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Generative models show great promise for the inverse design of molecules and inorganic crystals, but remain largely ineffective within more complex structures such as amorphous materials. Here, we present a diffusion model that reliably…

Disordered Systems and Neural Networks · Physics 2026-01-21 Kai Yang , Daniel Schwalbe-Koda

Crystal modeling spans a family of conditional and unconditional generation tasks, including crystal structure prediction (CSP) and de novo generation (DNG). While recent deep generative models have shown promising performance, they remain…

Machine Learning · Computer Science 2026-05-26 Kiyoung Seong , Sungsoo Ahn , Sehui Han , Changyoung Park

Recent endeavors in Multimodal Large Language Models (MLLMs) aim to unify visual comprehension and generation by combining LLM and diffusion models, the state-of-the-art in each task, respectively. Existing approaches rely on spatial visual…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Kaihang Pan , Wang Lin , Zhongqi Yue , Tenglong Ao , Liyu Jia , Wei Zhao , Juncheng Li , Siliang Tang , Hanwang Zhang

Large language models (LLMs) are increasingly being used in materials science. However, little attention has been given to benchmarking and standardized evaluation for LLM-based materials property prediction, which hinders progress. We…

Materials Science · Physics 2024-12-03 Andre Niyongabo Rubungo , Kangming Li , Jason Hattrick-Simpers , Adji Bousso Dieng

In condensed matter physics and materials science, predicting material properties necessitates understanding intricate many-body interactions. Conventional methods such as density functional theory (DFT) and molecular dynamics (MD) often…

Materials Science · Physics 2023-11-17 Lalit Yadav

The design of materials with tailored properties is crucial for technological progress. However, most deep generative models focus exclusively on perfectly ordered crystals, neglecting the important class of disordered materials. To address…

Machine Learning · Computer Science 2026-02-05 Liming Wu , Rui Jiao , Qi Li , Mingze Li , Songyou Li , Shifeng Jin , Wenbing Huang

The use of machine learning methods for accelerating the design of crystalline materials usually requires manually constructed feature vectors or complex transformation of atom coordinates to input the crystal structure, which either…

Materials Science · Physics 2018-04-10 Tian Xie , Jeffrey C. Grossman

Materials property predictions have improved from advances in machine learning algorithms, delivering materials discoveries and novel insights through data-driven models of structure-property relationships. Nearly all available models rely…

Materials Science · Physics 2022-04-13 Yiqun Wang , Xiao-Jie Zhang , Fei Xia , Elsa A. Olivetti , Ram Seshadri , James M. Rondinelli

The application of language models (LMs) to molecular structure generation using line notations such as SMILES and SELFIES has been well-established in the field of cheminformatics. However, extending these models to generate 3D molecular…

Machine Learning · Computer Science 2024-12-03 Kaiyuan Gao , Yusong Wang , Haoxiang Guan , Zun Wang , Qizhi Pei , John E. Hopcroft , Kun He , Lijun Wu

A line of work in planning uses LLM not to generate a plan, but to generate a formal representation in some planning language, which can be input into a symbolic solver to deterministically find a plan. While showing improved trust and…

Computation and Language · Computer Science 2025-10-08 Prabhu Prakash Kagitha , Bo Sun , Ishan Desai , Andrew Zhu , Cassie Huang , Manling Li , Ziyang Li , Li Zhang

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both…

Biomolecules · Quantitative Biology 2025-03-19 Qizhi Pei , Rui Yan , Kaiyuan Gao , Jinhua Zhu , Lijun Wu

We introduce CrystalFormer, a transformer-based autoregressive model specifically designed for space group-controlled generation of crystalline materials. By explicitly incorporating space group symmetry, CrystalFormer greatly reduces the…

Materials Science · Physics 2025-09-29 Zhendong Cao , Xiaoshan Luo , Jian Lv , Lei Wang

Tokenising continuous speech into sequences of discrete tokens and modelling them with language models (LMs) has led to significant success in text-to-speech (TTS) synthesis. Although these models can generate speech with high quality and…

Sound · Computer Science 2024-08-30 Zehai Tu , Guangyan Zhang , Yiting Lu , Adaeze Adigwe , Simon King , Yiwen Guo

Accelerating inverse design of crystalline materials with generative models has significant implications for a range of technologies. Unlike other atomic systems, 3D crystals are invariant to discrete groups of isometries called the space…

Materials Science · Physics 2025-10-27 Rees Chang , Angela Pak , Alex Guerra , Ni Zhan , Nick Richardson , Elif Ertekin , Ryan P. Adams

Protein structure tokenization converts 3D structures into discrete or vectorized representations, enabling the integration of structural and sequence data. Despite many recent works on structure tokenization, the properties of the…

Machine Learning · Computer Science 2025-11-14 Zijing Liu , Bin Feng , He Cao , Yu Li

Determining whether a candidate crystalline material is thermodynamically stable depends on identifying its true ground-state structure, a central challenge in computational materials science. We introduce CrystalGRW, a diffusion-based…

While Large Language Models (LLMs) are increasingly used for synthesizing textual PLC programming languages like Structured Text (ST) code, other IEC 61131-3 standard graphical languages like Sequential Function Charts (SFCs) remain…

Computation and Language · Computer Science 2025-12-09 Ofek Glick , Vladimir Tchuiev , Marah Ghoummaid , Michal Moshkovitz , Dotan Di-Castro

Multimedia generation approaches occupy a prominent place in artificial intelligence research. Text-to-image models achieved high-quality results over the last few years. However, video synthesis methods recently started to develop. This…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Vladimir Arkhipkin , Zein Shaheen , Viacheslav Vasilev , Elizaveta Dakhova , Andrey Kuznetsov , Denis Dimitrov

Automatic material discovery with desired properties is a fundamental challenge for material sciences. Considerable attention has recently been devoted to generating stable crystal structures. While existing work has shown impressive…

Machine Learning · Computer Science 2023-02-02 Astrid Klipfel , Olivier Peltre , Najwa Harrati , Yaël Fregier , Adlane Sayede , Zied Bouraoui

In computational molecular and materials science, determining equilibrium structures is the crucial first step for accurate subsequent property calculations. However, the recent discovery of millions of new crystals and complex twisted…

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