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Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He

Nuclear segmentation in histology images is a challenging task due to significant variations in the shape and appearance of nuclei. One of the main hurdles in nuclear instance segmentation is overlapping nuclei where a smart algorithm is…

Image and Video Processing · Electrical Eng. & Systems 2019-08-28 Navid Alemi Koohbanani , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Few-shot instance segmentation (FSIS) conjoins the few-shot learning paradigm with general instance segmentation, which provides a possible way of tackling instance segmentation in the lack of abundant labeled data for training. This paper…

Computer Vision and Pattern Recognition · Computer Science 2020-04-01 Zhibo Fan , Jin-Gang Yu , Zhihao Liang , Jiarong Ou , Changxin Gao , Gui-Song Xia , Yuanqing Li

In computational pathology, nuclear instance segmentation is a fundamental task with many downstream clinical applications. With the advent of deep learning, many approaches, including convolutional neural networks (CNNs) and vision…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Amirreza Mahbod , Ramona Woitek , Jeanne Shen

Existing few-shot segmentation (FSS) only considers learning support-query correlation and segmenting unseen categories under the precise pixel masks. However, the cost of a large number of pixel masks during training is expensive. This…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Xinyang Huang , Chuang Zhu , Kebin Liu , Ruiying Ren , Shengjie Liu

Nuclei instance segmentation in histopathological images is of great importance for biological analysis and cancer diagnosis but remains challenging for two reasons. (1) Similar visual presentation of intranuclear and extranuclear regions…

Computer Vision and Pattern Recognition · Computer Science 2024-02-12 Ye Zhang , Linghan Cai , Ziyue Wang , Yongbing Zhang

Nuclear segmentation is important and frequently demanded for pathology image analysis, yet is also challenging due to nuclear crowdedness and possible occlusion. In this paper, we present a novel bottom-up method for nuclear segmentation.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-11 Jiahui Li , Zhiqiang Hu , Shuang Yang

Separating and labeling each instance of a nucleus (instance-aware segmentation) is the key challenge in segmenting single cell nuclei on fluorescence microscopy images. Deep Neural Networks can learn the implicit transformation of a…

Computer Vision and Pattern Recognition · Computer Science 2021-08-11 Florian Kromp , Lukas Fischer , Eva Bozsaky , Inge Ambros , Wolfgang Doerr , Sabine Taschner-Mandl , Peter Ambros , Allan Hanbury

Nuclei segmentation is a fundamental task in histopathology image analysis. Typically, such segmentation tasks require significant effort to manually generate accurate pixel-wise annotations for fully supervised training. To alleviate such…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Hui Qu , Pengxiang Wu , Qiaoying Huang , Jingru Yi , Zhennan Yan , Kang Li , Gregory M. Riedlinger , Subhajyoti De , Shaoting Zhang , Dimitris N. Metaxas

We present a weakly supervised instance segmentation algorithm based on deep community learning with multiple tasks. This task is formulated as a combination of weakly supervised object detection and semantic segmentation, where individual…

Computer Vision and Pattern Recognition · Computer Science 2020-11-19 Jaedong Hwang , Seohyun Kim , Jeany Son , Bohyung Han

Image segmentation plays an essential role in nuclei image analysis. Recently, the segment anything model has made a significant breakthrough in such tasks. However, the current model exists two major issues for cell segmentation: (1) the…

Image and Video Processing · Electrical Eng. & Systems 2023-08-24 Qing Xu , Wenwei Kuang , Zeyu Zhang , Xueyao Bao , Haoran Chen , Wenting Duan

Cell instance segmentation is a new and challenging task aiming at joint detection and segmentation of every cell in an image. Recently, many instance segmentation methods have applied in this task. Despite their great success, there still…

Computer Vision and Pattern Recognition · Computer Science 2022-08-18 Menghao Li , Wenquan Feng , Shuchang Lyu , Lijiang Chen , Qi Zhao

Due to the wide existence and large morphological variances of nuclei, accurate nuclei instance segmentation is still one of the most challenging tasks in computational pathology. The annotating of nuclei instances, requiring experienced…

Computer Vision and Pattern Recognition · Computer Science 2020-07-23 Xinpeng Xie , Jiawei Chen , Yuexiang Li , Linlin Shen , Kai Ma , Yefeng Zheng

Weakly supervised instance segmentation reduces the cost of annotations required to train models. However, existing approaches which rely only on image-level class labels predominantly suffer from errors due to (a) partial segmentation of…

Computer Vision and Pattern Recognition · Computer Science 2021-03-25 Qing Liu , Vignesh Ramanathan , Dhruv Mahajan , Alan Yuille , Zhenheng Yang

Accurate nuclear instance segmentation is a pivotal task in computational pathology, supporting data-driven clinical insights and facilitating downstream translational applications. While large vision foundation models have shown promise…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Wen Zhang , Qin Ren , Wenjing Liu , Haibin Ling , Chenyu You

Weakly-supervised instance segmentation, which could greatly save labor and time cost of pixel mask annotation, has attracted increasing attention in recent years. The commonly used pipeline firstly utilizes conventional image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-12-13 Shisha Liao , Yongqing Sun , Chenqiang Gao , Pranav Shenoy K P , Song Mu , Jun Shimamura , Atsushi Sagata

Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Inwan Yoo , Donggeun Yoo , Kyunghyun Paeng

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Deep learning has demonstrated significant potential in medical imaging; however, the opacity of "black-box" models hinders clinical trust, while segmentation tasks typically necessitate labourious, hard-to-obtain pixel-wise annotations. To…

Image and Video Processing · Electrical Eng. & Systems 2026-01-22 Soumick Chatterjee , Hadya Yassin , Florian Dubost , Andreas Nürnberger , Oliver Speck

Accurate nuclei segmentation in histopathological images is crucial for cancer diagnosis. Automating this process offers valuable support to clinical experts, as manual annotation is time-consuming and prone to human errors. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Ayush Roy , Payel Pramanik , Dmitrii Kaplun , Sergei Antonov , Ram Sarkar
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