D tokamak. Utilizing the Gyrokinetic Toroidal Code (GTC) and the…
The threshold displacement energy (TDE) is the minimum amount of kinetic energy required to displace an atom from its lattice site. The magnitude of the TDE displays significant variance as a function of the crystallographic direction,…
This paper presents an updated framework for studying the ionizing conditions and elemental abundances of photoionized, metal-enriched quasar absorption systems. The standard assumption of ionization equilibrium invoked in absorption line…
Parameterisation of coupled degradation mechanisms in lithium-ion batteries is a major challenge. Interactions between the mechanisms depend on usage conditions: C-rate, rest state-of-charge (SoC), depth-of-discharge (DoD) and temperature.…
Recent experimental observations at JET show evidence of reduced ion temperature profile stiffness, hypothesised to be due to concomitant low magnetic shear (s) and significant toroidal rotational flow shear. Non-linear gyrokinetic…
While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…
Hydroxyapatite (HAp) is the primary mineral component of various mineralized tissues in the human body, including bone and teeth, where it performs critical roles of structural support and load transmission. In the context of dental health,…
Predicting lithium-ion battery lifetime is one of the greatest unsolved problems in battery research right now. Recent years have witnessed a surge in lifetime prediction papers using physics-based, empirical, or data-driven models, most of…
Insulin resistance (IR) is a key precursor to diabetes and a significant risk factor for cardiovascular disease. Traditional IR assessment methods require multiple blood tests. We developed a simple AI model using only fasting blood glucose…
77% of adults over 50 want to age in place today, presenting a major challenge to ensuring adequate nutritional intake. It has been reported that one in four older adults that are 65 years or older are malnourished and given the direct link…
Metabolic syndrome (MetS) is a medication condition characterized by abdominal obesity, insulin resistance, hypertension and hyperlipidemia. It increases the risk of majority of chronic diseases, including type 2 diabetes mellitus, and…
Calcium activation of striated muscle is known to exhibit a strongly cooperative dependency on calcium. Because the calcium receptor protein, troponin (Tn) is known to bind calcium non-cooperatively and has yet to be linked to a cooperative…
Disorder-driven degradation phenomena, such as structural phase transformations and surface reconstructions, can significantly reduce the lifetime of Li-ion batteries, especially those with nickel-rich layered-oxide cathodes. We develop a…
Intrinsically disordered regions (IDRs) of proteins mediate sequence-specific interactions underlying diverse cellular processes, including the formation of biomolecular condensates. Although IDRs strongly influence condensate compositions,…
Accurately predicting blood glucose (BG) levels of ICU patients is critical, as both hypoglycemia (BG < 70 mg/dL) and hyperglycemia (BG > 180 mg/dL) are associated with increased morbidity and mortality. This study presents a…
Known physical mechanisms of temperature dependence anomalies of water properties were used to explain the regularities in temperature dependence (TDs) of dynamic, electrical and optical characteristics of biological systems. The dynamics…
The classical Hodgkin--Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied…