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Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

Image and Video Processing · Electrical Eng. & Systems 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

The development of robust artificial intelligence models for histopathology diagnosis is severely constrained by the scarcity of expert-annotated lesion data, particularly for rare pathologies and underrepresented disease subtypes. While…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Mohamad Koohi-Moghadam , Mohammad-Ali Nikouei Mahani , Kyongtae Tyler Bae

A large labeled dataset is a key to the success of supervised deep learning, but for medical image segmentation, it is highly challenging to obtain sufficient annotated images for model training. In many scenarios, unannotated images are…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Hao Zheng , Jun Han , Hongxiao Wang , Lin Yang , Zhuo Zhao , Chaoli Wang , Danny Z. Chen

High-quality, large-scale data is essential for robust deep learning models in medical applications, particularly ultrasound image analysis. Diffusion models facilitate high-fidelity medical image generation, reducing the costs associated…

Image and Video Processing · Electrical Eng. & Systems 2024-04-01 Pooria Ashrafian , Milad Yazdani , Moein Heidari , Dena Shahriari , Ilker Hacihaliloglu

Histological analysis of tissue samples is one of the most widely used methods for disease diagnosis. After taking a sample from a patient, it goes through a lengthy and laborious preparation, which stains the tissue to visualize different…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Yair Rivenson , Hongda Wang , Zhensong Wei , Yibo Zhang , Harun Gunaydin , Aydogan Ozcan

The availability of large-scale chest X-ray datasets is a requirement for developing well-performing deep learning-based algorithms in thoracic abnormality detection and classification. However, biometric identifiers in chest radiographs…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Kai Packhäuser , Lukas Folle , Florian Thamm , Andreas Maier

Delineating and classifying individual cells in microscopy tissue images is inherently challenging yet remains essential for advancements in medical and neuroscientific research. In this work, we propose a new deep learning framework,…

Image and Video Processing · Electrical Eng. & Systems 2025-02-11 Valentina Vadori , Jean-Marie Graïc , Antonella Peruffo , Giulia Vadori , Livio Finos , Enrico Grisan

Long-tailed class distributions are pervasive in multi-class medical datasets and pose significant challenges for deep learning models which typically underperform on tail classes with limited samples. This limitation is particularly…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Jiaxiang Jiang , Mahesh Subedar , Omesh Tickoo

The lack of well-annotated datasets in computational pathology (CPath) obstructs the application of deep learning techniques for classifying medical images. %Since pathologist time is expensive, dataset curation is intrinsically difficult.…

Image and Video Processing · Electrical Eng. & Systems 2022-01-28 Ryan Zhang , Jiadai Zhu , Stephen Yang , Mahdi S. Hosseini , Angelo Genovese , Lina Chen , Corwyn Rowsell , Savvas Damaskinos , Sonal Varma , Konstantinos N. Plataniotis

In this article, we present a Latent Diffusion Model (LDM) for the generation of brain Magnetic Resonance Imaging (MRI), conditioning its generation based on pathology (Healthy, Glioblastoma, Sclerosis, Dementia) and acquisition modality…

This paper presents a study on few-shot classification in the context of histopathology images. While few-shot learning has been studied for natural image classification, its application to histopathology is relatively unexplored. Given the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Ardhendu Sekhar , Ravi Kant Gupta , Amit Sethi

Predictive modeling is useful but very challenging in biological image analysis due to the high cost of obtaining and labeling training data. For example, in the study of gene interaction and regulation in Drosophila embryogenesis, the…

Machine Learning · Computer Science 2020-10-21 Lei Cai , Zhengyang Wang , Rob Kulathinal , Sudhir Kumar , Shuiwang Ji

This technical report outlines our method for generating a synthetic dataset for semantic segmentation using a latent diffusion model. Our approach eliminates the need for additional models specifically trained on segmentation data and is…

Computer Vision and Pattern Recognition · Computer Science 2024-06-26 Felix Stillger , Frederik Hasecke , Tobias Meisen

With the rapid development of deep learning technology and improvement in computing capability, deep learning has been widely used in the field of hyperspectral image (HSI) classification. In general, deep learning models often contain many…

Computer Vision and Pattern Recognition · Computer Science 2021-12-06 Sen Jia , Shuguo Jiang , Zhijie Lin , Nanying Li , Meng Xu , Shiqi Yu

Large-scale, big-variant, high-quality data are crucial for developing robust and successful deep-learning models for medical applications since they potentially enable better generalization performance and avoid overfitting. However, the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Zheyuan Zhang , Lanhong Yao , Bin Wang , Debesh Jha , Gorkem Durak , Elif Keles , Alpay Medetalibeyoglu , Ulas Bagci

Aside from offering state-of-the-art performance in medical image generation, denoising diffusion probabilistic models (DPM) can also serve as a representation learner to capture semantic information and potentially be used as an image…

Image and Video Processing · Electrical Eng. & Systems 2024-07-09 Chun-Mei Feng

Semi-supervised learning utilizes insights from unlabeled data to improve model generalization, thereby reducing reliance on large labeled datasets. Most existing studies focus on limited samples and fail to capture the overall data…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Xiuzhen Guo , Lianyuan Yu , Ji Shi , Na Lei , Hongxiao Wang

Augmentation for dense prediction typically relies on either sample mixing or generative synthesis. Mixing improves robustness but misaligned masks yield soft label ambiguity. Diffusion synthesis increases apparent diversity but, when…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Pengyu Jie , Wanquan Liu , Rui He , Yihui Wen , Deyu Meng , Chenqiang Gao

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

Accurate segmentation of cell nuclei in histopathology images is essential for numerous biomedical research and clinical applications. However, existing cell nucleus segmentation methods only consider a single dataset (i.e., primary…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Jiahe Qian , Yaoyu Fang , Jinkui Hao , Bo Zhou