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We present a whole-body model of human metabolism that utilizes a system of organs and blood vessels to simulate the enzymatic reactions. The model focuses on key organs, including the brain, heart and lungs, liver, gut, and kidney, as well…

Quantitative Methods · Quantitative Biology 2023-08-01 Jacob Bendsen , Peter Emil Carstensen , Asbjørn Thode Reenberg , Tobias K. S. Ritschel , John Bagterp Jørgensen

Proper nutrition is very important for the well-being and independence of elderly people. A significant loss of body weight or a decrease of the Body Mass Index respectively is an indicator for malnutrition. A continuous monitoring of the…

Computers and Society · Computer Science 2021-03-11 Björn Friedrich , Jürgen Bauer , Andreas Hein

We investigate microhydration effects on the three low-lying {\pi}* shape resonances of thymine using the Resonance via Pad\'e approach in combination with the DLPNO-EA-EOM-CCSD method. For isolated thymine, the calculated resonance…

Women with polycystic ovary syndrome (PCOS) face substantially elevated risks of body image distress, disordered eating, and metabolic challenges, yet existing natural language processing approaches for detecting these conditions lack…

Computation and Language · Computer Science 2026-05-28 Apoorv Prasad , Susan McRoy

Hysteresis in organic electrochemical transistors (OECT) is a basic effect in which the measured current depends on the voltage sweep direction and velocity. This phenomenon has an important impact on different aspects of the application of…

Applied Physics · Physics 2024-04-29 Juan Bisquert , Baurzhan Ilyassov , Nir Tessler

The rise in chronic diseases over the last century presents a significant health and economic burden globally. Here we apply evolutionary medicine and life history theory to better understand their development. We highlight an imbalanced…

Populations and Evolution · Quantitative Biology 2025-04-15 Jacob E. Aronoff , Benjamin C. Trumble

Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number…

Other Quantitative Biology · Quantitative Biology 2025-04-14 Rinrada Jadsadaphongphaibool , Dadi Bi , Christian D. Lorenz , Yansha Deng , Robert Schober

Ionic electrodiffusion and osmotic water flow are central processes in many physiological systems. We formulate a system of partial differential equations that governs ion movement and water flow in biological tissue. A salient feature of…

Tissues and Organs · Quantitative Biology 2014-10-31 Yoichiro Mori

Aims: We aim to investigate the abundances of light deuterium-bearing species such as HD, H2D+ and D2H+ in a gas-grain chemical model including an extensive description of deuterium and spin state chemistry, in physical conditions…

Astrophysics of Galaxies · Physics 2015-06-15 O. Sipilä , P. Caselli , J. Harju

Ion diffusion is a central part of materials physics of fabrication, deformation, phase transformation, structure stability and electrochemical devices. Conventional theory focuses on the defects that mediate diffusion and explains how…

Materials Science · Physics 2019-08-21 Yanhao Dong , Liang Qi , Ju Li , I-Wei Chen

Yttrium and its alloys are promising materials for high-tech applications, particularly in aerospace and nuclear reactors. The doping of metallic elements at grain boundaries can significantly influence the stability, strength, and…

Materials Science · Physics 2024-11-20 Guanlin Lyu , Yuguo Sun , Ping Qian , Panpan Gao

Understanding physiological responses during running is critical for performance optimization, tailored training prescriptions, and athlete health management. We introduce a comprehensive framework -- what we believe to be the first capable…

Machine Learning · Computer Science 2025-05-02 Barak Gahtan , Sanketh Vedula , Gil Samuelly Leichtag , Einat Kodesh , Alex M. Bronstein

From the past few years, due to advancements in technologies, the sedentary living style in urban areas is at its peak. This results in individuals getting a victim of obesity at an early age. There are various health impacts of obesity…

Machine Learning · Computer Science 2021-08-23 Satvik Garg , Pradyumn Pundir

Modeling and simulating how oxygen supply shapes neuronal excitability is crucial for advancing the understanding of brain function in pathological scenarios, such as ischemia. This condition is caused by a reduced blood supply, leading to…

Numerical Analysis · Mathematics 2026-03-19 Francesco Daniele , Caterina B. Leimer Saglio , Stefano Pagani , Paola F. Antonietti

Solvation of ions is ubiquitous on our planet. Solvated ions have a profound effect on the behavior of ionic solutions, which is crucial in nature and technology. Experimentally, ions have been classified into "structure makers" or…

Soft Condensed Matter · Physics 2021-07-27 Rui Shi , Anthony J. Cooper , Hajime Tanaka

Traditional models of glucose-insulin dynamics rely on heuristic parameterizations chosen to fit observations within a laboratory setting. However, these models cannot describe glucose dynamics in daily life. One source of failure is in…

Machine Learning · Computer Science 2023-05-17 Ke Alexander Wang , Matthew E. Levine , Jiaxin Shi , Emily B. Fox

Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of…

Molecular Networks · Quantitative Biology 2023-08-07 Valérie Voorsluijs , Francesco Avanzini , Gianmaria Falasco , Massimiliano Esposito , Alexander Skupin

The hydration free energies of ions exhibit an approximately quadratic dependence on the ionic charge, as predicted by the Born model. We analyze this behavior using second-order perturbation theory. This provides effective methods to…

chem-ph · Physics 2008-02-03 Gerhard Hummer , Lawrence R. Pratt , Angel E. Garcia

In the Large helical device, a change of energetic particle mode is observed as He concentration is varied in ion-ITB type experiments, having constant electron density and input heating power but with a clear increase of central ion…

Electronically excited atoms or molecules in an environment are often subject to interatomic/intermolecular Coulombic decay (ICD) and/or electron transfer mediated decay (ETMD) mechanisms. A few of the numerous variables that can impact…

Chemical Physics · Physics 2022-09-15 Ravi Kumar , Dr. Nayana Vaval
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