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Here we apply hyperspectral bright field imaging to collect computed tomographic images with excellent energy resolution (800 eV), applying it for the first time to map the distribution of stain in a fixed biological sample through its…

Accurately determining the crystallographic structure of a material, organic or inorganic, is a critical primary step in material development and analysis. The most common practices involve analysis of diffraction patterns produced in…

A new method for dark field imaging is introduced which uses scanned electron diffraction (or 4DSTEM - 4-dimensional scanning transmission electron microscopy) datasets as its input. Instead of working on simple summation of intensity, it…

Materials Science · Physics 2024-09-18 Ian MacLaren , Andrew T. Fraser , Matthew R. Lipsett , Colin Ophus

Determining the 3D structures of biological molecules is a key problem for both biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising technique for structure estimation which relies heavily on computational methods to…

Machine Learning · Statistics 2015-01-29 Ali Punjani , Marcus A. Brubaker

Three-dimensional atomic resolution imaging using transmission electron microscopes is a unique capability that requires challenging experiments. Linear electron tomography methods are limited by the missing wedge effect, requiring a high…

Computational Physics · Physics 2024-07-30 Shengboy You , Andrey Romanov , Philipp Pelz

Ptychography is a popular imaging technique that combines diffractive imaging with scanning microscopy. The technique consists of a coherent beam that is scanned across an object in a series of overlapping positions, leading to reliable and…

Numerical Analysis · Mathematics 2019-02-20 Samy Wu Fung , Zichao Di

Consistency relations of large-scale structure offer a unique and powerful test of the weak equivalence principle (EP) on cosmological scales. If the EP is violated, different tracers will undergo different accelerations in response to a…

Cosmology and Nongalactic Astrophysics · Physics 2025-12-19 Lawrence Dam , Omar Darwish

Ptychography, as a powerful lensless imaging method, has become a popular member of the coherent diffractive imaging family over decades of development. The ability to utilize low-dose X-rays and/or fast scans offers a big advantage in a…

Medical Physics · Physics 2024-06-14 Longlong Wu , Shinjae Yoo , Yong S. Chu , Xiaojing Huang , Ian K. Robinson

Material properties strongly depend on the nature and concentration of defects. Characterizing these features may require nano- to atomic-scale resolution to establish structure-property relationships. 4D-STEM, a technique where diffraction…

Materials Science · Physics 2023-05-03 Stephanie M. Ribet , Colin Ophus , Roberto dos Reis , Vinayak P. Dravid

Ptychography is an attractive advance of coherent diffraction imaging (CDI), which can provide high lateral resolution and wide field of view. The theoretical resolution of ptychography is dose-limited, therefore making ptychography…

Biological Physics · Physics 2025-01-09 Huixiang Lin , Fucai Zhang

Ptychographic imaging at synchrotron and XFEL sources requires dense overlapping scans, limiting throughput and increasing dose. Extending coherent diffractive imaging to overlap-free operation on extended samples remains an open problem.…

Optics · Physics 2026-05-01 Oliver Hoidn , Albert Vong , Aashwin Mishra , Steven Henke , Matthew Seaberg

Dual-energy computed tomography (DECT) is of great significance for clinical practice due to its huge potential to provide material-specific information. However, DECT scanners are usually more expensive than standard single-energy CT…

Medical Physics · Physics 2020-06-02 Tianling Lyu , Zhan Wu , Yikun Zhang , Yang Chen , Lei Xing , Wei Zhao

In recent years, particular physical phenomena enabled by non-Hermitian metamaterial systems have attracted significant research interests. In this paper, a non-Hermitian three-dimensional metamaterial near the exceptional point (EP) is…

Applied Physics · Physics 2024-01-24 Yanjie Wu , Ding Zhang , Qiuyu Li , Hai Lin , Xintong Shi , Jie Xiong , Haoquan Hu , Jing Tian , Bian Wu , Y. Liu

Electron tomography, as an important 3D imaging method, offers a powerful method to probe the 3D structure of materials from the nano- to the atomic-scale. However, as a grant challenge, radiation intolerance of the nanoscale samples and…

Materials Science · Physics 2020-03-30 Chunyang Wang , Guanglei Ding , Yitong Liu , Huolin L. Xin

Scanning Transmission Electron Microscopy (STEM) coupled with Electron Energy Loss Spectroscopy (EELS) presents a powerful platform for detailed material characterization via rich imaging and spectroscopic data. Modern electron microscopes…

Instrumentation and Detectors · Physics 2024-06-18 Utkarsh Pratiush , Austin Houston , Sergei V Kalinin , Gerd Duscher

The Scanning electron microscope (SEM) and Electron-Dispersive Spectroscope (EDS) are two highly effective instruments in the field of nanoscience and nanotechnology. The quality of these instruments is determined by various factors, with…

Applied Physics · Physics 2023-10-24 Hamidreza Moradi , Fatemeh Mehradnia

Accurately recovering images from phaseless measurements is a challenging and long-standing problem. In this work, we present "deepECpr," which combines expectation-consistent (EC) approximation with deep denoising networks to surpass…

Computer Vision and Pattern Recognition · Computer Science 2024-11-27 Saurav K. Shastri , Philip Schniter

A new method has been developed for the correction of the distortions and/or enhanced phase differentiation in Electron Backscatter Diffraction (EBSD) data. Using a multi-modal data approach, the method uses segmented images of the phase of…

Data Analysis, Statistics and Probability · Physics 2019-03-11 Marie-Agathe Charpagne , Florian Strub , Tresa M. Pollock

A suite of acquisition applications related to the 4D-STEM technique is presented as a software package written within the Digital Micrograph environment, which is a widely used software platform in worldwide electron microscopy…

With the development of high-speed electron detectors, four-dimensional scanning transmission electron microscopy (4D-STEM) has emerged as a powerful tool for characterizing microstructures in material science and life science. However, the…

Instrumentation and Detectors · Physics 2023-06-16 Yiming Hu , Si Gao , Xiaopeng Wu , Xudong Pei , Futao Huang , Wei Mao , Weiyang Zhang , Aidan Horne , Zhengbin Gu , Peng Wang