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Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

This paper explores the links between Knowledge Management and new community-based models of the organization from both a theoretical and an empirical perspective. From a theoretical standpoint, we look at Communities of Practice (CoPs) and…

Human-Computer Interaction · Computer Science 2008-04-18 Isabelle Bourdon , Chris Kimble

As global discourse on AI regulation gains momentum, this paper focuses on delineating the impact of ML on autonomy and fostering awareness. Respect for autonomy is a basic principle in bioethics that establishes persons as decision-makers.…

Computers and Society · Computer Science 2025-10-23 Paula Subías-Beltrán , Oriol Pujol , Itziar de Lecuona

The Machine Consciousness Hypothesis states that consciousness is a substrate-free functional property of computational systems capable of second-order perception. I propose a research program to investigate this idea in silico by studying…

Artificial Intelligence · Computer Science 2025-12-02 Stephen Fitz

Many automatically analyzable scientific questions are well-posed and offer a variety of information about the expected outcome a priori. Although often being neglected, this prior knowledge can be systematically exploited to make automated…

Computer Vision and Pattern Recognition · Computer Science 2018-02-07 Johannes Stegmaier , Ralf Mikut

Various features of the development of individual living species, including individual humans, are programmed. Is death also programmed, and if yes, how is it implemented and what can be the underlying mechanism providing the inevitability…

Chaotic Dynamics · Physics 2019-05-23 Mark Edelman

Understanding human behavior from observed data is critical for transparency and accountability in decision-making. Consider real-world settings such as healthcare, in which modeling a decision-maker's policy is challenging -- with no…

Machine Learning · Statistics 2023-11-01 Alihan Hüyük , Daniel Jarrett , Mihaela van der Schaar

Active systems across scales, ranging from molecular machines to human crowds, are usually modeled as assemblies of self-propelled particles driven by internally generated forces. However, these models often assume memoryless dynamics and…

Statistical Mechanics · Physics 2025-12-10 Marc Besse , Raphaël Voituriez

Achieving greater autonomy in automation systems is crucial for handling unforeseen situations effectively. However, this remains challenging due to technological limitations and the complexity of real-world environments. This paper…

Computational Engineering, Finance, and Science · Computer Science 2025-07-08 Johannes Sigel , Daniel Dittler , Nasser Jazdi , Michael Weyrich

Information-theoretic measures have been widely adopted in the design of features for learning and decision problems. Inspired by this, we look at the relationship between i) a weak form of information loss in the Shannon sense and ii) the…

Machine Learning · Computer Science 2022-01-03 Jorge F. Silva , Felipe Tobar , Mario Vicuña , Felipe Cordova

Intelligent systems deployed in the real world suffer from catastrophic forgetting when exposed to a sequence of tasks. Humans, on the other hand, acquire, consolidate, and transfer knowledge between tasks that rarely interfere with the…

Machine Learning · Computer Science 2023-02-23 Prashant Bhat , Bahram Zonooz , Elahe Arani

Ethical software development remains stubbornly difficult despite two decades of normative frameworks, professional codes, and participatory methodologies. This paper offers a diagnostic rather than prescriptive contribution: it argues that…

Computers and Society · Computer Science 2026-04-28 Jan Gogoll

Large language models deployed as autonomous agents face critical memory limitations, lacking selective forgetting mechanisms that lead to either catastrophic forgetting at context boundaries or information overload within them. While human…

Artificial Intelligence · Computer Science 2026-02-09 Lei Wei , Xiao Peng , Xu Dong , Niantao Xie , Bin Wang

Self-sustaining autocatalytic networks play a central role in living systems, from metabolism at the origin of life, simple RNA networks, and the modern cell, to ecology and cognition. A collectively autocatalytic network that can be…

Molecular Networks · Quantitative Biology 2018-03-29 Mike Steel , Wim Hordijk

Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved and designed material and software. These…

Tissues and Organs · Quantitative Biology 2022-01-26 Michael Levin

Mutual misunderstanding in contemporary society does not arise merely because people hold different opinions or values. Even under the same observations, different subjects may form different inferential targets, state representations,…

Artificial Intelligence · Computer Science 2026-05-29 Toru Takahashi

Awareness structures by Fagin and Halpern (1988) (FH) feature a syntactic awareness correspondence and accessibility relations modeling implicit knowledge. They are a flexible model of unawareness, and best interpreted from a outside…

Logic in Computer Science · Computer Science 2023-07-12 Gaia Belardinelli , Burkhard C. Schipper

Microorganisms employ sophisticated mechanisms for intercellular communication and environmental sensing, with quorum sensing serving as a fundamental regulatory process. Dysregulation of quorum sensing has been implicated in various…

Emerging Technologies · Computer Science 2025-09-30 O. Tansel Baydas , Efe Yatgin , Ozgur B. Akan

In this paper we investigate the homeostatic mechanism in two biologically motivated models: intracellular copper regulation and self immune recognition. The analysis is based on the notions of infinitesimal homeostasis and near-perfect…

Molecular Networks · Quantitative Biology 2022-02-24 Pedro P. A. Cardoso de Andrade , João L. O. Madeira , Fernando Antoneli

The managed-metabolism hypothesis suggests that a cooperation barrier must be overcome if self-producing chemical organizations are to transition from non-life to life. This barrier prevents un-managed, self-organizing, autocatalytic…

Populations and Evolution · Quantitative Biology 2018-08-06 John E. Stewart
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