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The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

Large Language Models (LLMs) have achieved impressive progress in natural language processing, but their limited ability to retain long-term context constrains performance on document-level or multi-turn tasks. Retrieval-Augmented…

Computation and Language · Computer Science 2025-05-20 Zhangyu Wang , Siyuan Gao , Rong Zhou , Hao Wang , Li Ning

Large language models (LLMs) can be adapted to new tasks using parameter-efficient fine-tuning (PEFT) methods that modify only a small number of trainable parameters, often through low-rank updates. In this work, we adopt a…

Machine Learning · Computer Science 2026-01-27 Min Chen , Zihan Wang , Canyu Chen , Zeguan Wu , Manling Li , Junyu Liu

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

Genomics · Quantitative Biology 2025-02-19 Wang Liang

Recovering the structure of causal graphical models from observational data is an essential yet challenging task for causal discovery in scientific scenarios. Domain-specific causal discovery usually relies on expert validation or prior…

Artificial Intelligence · Computer Science 2025-08-27 Taiyu Ban , Lyuzhou Chen , Derui Lyu , Xiangyu Wang , Qinrui Zhu , Qiang Tu , Huanhuan Chen

Large Language Models (LLMs) have revolutionized the field of natural language processing, but they fall short in comprehending biological sequences such as proteins. To address this challenge, we propose InstructProtein, an innovative LLM…

Biomolecules · Quantitative Biology 2023-10-06 Zeyuan Wang , Qiang Zhang , Keyan Ding , Ming Qin , Xiang Zhuang , Xiaotong Li , Huajun Chen

In the developer community for large language models (LLMs), there is not yet a clean pattern analogous to a software library, to support very large scale collaboration. Even for the commonplace use case of Retrieval-Augmented Generation…

Large Language Models (LLMs) have shown strong performance in text-based healthcare tasks. However, their utility in image-based applications remains unexplored. We investigate the effectiveness of LLMs for medical imaging tasks,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Felicia Liu , Jay J. Yoo , Farzad Khalvati

Large decoder-only language models (LLMs) have achieved remarkable success in generation and reasoning tasks, where they generate text responses given instructions. However, many applications, e.g., retrieval augmented generation (RAG),…

Computation and Language · Computer Science 2025-06-06 Caojin Zhang , Qiang Zhang , Ke Li , Sai Vidyaranya Nuthalapati , Benyu Zhang , Jason Liu , Serena Li , Lizhu Zhang , Xiangjun Fan

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

The advent of Large Language Models (LLMs) is promising and LLMs have been applied to numerous fields. However, it is not trivial to implement LLMs in the medical field, due to the high standards for precision and accuracy. Currently, the…

Information Retrieval · Computer Science 2024-12-04 Rishabh Goel

The prediction of amyloidogenicity in peptides and proteins remains a focal point of ongoing bioinformatics. The crucial step in this field is to apply advanced computational methodologies. Many recent approaches to predicting…

Machine Learning · Computer Science 2025-08-19 Zohra Yagoub , Hafida Bouziane

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Recently, Large Language Models (LLMs) have achieved significant success, prompting increased interest in expanding their generative capabilities beyond general text into domain-specific areas. This study investigates the generation of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Jiahao Li , Weijian Ma , Xueyang Li , Yunzhong Lou , Guichun Zhou , Xiangdong Zhou

Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim

Word segmentation stands as a cornerstone of Natural Language Processing (NLP). Based on the concept of "comprehend first, segment later", we propose a new framework to explore the limit of unsupervised word segmentation with Large Language…

Computation and Language · Computer Science 2025-05-27 Zihong Zhang , Liqi He , Zuchao Li , Lefei Zhang , Hai Zhao , Bo Du

Large Language Models (LLMs) have demonstrated superior results across a wide range of tasks, and Retrieval-augmented Generation (RAG) is an effective way to enhance the performance by locating relevant information and placing it into the…

Computation and Language · Computer Science 2024-02-22 Zixuan Ke , Weize Kong , Cheng Li , Mingyang Zhang , Qiaozhu Mei , Michael Bendersky

Large language models (LLMs) excel in many natural language processing (NLP) tasks. However, since LLMs can only incorporate new knowledge through training or supervised fine-tuning processes, they are unsuitable for applications that…

Databases · Computer Science 2024-07-23 Zongyue Qin , Chen Luo , Zhengyang Wang , Haoming Jiang , Yizhou Sun

In large scale recommendation systems like the LinkedIn Feed, the retrieval stage is critical for narrowing hundreds of millions of potential candidates to a manageable subset for ranking. LinkedIn's Feed serves suggested content from…

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