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The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Diffusion models and flow-matching models have enabled generating diverse and realistic images by learning to transfer noise to data. However, sampling from these models involves iterative denoising over many neural network passes, making…

Machine Learning · Computer Science 2025-06-24 Kevin Frans , Danijar Hafner , Sergey Levine , Pieter Abbeel

Surgical scene segmentation is essential for enhancing surgical precision, yet it is frequently compromised by the scarcity and imbalance of available data. To address these challenges, semantic image synthesis methods based on generative…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Yihang Zhou , Rebecca Towning , Zaid Awad , Stamatia Giannarou

Histopathology, the microscopic study of diseased tissue, is increasingly digitized, enabling improved visualization and streamlined workflows. An important task in histopathology is the segmentation of cells and glands, essential for…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Philipp Endres , Valentin Koch , Julia A. Schnabel , Carsten Marr

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

In hyperspectral remote sensing field, some downstream dense prediction tasks, such as semantic segmentation (SS) and change detection (CD), rely on supervised learning to improve model performance and require a large amount of manually…

Computer Vision and Pattern Recognition · Computer Science 2025-02-25 Wendi Liu , Pei Yang , Wenhui Hong , Xiaoguang Mei , Jiayi Ma

Diffusion Probabilistic Models have recently shown remarkable performance in generative image modeling, attracting significant attention in the computer vision community. However, while a substantial amount of diffusion-based research has…

Computer Vision and Pattern Recognition · Computer Science 2023-07-12 Yijun Yang , Huazhu Fu , Angelica I. Aviles-Rivero , Carola-Bibiane Schönlieb , Lei Zhu

Accurately identifying oocytes that progress to the blastocyst stage is crucial in reproductive medicine, but the limited availability of annotated high-quality embryo images presents challenges for developing automated diagnostic tools. To…

Quantitative Methods · Quantitative Biology 2025-06-18 Alejandro Golfe , Natalia P. García-de-la-puente , Adrián Colomer , Valery Naranjo

Accurate classification of sleep stages based on bio-signals is fundamental not only for automatic sleep stage annotation, but also for clinical health management and continuous sleep monitoring. Traditionally, this task relies on…

Machine Learning · Computer Science 2025-09-09 Jingyu Li , Tiehua Zhang , Jinze Wang , Yi Zhang , Yuhuan Li , Yifan Zhao , Zhishu Shen , Libing Wu , Jiannan Liu

By decomposing the image formation process into a sequential application of denoising autoencoders, diffusion models (DMs) achieve state-of-the-art synthesis results on image data and beyond. Additionally, their formulation allows for a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Robin Rombach , Andreas Blattmann , Dominik Lorenz , Patrick Esser , Björn Ommer

Few-shot learning is an established topic in natural images for years, but few work is attended to histology images, which is of high clinical value since well-labeled datasets and rare abnormal samples are expensive to collect. Here, we…

Image and Video Processing · Electrical Eng. & Systems 2022-02-21 Jiawei Yang , Hanbo Chen , Jiangpeng Yan , Xiaoyu Chen , Jianhua Yao

Weakly supervised semantic segmentation (WSSS) in histopathology seeks to reduce annotation cost by learning from image-level labels, yet it remains limited by inter-class homogeneity, intra-class heterogeneity, and the region-shrinkage…

In microscopy image cell segmentation, it is common to train a deep neural network on source data, containing different types of microscopy images, and then fine-tune it using a support set comprising a few randomly selected and annotated…

Computer Vision and Pattern Recognition · Computer Science 2022-11-21 Youssef Dawoud , Arij Bouazizi , Katharina Ernst , Gustavo Carneiro , Vasileios Belagiannis

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Widely adopted medical image segmentation methods, although efficient, are primarily deterministic and remain poorly amenable to natural language prompts. Thus, they lack the capability to estimate multiple proposals, human interaction, and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Yuan Lin , Murong Xu , Marc Hölle , Chinmay Prabhakar , Andreas Maier , Vasileios Belagiannis , Bjoern Menze , Suprosanna Shit

The acquisition of annotated datasets with paired images and segmentation masks is a critical challenge in domains such as medical imaging, remote sensing, and computer vision. Manual annotation demands significant resources, faces ethical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Rupak Bose , Chinedu Innocent Nwoye , Aditya Bhat , Nicolas Padoy

The task of layout-to-image generation involves synthesizing images based on the captions of objects and their spatial positions. Existing methods still struggle in complex layout generation, where common bad cases include object missing,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Bo Cheng , Yuhang Ma , Liebucha Wu , Shanyuan Liu , Ao Ma , Xiaoyu Wu , Dawei Leng , Yuhui Yin

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Anatomical Landmark Detection is the process of identifying key areas of an image for clinical measurements. Each landmark is a single ground truth point labelled by a clinician. A machine learning model predicts the locus of a landmark as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-15 Julian Wyatt , Irina Voiculescu